Butyrolactones from the Endophytic FungusAspergillus versicolorand their Anti-Tobacco Mosaic Virus Activity

Marine natural products

“…179 cultured in liquid media resulted in incorporation into versicolamide B and also into seven new metabolites 185-191, which were not produced under normal culture conditions. The same incorporation experiment on agar medium resulted in production of four additional new metabolites, [192][193][194][195]. All were produced as racemic mixtures.…”

Natural product diversity from the endophytic fungi of the genusAspergillus

“…Aspernolides C (106) and D (107) displayed moderate anti-tobacco mosaic virus (anti-TMV) activity with IC 50 values of 64.2 and 88.6 mM, respectively. 45 The xanthones, named huperxanthones A-C (108-110), along with 1,7-dihydroxy-8(methoxycarbonyl)xanthone-3carboxylic acid (111), b-diversonolic acid methyl ester (112), 4hydroxyvertixanthone (113) and sydowinin B (114) were obtained from the endophytic fungus A. versicolor isolated from the stems of the medicinal plant Huperzia serrata (Fig. 15).…”

γ-Butyrolactones from Aspergillus Species: Structures, Biosynthesis, and Biological Activities

“…However, 3, 1, 16, and 74 showed modest anti-TMV activity with inhibition rates of 21.8, 20.8, 24.6, and 15.4 %, respectively compared with ningnanmycin (30.6 inhibition %) [44]. Zhou et al reported that 19 and 21 exhibited moderate anti-TMV activities with IC 50 values of 64.2 and 88.6 μM, respectively compared with ningnanmycin (IC 50 52.4 μM) using the half-leaf method [25]. Also, 5 and 39 showed high anti-TMV activities with inhibition rates of 35.4 and 46.4%, which were even more potent than ningnanmycin (30.8%) .…”

“…The nomenclature and chemical structures are listed based on the literature. During our search we found that some of the published compounds have the same nomenclatures but different chemical structures, such as aspernolide D [24][25], aspernolide C [14,25], and aspulvinone H [26][27][28]. Also, some compounds have the same chemical structures and molecular formulae, but have different nomenclature e.g.…”

“…A. terreus isolated from the internal tissue of the healthy roots of Carthamus lanatus (Asteraceae) C 26 H 30 O 9[47] Aspernolide H(25) Aspergillus iizukae isolated from the intestines of cricket species, Gryllus testaceu, which was collected from a suburb of Nanjing, Jiangsu Provinces.C25 H 8 O 9 [48] Aspernolide I (26) Aspergillus iizukae, isolated from the intestines of cricket species, Gryllus testaceu, which was collected from a suburb of Nanjing, Jiangsu Provinces. C 25 H 8 O 9 [48] Aspernolide J (27) Aspergillus iizukae, isolated from the intestines of cricket species, Gryllus testaceu, which was collected from a suburb of Nanjing, Jiangsu Provinces.…”