Monitoring of Diclofenac with Biomimetic Sensor in Batch and FIA Systems

Wong, Ademar; Marestoni, Luiz Diego; Sotomayor, Marı́a Del Pilar Taboada

doi:10.5935/0103-5053.20140108

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…The electronic spectrum of Schiff base ligand shows two bands at 298 and 371 nm which can be attributed due to π→π⃰ , n→π⃰ , intraligand charge transfer transitions of benzene and non-bonding electrons present on the nitrogen atom of azomethine group. The Cu (II) is a d 9 ion and provides a good example for the John-Teller effect. The electronic spectrum of Cu (II) complex shows absorption bands at 343 and 670 nm due to 2 B1g 2 Eg , 2 B1g 2 A1g transitions.…”

Section: Electronic Spectra and Magnetic Susceptibilitymentioning

confidence: 99%

“…Since long-term usage of NSAIDs causes gastrointestinal problems, it has become important to synthesis novel drugs with lesser side effects. [5][6][7][8][9][10] Literature survey reveals that Schiff base metal complexes had shown promising anti-inflammatory activities. 11,12 Therefore, the current study was aimed at preparing, spectrally analyzing, and biologically evaluating a Schiff base ligand and its metal complexes.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, Antimicrobial and Anti-Inflammatory Studies of Some Novel Schiff Base Metal Complexes Derived From the Drug, Diclofenac

Shilpa¹,

Shivaprasad²,

Archana³

2021

RJC

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The synthesis of Schiff base transition metal complexes always appears to be fascinating because of the possibility of obtaining coordination compounds of unusual structure and stability. These compounds possess special attention in the field of pharmaceuticals because of their wide spectrum of biological applications. Schiff base complexes form versatile compounds which actively take part in metalloenzymes and also can act as biomimetic models because of their closeness to natural proteins and enzymes. Hence, the present paper mainly aims in the synthesis of Schiff base ligand by modifying the functional group of the drug, diclofenac and using that Schiff base ligand four novel metal complexes of Cu(II), Co(II), Ni(II), and Zn(II) were prepared. The nature of bonding and the stereochemistry of the metal complexes can be deduced from elemental analyses, molar conductance, magnetic susceptibility, IR, electronic, 1 H NMR and Mass. The analytical data reveals that the metal to ligand ratio is 1:2. Due to lower molar conductivity values, the metal complexes are considered nonelectrolytes. The spectral analysis data describes that all the metal complexes possess octahedral geometry. The drug diclofenac synthesized Schiff base ligand and novel metal complexes were subjected to antimicrobial as well as anti-inflammatory activities. The Schiff base ligand and metal complexes show promising biological activities.

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Section: Electronic Spectra and Magnetic Susceptibilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Antimicrobial and Anti-Inflammatory Studies of Some Novel Schiff Base Metal Complexes Derived From the Drug, Diclofenac

Shilpa¹,

Shivaprasad²,

Archana³

2021

RJC

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Voltammetric Behaviour of Drug Molecules as a Predictor of Metabolic Liabilities

et al. 2020

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Electron transfer plays a vital role in drug metabolism and underlying toxicity mechanisms. Currently, pharmaceutical research relies on pharmacokinetics (PK) and absorption, distribution, metabolism, elimination and toxicity (ADMET) measurements to understand and predict drug reactions in the body. Metabolic stability (and toxicity) prediction in the early phases of the drug discovery and development process is key in identifying a suitable lead compound for optimisation. Voltammetric methods have the potential to overcome the significant barrier of new drug failure rates, by giving insight into phase I metabolism events which can have a direct bearing on the stability and toxicity of the parent drug being dosed. Herein, we report for the first time a data-mining investigation into the voltammetric behaviour of reported drug molecules and their correlation with metabolic stability (indirectly measured via t½), as a potential predictor of drug stability/toxicity in vivo. We observed an inverse relationship between oxidation potential and drug stability. Furthermore, we selected and prepared short- (<10 min) and longer-circulation (>2 h) drug molecules to prospectively survey the relationship between oxidation potential and stability.

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Monitoring of Diclofenac with Biomimetic Sensor in Batch and FIA Systems

Cited by 2 publications

References 2 publications

Synthesis, Characterization, Antimicrobial and Anti-Inflammatory Studies of Some Novel Schiff Base Metal Complexes Derived From the Drug, Diclofenac

Synthesis, Characterization, Antimicrobial and Anti-Inflammatory Studies of Some Novel Schiff Base Metal Complexes Derived From the Drug, Diclofenac

Voltammetric Behaviour of Drug Molecules as a Predictor of Metabolic Liabilities

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