A Sensitive Voltammetric Determination of Anti-Parkinson Drug Pramipexole Using Titanium Dioxide Nanoparticles Modified Carbon Paste Electrode

Abstract

In this study, a facile sensor based on TiO 2 nanoparticles modified carbon paste electrode was developed for voltammetric determination of pramipexole in pharmaceutical formulations and biological samples. Surface of the fabricated electrode have been characterized using field emission scanning electron microscopy. Under the optimized experimental conditions, the modified electrode was exhibited excellent electrocatalytic activities and a sensitive oxidation peak at 0.9 V in the phosphate solution of pH 5.0 for electrooxidation of pramipexole. The plot of pH vs. E p generated a slope of 62.5 mV per pH in the pH range of 3.0-13.0 indicating the contribution of an equal number of electrons and protons in the electrode process. A differential pulse voltammetry method was developed in the concentration range of 0.46-100 µmol L −1 with a limit of detection of 0.14 µmol L −1. The proposed method is simple, rapid, and inexpensive and also showed good selectivity and sensitivity toward pramipexole.

Electrocatalytic Activity of Asymmetrical Cobalt Phthalocyanines in the Presence of N Doped Graphene Quantum Dots: The Push‐pull Effects of Substituents

“…The linearity observed upon plotting the square root of the scan rate against the current (Figure C) suggested that the processes happening between the analyte and the electrode are largely diffusion controlled however, from a plot of the log I p vs log ν, it was established that this is not the case for all the probes (Figure D). Theoretically, a gradient of 0.5 or 1.0 from a plot of the log I p vs log ν corresponds with either diffusion or adsorption controlled processes, respectively (Figure D) . In all the probes studied, all but two were diffusion controlled.…”

Uncured Polydimethylsiloxane as Binder Agent for Carbon Paste Electrodes: Application to the Quantification of Propranolol

“…A chemically modified CPE is obtained by the simple addition of the chemical modifier to the mixture between graphite powder and the binder agent. Several chemical modifiers have been used such as ion exchange materials, 6,7 silica, and organofunctionalized silicas, [8][9][10][11] metallic nanoparticles, 12,13 oxides 14 and complexes, 15,16 carbon nanotubes, 17 etc. These materials have allowed the preparation of CPEs with superior analytical performance extending their application to trace analysis of different kinds of analytes, such as metal ions, 18,19 drugs, 20,21 organic pollutants, 22 and biologically important compounds.…”

Creating the Ideal Push‐Pull System for Electrocatalysis: A Comparative Study on Symmetrical and Asymmetrical Cardanol‐based Cobalt Phthalocyanines

“…The plot of log I p vs log ν (GCE‐ 3 as an example in Figure 7B ) revealed that the processes happening between the analyte and the modified electrodes are diffusion controlled with all the plots registering a slope of 0.5. In the case of adsorption‐based processes, a slope of 1 or close to 1 would be observed [28–30].…”