Piperamides from<i>Piper ottonoides</i>by NMR and GC-MS Based Mixture Analysis

Wolff, Thiago; Santos, Priscila F. P.; Valente, Lígia M. M.; Magalhães, Alviclér; Tinoco, Luzineide W.; Pereira, Ricardo; Guimarães, Elsie Franklin

doi:10.5935/0103-5053.20150226

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“…The neutral losses are in accordance with the presence of a piperadine (P108), isobutylamine (P105) and pyrrolidine (P93) moiety. By matching the MS/MS spectra with those reported in the literature and databases, these compounds could be putatively identified as piperdardine (P108), chingchengenamide A (P105) and nigrinodine (P93), respectively [ 22 , 56 , 94 ]. Generally, the number of double bonds in all compounds could be calculated by the degree of unsaturation and their positions were estimated by the fragmentation losses and the literature data.…”

Section: Resultsmentioning

confidence: 99%

Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling

Ware,

Franke,

Frolov

et al. 2024

Nat. Prod. Bioprospect.

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Piper sarmentosum Roxb. (Piperaceae) is a traditional medicinal and food plant widely distributed in the tropical and subtropical regions of Asia, offering both health and culinary benefits. In this study the secondary metabolites in different organs of P. sarmentosum were identified and their relative abundances were characterized. The metabolic profiles of leaves, roots, stems and fruits were comprehensively investigated by liquid chromatography high-resolution mass spectrometry (LC-HR-MS) and the data subsequently analyzed using multivariate statistical methods. Manual interpretation of the tandem mass spectrometric (MS/MS) fragmentation patterns revealed the presence of 154 tentatively identified metabolites, mostly represented by alkaloids and flavonoids. Principle component analysis and hierarchical clustering indicated the predominant occurrence of flavonoids, lignans and phenyl propanoids in leaves, aporphines in stems, piperamides in fruits and lignan-amides in roots. Overall, this study provides extensive data on the metabolite composition of P. sarmentosum, supplying useful information for bioactive compounds discovery and patterns of their preferential biosynthesis or storage in specific organs. This can be used to optimize production and harvesting as well as to maximize the plant’s economic value as herbal medicine or in food applications. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%