Leishmaniasis and Chagas Disease Chemotherapy: a Critical Review

Silva, Alexandre de Almeida e; Thiemann, Otávio Henrique; Aníbal, Fernanda F.

doi:10.5935/0103-5053.20140229

Cited by 15 publications

(11 citation statements)

References 2 publications

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“…The parasitic diseases malaria, leishmaniasis, echinococcus, Chagas disease (American trypanosomiasis), onchocerciasis (“river blindness”), dracunculiasis (“guinea worm disease”), trypanosomiasis (“sleeping sickness”), schistosomiasis, lymphatic filariasis (elephantiasis), and others in tropical and sub-tropical regions put billions of people at risk and account for millions of illnesses and deaths annually [ 99 , 100 , 101 , 102 , 103 , 104 ]. The need for new drugs to combat these parasite vectors is paramount, and a number of newly isolated halogenated marine natural products display antiparasitic activity.…”

Section: Antiparasitic Activitymentioning

confidence: 99%

Biological Activity of Recently Discovered Halogenated Marine Natural Products

2015

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Section: Antiparasitic Activitymentioning

confidence: 99%

Biological Activity of Recently Discovered Halogenated Marine Natural Products

2015

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“…and chemotherapy remains the only means of treatment for Chagas disease and leishmaniasis. Meanwhile, the drugs available for treatment are few and their efficacy are limited, mainly due to the development of resistance and the lack of host specificity (Silva-Jardim, Thiemann, & Anibal, 2014). Many plants harbor trypanosomatids, which primarily reside in the xylem, phloem tubes (Dollet, 2001), fruits and/or seeds (Jankevicius et al, 1989;Jankevicius et al, 1993) of infected plants.…”

Section: Introductionmentioning

confidence: 99%

<b>Behavior of α-tomatine and tomatidine against several genera of trypanosomatids from insects and plants and <i>Trypanosoma cruzi

Evangelista

Kavati

Jankevicius

et al. 2018

Acta Sci. Biol. Sci.

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Glycoalkaloids are important secondary metabolites accumulated by plants as protection against pathogens. One of them, α-tomatine, is found in high concentrations in green tomato fruits, while in the ripe fruits, its aglycone form, tomatidine, does not present a protective effect, and it is usual to find parasites of tomatoes like Phytomonas serpens in these ripe fruits. To investigate the sensitivity of trypanosomatids to the action of α-tomatine, we used logarithmic growth phase culture of 20 trypanosomatids from insects and plants and Trypanosoma cruzi. The lethal dose 50% (LD50) was determined by mixing 10 7 cells of the different isolates with α-tomatine at concentrations ranging from 10-3 to 10-8 M for 30 min at room temperature. The same tests performed with the tomatidine as a control showed no detectable toxicity against the same trypanosomatid cultures. The tests involved determination of the percentage (%) survival of the protozoan cultures in a Neubauer chamber using optical microscopy. The LD50 values varied from 10-4 to 10-6 M α-tomatine. Slight differences were detected among the LD50 values of the analyzed samples, and none of them showed evidence of resistance to the action of tomatinase, as shown by some pathogenic fungi.

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“…Development and production of vaccine is experimentally cost effective, while the advancements in molecular immunology and the identification of dominant immune epitopes have been making fundamental changes in these experimental methods (Silva-Jardim et al 2014 ; Sundar et al 2019 ; Oli et al 2020 ). Advanced tools based on bioinformatics and immunoinformatic methods are used to develop and design a vaccine that reduces the negative aspects of empirical methods, including preventing predictable ethical aspects of laboratory works and expensive experimental studies and being time consuming.…”

Section: Discussionmentioning

confidence: 99%