Rhenium(I) Polypyridine Complexes as Luminescence-Based Sensors for the BSA Protein

Frin, Karina Passalacqua Morelli; Nascimento, Verônica M.

doi:10.5935/0103-5053.20150268

Cited by 3 publications

(2 citation statements)

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“…25,32,33,40 The emission maxima ranged from 600 to 635 nm, as shown in Figure S18, and are bathochromically shifted for Re-pyr, Re-ind, and Re-cbz in comparison to Re-phen as a result of a more efficient stabilization of the 3 MLCT Re→NN excited state by the presence of additional aromatic rings. 28,41,42 The PL quantum yields (Φ PL ) and lifetimes (τ PL ) increased in the order Re-cbz < Reind < Re-pyr < Re-phen, as shown in Table 2, following the decrease in the number of aromatic rings of the substituent in the NN ligand. The presence of the N-heterocyclic substituents favored the nonradiative decay that competes with the radiative deactivation of the excited state.…”

Section: Spectroscopic Electrochemical and Photophysicalmentioning

confidence: 99%

Visible-Light-Driven Photocatalytic CO₂ Reduction by Re(I) Photocatalysts with N-Heterocyclic Substituents

et al. 2022

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The properties and reactivity of metal complex photocatalysts for solar-to-fuel conversion can be conveniently controlled by the molecular design of their ligands. In this work, rhenium(I) tricarbonyl polypyridyl compounds, fac-[Re(NN)(CO) 3 Cl], where NN is a 1,10-phenanthroline ligand having pyrrole (Re-pyr), indole (Re-ind), or carbazole (Re-cbz) groups attached to its 4 and 7 positions, were investigated as photocatalysts for reducing CO 2 to CO. These complexes can harvest light in the visible region and displayed an exceptionally high photocatalytic performance, with an up to 10-fold increase in the TON CO values compared to the unsubstituted Re-phen parental complex. Re-pyr was the best performing photocatalyst in this series, with a TON CO of 125 after 24 h and Φ CO = 0.22. The TON CO of Re-pyr, Re-ind, and Re-cbz surpassed even the most efficient Lehn-type photocatalysts reported to date to promote the photoreduction of CO 2 using triethanolamine as the sacrificial electron donor, without a second molecule working as a light absorber. The excellent photocatalytic performance of this series was intimately related to the presence of N-heterocyclic substituents, which enhanced the visible-light absorption properties of the compounds, favored the kinetics and thermodynamics of each individual step of the photocatalysis, inhibited deactivation of the photocatalysts by dimerization, stabilized reduced intermediates, and unlocked an alternative CO 2 photoreduction pathway that proceeds predominantly through a two-electron reduced species [Re(NN)(CO) 3 ] − .

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Section: Spectroscopic Electrochemical and Photophysicalmentioning

confidence: 99%

Visible-Light-Driven Photocatalytic CO₂ Reduction by Re(I) Photocatalysts with N-Heterocyclic Substituents

et al. 2022

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“…The association and/or interaction of Re(I) compound with the amino acid residues of the polypeptide chain of BSA induced a conformational change of the secondary structure of the protein with a decrease of its -helicity [90].…”

Section: Interactions Of Re-complexes With Proteinsmentioning

confidence: 99%

Design of Rhenium Compounds in Targeted Anticancer Therapeutics

Collery¹,

Desmaële

Veena

2019

CPD

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Background: Many rhenium (Re) complexes with potential anticancer properties have been synthesized in the recent years with the aim to overcome the clinical limitations of platinum agents. Re(I) tricarbonyl complexes are the most common but Re compounds with higher oxidation states have also been investigated, as well as hetero-metallic complexes and Re-loaded self-assembling devices. Many of these compounds display promising cytotoxic and phototoxic properties against malignant cells but all Re compounds are still at the stage of preclinical studies. Methods: The present review focused on the rhenium based cancer drugs that were in preclinical and clinical trials were examined critically. The detailed targeted interactions and experimental evidences of Re compounds reported by the patentable and non-patentable research findings used to write this review. Results: In the present review, we described the most recent and promising rhenium compounds focusing on their potential mechanism of action including, phototoxicity, DNA binding, mitochondrial effects, oxidative stress regulation or enzyme inhibition. Many ligands have been described that modulating the lipophilicity, the luminescent properties, the cellular uptake, the biodistribution, and the cytotoxicity, the pharmacological and toxicological profile. Conclusion: Re-based anticancer drugs can also be used in targeted therapies by coupling to a variety of biologically relevant targeting molecules. On the other hand, combination with conventional cytotoxic molecules, such as doxorubicin, allowed to take into profit the targeting properties of Re for example toward mitochondria. Through the example of the diseleno-Re complex, we showed that the main target could be the oxidative status, with a down-stream regulation of signaling pathways, and further on selective cell death of cancer cells versus normal cells.

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The impact of biomolecule interactions on the cytotoxic effects of rhenium(I) tricarbonyl complexes

de Lavor,

Teixeira,

de Matos

et al. 2024

Journal of Inorganic Biochemistry

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Rhenium(I) Polypyridine Complexes as Luminescence-Based Sensors for the BSA Protein

Cited by 3 publications

References 1 publication

Visible-Light-Driven Photocatalytic CO₂ Reduction by Re(I) Photocatalysts with N-Heterocyclic Substituents

Visible-Light-Driven Photocatalytic CO₂ Reduction by Re(I) Photocatalysts with N-Heterocyclic Substituents

Design of Rhenium Compounds in Targeted Anticancer Therapeutics

The impact of biomolecule interactions on the cytotoxic effects of rhenium(I) tricarbonyl complexes

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Rhenium(I) Polypyridine Complexes as Luminescence-Based Sensors for the BSA Protein

Cited by 3 publications

References 1 publication

Visible-Light-Driven Photocatalytic CO2 Reduction by Re(I) Photocatalysts with N-Heterocyclic Substituents

Visible-Light-Driven Photocatalytic CO2 Reduction by Re(I) Photocatalysts with N-Heterocyclic Substituents

Design of Rhenium Compounds in Targeted Anticancer Therapeutics

The impact of biomolecule interactions on the cytotoxic effects of rhenium(I) tricarbonyl complexes

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Product

Resources

About

Visible-Light-Driven Photocatalytic CO₂ Reduction by Re(I) Photocatalysts with N-Heterocyclic Substituents

Visible-Light-Driven Photocatalytic CO₂ Reduction by Re(I) Photocatalysts with N-Heterocyclic Substituents