New Epimeric Spirostanol and Furostanol-Type Steroidal Saponins from<i>Cestrum laevigatum</i>L.

Ribeiro, Paulo Riceli Vasconcelos; Braz-Filho, Raimundo; Araújo, Ana Jérsia; Costa-Lotufo, Letı́cia V.; Souza, Luciana G. S.; Junior, Helio Vitoriano Nobre; Silva, Cecília Rocha da; Neto, João Batista de Andrade; Silveira, Edilberto R.; Lima, Mary Anne Sousa

doi:10.5935/0103-5053.20160109

Cited by 2 publications

(1 citation statement)

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“…Plants in the genus Cestrum (Solanaceae) are native to warm subtropical and tropical areas of America, and are now cultivated all over the world for ornamental purposes [ 1 ]. Cestrum species are rich sources of steroidal glycosides, and structurally diverse steroidal glycosides have been isolated from C. laevigatum [ 2 , 3 ], C. schlechtendahlii [ 4 ], C. ruizteranianum [ 5 ], C. parqui [ 6 , 7 , 8 ], C. diurnum [ 9 , 10 ], C. sendtenerianum [ 11 , 12 ], and C. nocturnum [ 13 , 14 , 15 ]. C. newellii is reputed to be a poisonous plant.…”

Section: Introductionmentioning

confidence: 99%

A Total of Eight Novel Steroidal Glycosides Based on Spirostan, Furostan, Pseudofurostan, and Cholestane from the Leaves of Cestrum newellii

2020

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Previously, various steroidal glycosides were reported from plants of Cestrum species. However, phytochemical investigation has not been conducted on Cestrum newellii. A systematic phytochemical investigation of the leaves of C. newellii resulted in the isolation of eight novel steroidal glycosides (1–8), which were classified into three spirostanol glycosides (1–3), two furostanol glycosides (4 and 5), two pseudofurostanol glycosides (6 and 7), and one cholestane glycoside (8). In addition, three known cholestane glycosides (9–11) were isolated and identified. The structures of the new compounds were determined based on spectroscopic data and chemical transformations. Compounds 1 and 2 are spirostanol glycosides having hydroxy groups at C-2, C-3, C-12, and C-24 of the aglycone moiety. Although C. newellii is known to be a poisonous plant, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay exhibited that none of the isolated compounds were cytotoxic to HL-60 human promyelocytic leukemia cells.

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Section: Introductionmentioning

confidence: 99%

A Total of Eight Novel Steroidal Glycosides Based on Spirostan, Furostan, Pseudofurostan, and Cholestane from the Leaves of Cestrum newellii

2020

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In vitro evidence of the antitumor capacity of Solanaceae and Cucurbitaceae in colon cancer: A systematic review

Mesas

Fuel

Martínez

et al. 2021

Critical Reviews in Food Science and Nutrition

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New Epimeric Spirostanol and Furostanol-Type Steroidal Saponins fromCestrum laevigatumL.

Abstract: Four new epimeric spirostanol and furostanol-type steroidal saponins, (25R,S)-5α-spirostan-

Cited by 2 publications

References 12 publications

A Total of Eight Novel Steroidal Glycosides Based on Spirostan, Furostan, Pseudofurostan, and Cholestane from the Leaves of Cestrum newellii

A Total of Eight Novel Steroidal Glycosides Based on Spirostan, Furostan, Pseudofurostan, and Cholestane from the Leaves of Cestrum newellii

In vitro evidence of the antitumor capacity of Solanaceae and Cucurbitaceae in colon cancer: A systematic review

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