The Correlation Between Electronic Structure and Antimalarial Activity of Tetrahydropyridines

Electronic descriptors for the antimalarial activity of sulfonamides

“…Different statistical methods were employed to evaluate possible structure-activity correlations: simple and multiple linear regressions (SLR and MLR), principal component analysis (PCA), and linear discriminant analysis (LDA). In particular, PCA and LDA have shown to be interesting multivariate methods for pattern recognition and classification, having been successfully employed in QSAR studies of a variety of compounds (Autreto and Lavarda, 2008;Batagin-Neto and Lavarda, 2014;Naranjo-Montoya et al, 2014).…”

Ultrasound-assisted aqua-mediated synthesis of multi-substituted tetrahydropyridine-3-carboxylates using N-carboxymethyl-3-pyridinium hydrogensulfate ([N-CH2CO2H-3-pic]+HSO4−) as a new efficient ionic liquid catalyst

“…Tetrahydropyridine (THP) moiety exists in various alkaloids and natural products [5]. Tetrahydropyridine existence in heterocycles cause to different pharmacological and biological activities such as antimicrobial activity against Escherichia coli [6], antimalarial [7], anti-oxidant (which made them as potent radical scavengers) [8], anti-fungicidal and insecticidal [9], anti-tumor [10], and neuroprotective (Parkinson's disease) [11]. Some compounds hold THP scaffolds also used as corrosion inhibitors for mild steel [12], Recently a wide range of functionalized tetrahydropyridine-3-carboxylates has been synthesized via the reaction of various aldehydes, amines, and β-keto esters utilizing various catalysts under different conditions such as: bromodimethylsulfonium bromide (BDMS) in acetonitrile at room temperature [13], FeCl 3 /SiO 2 NPs in refluxing methanol [14], Bi(III) immobilized on triazine magnetized dendrimer (Fe 3 O 4 @TDSN-Bi(III)) in ethanol at room temperature [15], nano-Al 2 O 3 /BF 3 /Fe 3 O 4 at 80 °C [16], CAN in Supplementary Information The online version contains supplementary material available at https:// doi.…”

Diastereoselective Synthesis of Symmetrical and Unsymmetrical Tetrahydropyridines Catalyzed by Bi(III) Immobilized on Triazine Dendrimer Stabilized Magnetic Nanoparticles

“…1,2,5,6-Tetrahydropyridine (THP), piperidine, and their derivatives are attractive targets as components of natural products and other biologically active compounds, including those with anticonvulsant, antibacterial, anticancer, antihypertensive, and antimalarial properties. Methods for the synthesis of THP derivatives are therefore of significant interest.…”