Natural Product-Derived Drugs Based on β-Adrenergic Agents and Nucleosides

Abstract

This relatively short review demonstrates the very important role of the structures of the natural products adrenaline and relatives, in the design and subsequent approval of β-agonists and antagonists, and of modified nucleosides as anticancer, and in particular, antiviral agents against herpes (HSV), human immunodeficiency virus (HIV) and hepatitis C virus (HCV) that would not have been synthesized in the absence of knowledge of bioactive arabinose nucleosides.

Exploration of the expeditious potential of Pseudomonas fluorescens lipase in the kinetic resolution of racemic intermediates and its validation through molecular docking

“…30 It has been well established that the desirable therapeutic activities of β-aryloxyalcohols reside mainly in the (S)-enantiomers. 27,42,43 The chemical synthesis of enantiopure β-aryloxyalcohols was performed by the reaction of substituted phenols with chiral epichlorhydrin or glycidol, to give epoxide intermediates 28,46 followed by the ring opening of these epoxides. 3,7 However, the use of chiral reagents makes the process more cost intensive.…”

“…β‐Aryloxyalcohols are key intermediates in the synthesis of many important drugs . It has been well established that the desirable therapeutic activities of β‐aryloxyalcohols reside mainly in the ( S )‐enantiomers . The chemical synthesis of enantiopure β‐aryloxyalcohols was performed by the reaction of substituted phenols with chiral epichlorhydrin or glycidol, to give epoxide intermediates followed by the ring opening of these epoxides .…”