Phenolic Compounds from<i>Clinopodium tomentosum</i>(Kunth) Govaerts (Lamiaceae)

Saltos, Mariela Beatriz Vera; Naranjo, Blanca; Malafronte, Nicola; Braca, Alessandra

doi:10.5935/0103-5053.20140181

Cited by 7 publications

(9 citation statements)

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“…Chemistry: Compounds 4, 10, [34] 12, [35] 19, [36] 22, [37] 24, [38] and 25 [39] were isolated from various plant extracts, as previously reported. Quercetin 8 was obtained from Sigma-Aldrich.…”

Section: Methodsmentioning

confidence: 99%

Targeting Different Transthyretin Binding Sites with Unusual Natural Compounds

et al. 2016

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Misfolding and aggregation of the transthyretin (TTR) protein leads to certain forms of amyloidosis. Some nutraceuticals, such as flavonoids and natural polyphenols, have recently been investigated as modulators of the self-assembly process of TTR, but they generally suffer from limited bioavailability. To discover innovative and more bioavailable natural compounds able to inhibit TTR amyloid formation, a docking study was performed using the crystallographic structure of TTR. This computational strategy was projected as an adhoc inspection of the possible relationship between binding site location and modulation of the assembly process; interactions with the as-yet-unexplored epigallocatechin gallate (EGCG) sites and with the thyroxine (T4) pocket were simultaneously analyzed. All the compounds studied seem to prefer the traditional T4 binding site, but some interesting results emerged from the screening of an in-house database, used for validating the computational protocol, and of the Herbal Ingredients Targets (HIT) catalogue available on the ZINC database

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Section: Methodsmentioning

confidence: 99%

Targeting Different Transthyretin Binding Sites with Unusual Natural Compounds

et al. 2016

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“…Clinopodium tomentosum is known by the vernacular names of "tiglán", "santa maría", and "pumín", and is widely distributed in Ecuador. Several traditional uses have been documented, generally using infusions of its flowers, leaves, and stems (Vera Saltos et al 2014, Vera Saltos 2015, Moncayo Miño 2020. Clinopodium axillare (Rusby) Harley, an endemic species from the highlands of Bolivia, has several traditional medicinal uses, which have been verified by studies of the composition of their essential oils and properties (Vila et al 1996, Senatore et al 1998, López 2019.…”

Section: Discussionmentioning

confidence: 99%

New leaf-mining Nepticulidae (Lepidoptera): potential pests of aromatic Lamiaceae plants from equatorial Andes

Stonis

Diškus

Fernández-Alonso

et al. 2021

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Members of the Lamiaceae, or mint family, are used worldwide for medicinal, culinary and/or magical-religious purposes, as well as in pesticides and as ornamental plants. Very little is known about nepticulids, or pygmy moths, as leaf miners of Lamiaceae, but they may be an important component of South American diversity and potential pests of economically-important species of the mint family. In this paper, four new species of leaf-mining Nepticulidae are described from the equatorial Andes of Ecuador: S. mentholica Diškus & Stonis, sp. nov., Stigmella aromatica Diškus & Stonis, sp. nov., S. odora Diškus & Stonis, sp. nov., feeding on Minthostachys mollis (Benth.) Griseb., and S. tomentosella Diškus & Stonis, sp. nov., feeding on Clinopodium tomentosum (Kunth) Govaerts. It is hypothesized that host-plant distribution ranges can provide clues to potential distribution ranges of these newly discovered, trophically specialized leaf miners. The leaf mines, adults, and the genitalia of the new species are illustrated with photographs.

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“…Among the Ecuadorian clinopidum species, Clinopidium nubigenum stands out for its antimicrobial respiratory activity [ 27 ]; and Clinopodium tomentosum is anti-inflammatory [ 28 ]. Clinopodium brownei , an aromatic, herbaceous species, is found in the southeastern United States, Central America, the Caribbean, and South America; in Ecuador, it is found in tropical and subtropical areas of several provinces [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antimicrobial and Antioxidant Bioautography Activity of Essential Oil from Leaves of Amazon Plant Clinopodium brownei (Sw.)

et al. 2023

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The Amazonian region of Ecuador has an extremely rich vegetal biodiversity, and its inhabitants have proven to have a millennial ancestral knowledge of the therapeutic and medicinal use of these resources. This work aimed to evaluate the chemical composition and biological activity of the essential oil obtained from the medicinal plant Clinopodium brownei (Sw.) Kuntze, which is widely spread in tropical and subtropical America. This species is traditionally used for treating respiratory and digestive diseases and is also known for its analgesic properties. Most of the molecules detected on a non-polar column were ethyl cinnamate 21.4%, pulegone 20.76%, methyl cinnamate 16.68%, caryophyllene 8.17%, β-selinene 7.92% and menthone 7.51%, while those detected on a polar column were: pulegone 29.90%, ethyl cinnamate 18.75%, methyl cinnamate 13.82%, caryophyllene 10.0% and menthone 8.04%. The antioxidant activity by the assays, DPPH (2.2-diphenyl-1-picrylhydrazyl) and ABTS (2.2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)), shows the following values of 50% inhibition of oxidation, IC50 DPPH 1.77 mg/mL, IC50 ABTS 0.06 mg/mL, which, compared to the essential oil of Thymus vulgaris (natural positive control), turn out to be less active. Bioautography indicates that the molecules responsible for the antioxidant activity are derived from cinnamic acid: ethyl cinnamate and methyl cinnamate, and caryophyllene. The antimicrobial activity on the nine microorganisms evaluated shows bacterial growth inhibitory concentrations ranging from 13.6 mg/mL for Staphylococcus epidermidis ATCC 14990 to 3.1 mg/mL for Candida albicans ATCC 10231; the results are lower than those of the positive control. Bioautography assigns antimicrobial activity to caryophyllene. The results indicate a very interesting activity of the essential oil and several of its molecules, validating the traditional use and the importance of this medicinal plant from Ecuador.

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Phenolic Compounds fromClinopodium tomentosum(Kunth) Govaerts (Lamiaceae)

Cited by 7 publications

References 0 publications

Targeting Different Transthyretin Binding Sites with Unusual Natural Compounds

Targeting Different Transthyretin Binding Sites with Unusual Natural Compounds

New leaf-mining Nepticulidae (Lepidoptera): potential pests of aromatic Lamiaceae plants from equatorial Andes

Chemical Composition, Antimicrobial and Antioxidant Bioautography Activity of Essential Oil from Leaves of Amazon Plant Clinopodium brownei (Sw.)

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