Extracorporeal membrane oxygenation in acute respiratory distress syndrome due to influenza A (H1N1)pdm09 pneumonia. A single-center experience during the 2013-2014 season

Abstract

ObjectiveThis report aimed to describe the outcomes of the patients with severe H1N1 associated acute respiratory distress syndrome who were treated with extracorporeal membrane oxygenation therapy.MethodsThis retrospective review analyzed a single-center cohort of adult patients with H1N1-related acute respiratory distress syndrome who were managed with veno-venous extracorporeal membrane oxygenation during the winter of 2013/2014.ResultsA total of 10 patients received veno-venous extracorporeal membrane oxygenation for H1N1 influenza between January 2013 and March 2014. Seven patients were transferred to our center for extracorporeal membrane oxygenation consideration (all within 72 hours of initiating mechanical ventilation). The median patient age was forty years, and 30% were female. The median arterial oxygen partial pressure to fraction of inspired oxygen ratio was 62.5, and the median RESP score was 6. Three patients received inhaled nitric oxide, and four patients were proned as rescue therapy before extracorporeal membrane oxygenation was initiated. The median duration of mechanical ventilation was twenty-two days (range, 14 - 32). The median length of stay in the intensive care unit was twenty-seven days (range, 14 - 39). The median hospital length of stay was 29.1 days (range, 16.0 - 46.9). Minor bleeding complications occurred in 6 of 10 patients. Eight of the ten patients survived to hospital discharge.ConclusionThe survivors were relatively young and discharged with good functional status (i.e., enhancing quality-adjusted life-years-saved). Our experience shows that even a relatively new extracorporeal membrane oxygenation program can play an important role in that capacity and provide excellent outcomes for the sickest patients.

Cross-sectional study for the clinical application of extracorporeal membrane oxygenation in Mainland China, 2018

“…As treatment has become more sophisticated, centers have gained much more experience. Our results were consistent with those of several large randomized controlled studies conducted in ECMO centers, all showing lower mortality rates [ 2 , 16 , 20 ]. More stringent indications.…”

Influenza Species and Subtypes Circulation among Hospitalized Patients in Laleh Hospital during Two Influenza Seasonal (2016-2017 and 2017-2018) Using a Multiplex Real Time-Polymerase Chain Reaction

“…[10][11][12][13] Contrary to our results that showed subtype fluA H1N1 has least common prevalence, previous studies performed in Iran including prevalence of 10.6% to 17.5%. [14][15][16][17] The pattern of flu subtypes was different in two years period. Flu A was the dominant species in the 2016-2017 season, On the other hand, flu B was the major type in the 2017-1018 seasons.…”

Extracorporeal Membrane Oxygenation Support for Influenza A: Retrospective Review of the Extracorporeal Life Support Organization Registry Comparing H1N1 With Other Subtypes

“…ECMO support for ARDS continued to evolve after the H1N1 pandemic. A single-center study reported up to 80% survival for H1N1 patients supported on ECMO during 2013–2014 ( 39 ). Studies from Japan and Korea demonstrated improved outcomes during a resurgence of H1N1 in 2016 when compared with the 2009 pandemic, which likely reflects improvements in their patient selection and management and improvements in equipment ( 40 , 41 ).…”