The Semisynthetic Landscape of Aphidicolin: Inspiration Towards Leishmanicidal Compounds

Santos, Gabriela Bianchi dos; Almeida, Marília Oliveira de; Cardoso, Iara Aimê; Manfrim, Viviane; Chagas, Fernanda O.; Toledo, Juliano Simões de; Pinzan, Camila C.; Araújo, Alexandre Suman de; Cruz, Ângela K.; Pupo, Mônica Tallarico; Emery, Flávio da Silva

doi:10.5935/0103-5053.20140162

Cited by 2 publications

(1 citation statement)

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“…Later, in 2019, Niu et al, carried out the chemical study of the marine strain B. fuckeliana MCCC 03A00494, isolated from deep-sea water in the Western Pacific Ocean, which produced 71 new ( 70 - 140 ) and eight known metabolites ( 141 - 148 ) ( Figure 19 and Figure 20 ) [ 85 ]. All compounds obtained were aphidicolins, tetracyclic diterpenes with a 6/6/5/6 ring system which are potential nuclear DNA replication inhibitors in eukaryotic cells and in some viruses and have, therefore, been thoroughly studied for the treatment of cancer [ 89 , 90 ]. Among the isolated compounds, 12 still need to have their stereochemistry fully defined.…”

Section: Botryotinia Fuckeliana (De Bary) Wetzel (The Teleom...mentioning

confidence: 99%

From Genes to Molecules, Secondary Metabolism in Botrytis cinerea: New Insights into Anamorphic and Teleomorphic Stages

Ripardo-Filho

Ruíz

Suárez

et al. 2023

Plants

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The ascomycete Botrytis cinerea Pers. Fr., classified within the family Sclerotiniaceae, is the agent that causes grey mould disease which infects at least 1400 plant species, including crops of economic importance such as grapes and strawberries. The life cycle of B. cinerea consists of two phases: asexual (anamorph, Botrytis cinerea Pers. Fr.) and sexual (teleomorph, Botryotinia fuckeliana (de Bary) Wetzel). During the XVI International Symposium dedicated to the Botrytis fungus, which was held in Bari in June 2013, the scientific community unanimously decided to assign the most widely used name of the asexual form, Botrytis, to this genus of fungi. However, in the literature, we continue to find articles referring to both morphic stages. In this review, we take stock of the genes and metabolites reported for both morphic forms of B. cinerea between January 2015 and October 2022.

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Section: Botryotinia Fuckeliana (De Bary) Wetzel (The Teleom...mentioning

confidence: 99%