Synthesis of Alkylseleno-Carbohydrates and Evaluation of their Antioxidant Properties

Ultrasound and Oxone® promoting regioselective selenofunctionalization of chromone

“…In this test with ultrasound, fortunately a decrease in reaction time occurred from 24 h to 0.8 h giving the compound 3a in 86% yield (Table 1, entry 2). Encouraged by this result, a comparative study was carried out to check the influence of different stoichiometric amounts of diselenides 2a and Oxone®, as well as the best reaction solvent for this synthesis (Table 1, entry [3][4][5][6][7][8][9][10][11][12]. In order to increase the reaction yield, a reaction was performed using excess reagent 2a, however no significant increase in reaction yield occurred (Table 1, entry 3).…”

“…4 Indeed, selenium is recognized as an essential micronutrient of particular interest because of its ability to participate in crucial redox reactions that are particularly implicated in antioxidant, 5 chemopreventive 6 or apoptotic activities. 7 In addition, the chemical modification of natural compounds is of utmost strategic importance, to those considering increasing or improving the biological activities already present in a natural way, for example, the selenium-containing citronellol derivatives causing the potentiation of the antioxidant activity of this natural compound, 8 the insertion of selenium into structures of sugars 9 and the selenofunctionalization of a flavonoid, chrysin, enhancing the antioxidant and anticancer activities. 10 Another class of compounds, which play an important role in the design and discovery of new pharmacologically active compounds, are heterocyclic compounds, among which are flavonoids.…”

Organic selenocompounds: are they the panacea for human illnesses?

“…, with biological activities have been synthesized in different laboratories. 125,179–208 Unfortunately, they have been rarely tested in models related to their recognized biological effects. For instance, in a recent elegant and rational study, 209 the neurochemical behavior of selenofluoxetine was compared with fluoxetine by quantifying the cerebral (hippocampal) serotonin levels in living mice.…”

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

“…(2015) reported synthesis of simple alkylseleno-carbohydrates with different sugar scaffolds. Screening of the selected compounds for antioxidant activity revealed that several of them express free radical scavenging activity and therefore can potentially prevent oxidative damage of proteins and lipids [242].…”