Efficient One Pot Synthesis of Xanthene-Triazole-Quinoline/Phenyl Conjugates and Evaluation of their Antimicrobial Activity

Synthesis, antimicrobial evaluation, and molecular docking studies of novel chromone based 1,2,3-triazoles

“…Recently, regioselectivity of the reaction was improved by Sharpless and Meldal by introducing Cu(I) catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) to afford 1,4-disubstituted 1,2,3-triazole [19,20]. The triazole nucleus is an important pharmacophore appearing extensively in various types of pharmaceutical agents and bioactive molecules, such as anti-HIV [21], antitubercular [22], anti-inflammatory, anticancer [23], antimicrobial [24], anticonvulsant [25], V. S. Dofe et al antimalarial [26], analgesic [27], antiviral [28], antidiabetic [29], antimycobacterial [30], and anticholinesterase [31]. The biological activity of these compounds is enhanced probably due to their high aromatic stabilisation, high dipole moment, and high bonding capacity.…”

Thiazolidine‐4‐one clubbed pyrazoles hybrids: Potent α‐amylase and α‐glucosidase inhibitors with NLO properties

“…Thiazolidine‐4‐one, a privileged pharmacophore, came into existence for its role as an antihyperglycemic agent and is a part of a number of antidiabetic drugs . Thiazolidin‐4‐one has been emerged as a very persuasive scaffold because of its clinical significance and widespread pharmacological activities associated with it . Similarly, another significant class of compound, named pyrazole has a broad range of biological activities such as anti‐inflammatory, antifungal, antioxidant, antitumor, antihypertensive, antibacterial, anticancer activity, and antidiabetic activities associated with it.…”

“…Persisting our interest in the design and development of biologically active heterocyclic compounds and novel inhibitor of α‐amylase we, herein, report the design and synthesis of a hybrid scaffold having thiazolidin‐4‐one and pyrazole in a single matrix. 1 H NMR and density functional theory (DFT) studies explored the isomerization in the synthesized compounds.…”

Choline chloride and itaconic acid-based deep eutectic solvent as an efficient and reusable medium for the preparation of 13-aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraones

“…Xanthene and their derivatives are an important class of heterocyclic compounds that exhibit broad spectra of pharmaceutical and biological properties, such as antimicrobial [1], antiproliferative [2], antibacterial [3], and antioxidant activity [4]. Xanthenes can also be used in the preparation of stable laser dyes [5], fluorescent sensor [6,7], and protein labelling fluorophores [8].…”