Appel Reaction of Carboxylic Acids with Tribromoisocyanuric Acid/Triphenylphosphine: a Mild and Acid-Free Preparation of Esters and Amides

Abstract

A facile and efficient method for esterification and amidation of carboxylic acids under neutral conditions has been developed. Esters and amides can be prepared by reacting a carboxylic acid (1 mmol) with tribromoisocyanuric acid (0.37 mmol) and triphenylphosphine (1 mmol) in dichloromethane at room temperature, followed by addition of an alcohol or an amine, respectively.

Antibacterial Activity of Benzyl Benzoate and Crotepoxide from <i>Kaempferia rotunda</i> L. Rhizome

“…Benzyl benzoate ( (Table 1) was the newest data from published data [17], where previous data was operating at 300 ( 1 H) and 75 ( 13 C) Mhz.…”