A New Flavonoid Derivative from Leaves of<i>Oxandra sessiliflora</i>R. E. Fries

Sousa, Elcilene Alves de; Silva, Armenio André de Carvalho Almeida da; Cavalheiro, Alberto José; Lago, João Henrique G.; Chaves, Mariana Helena

doi:10.5935/0103-5053.20140023

Cited by 6 publications

(5 citation statements)

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“…13 Compound 4 was reported in Oxandra sessiliflora (Annonaceae) and Acacia pennata Willd (Mimosaceae). 14,26 Compound 5, called manghaslin, was previously isolated from Glycine max (Fabaceae). 27 It was first found in Cerbera manghas (Apocynaceae).…”

Section: Resultsmentioning

confidence: 99%

Chemical composition and antioxidant activity of Astragalus monspessulanus L. growing in semiarid areas of Algeria

Bourezzane

Haba

Long

et al. 2018

JSCS

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This paper reports a phytochemical study of the aerial parts of Astragalus monspessulanus L. growing in Algeria. It deals with the isolation and structure elucidation of 13 known compounds. From the n-butanol extract, seven flavonoids 1-7, two saponins and one lignan were isolated. In addition, two phytosterols and one triterpenoid were isolated from the ethyl acetate extract. The structures of all the isolated products were determined by using 1D and 2D-NMR techniques, measurement of optical rotation, mass spectrometry ESI-MS and by comparison with literature data. Furthermore, the antioxidant activity of the n-butanol extract of the aerial parts of Astragalus monspessulanus L. was investigated using the DPPH radical scavenging and ferrous ion chelating assays. The n-butanol extract showed low (EC 50 = 2.09±0.434 mg mL -1 ) to moderate (IC 50 = 63.60±0.01 μg mL -1 ) antioxidant activities depending on the test method.

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Section: Resultsmentioning

confidence: 99%

Chemical composition and antioxidant activity of Astragalus monspessulanus L. growing in semiarid areas of Algeria

Bourezzane

Haba

Long

et al. 2018

JSCS

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“… 1998 ), and nicotiflorin (De Sousa et al. 2014 ), respectively. Their structure elucidation was performed by high resolution mass spectrometry, 1D- and 2D-NMR experiments and comparison with spectroscopic data reported in the literature.…”

Section: Resultsmentioning

confidence: 99%

Bioactive metabolites from the leaves of Withania adpressa

Bakrim

Bouzidi

Cretton

et al. 2018

Pharmaceutical Biology

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Context:Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties.Objective: To identify the compounds responsible for Withania adpressa Coss. antioxidant activity and further test them for their NF-κB inhibition and antiproliferative activity in multiple myeloma cells.Materials and methods: Compounds were obtained from the EtOAc extract of W. adpressa leaves. Structure elucidation was carried out mainly by 1D- and 2D-NMR, and mass spectrometry. Isolated compounds were tested in a dose-response for their in vitro NF-κB inhibition and antiproliferative activity in multiple myeloma cells after 5 and 72 h treatment, respectively.Results: The fractionation resulted in the isolation of a new glycowithanolide named wadpressine (5) together with withanolide F, withaferin A, coagulin L, and nicotiflorin. The latter showed a moderate ability to scavenge free radicals in DPPH (IC50 = 35.3 µM) and NO (IC50 = 41.3 µM) assays. Withanolide F and withaferin A exhibited low µM antiproliferative activity against both multiple myeloma cancer stem cells and RPMI 8226 cells. Furthermore, they inhibited NF-κB activity with IC50 values of 1.2 and 0.047 µM, respectively. The other compounds showed a moderate inhibition of cell proliferation in RPMI 8226 cells, but were inactive against cancer stem cells and did not inhibit NF-κB activity.Discussion and conclusions: One new glycowithanolide and four known compounds were isolated. Biological evaluation data gave further insight on the antitumor potential of withanolides for refractory cancers.

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“…The 1 H NMR spectrum showed two typical proton signals of a 5,7-substituted flavonol A-ring (d H 6. 21 2D NMR experiments were performed to determine the trisaccharide residue sequence. HSQC and heteronuclear multiple bond correlation (HMBC) spectra displayed important correlations between hydrogens and carbons of 1 (Figure 2), mainly of H-1"' (d H 4.50) and C-6" (d C 68.2) denoting a 1→6 linkage between the rhamnose and one of the glucose unit.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, compound 1 was unambiguously determinedas kaempferol-3-O-β-D-glucopyranosyl-(1→4)-a-Lrhamnopyranosyl-(1→6)-β-D-glucopyranoside.The structures of the known compounds (2-16) were determined by comparison of their physical and spectroscopic data with those of authentic samples and/or reported data in the literature. The known compounds were identified as kaempferol-3-O-robinobioside (2), 20 kaempferol-3-O-rutinoside (3),21 isorhamnetin-3-O-rutinoside (4),22 rutin (5),23 quercetin…”

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Flavonol Tri-O-glycoside and Other Chemical Constituents from Flowers of Aristolochia trulliformis

Holzbach¹,

Filho²,

Cunha³

et al. 2018

J. Braz. Chem. Soc.

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A new flavonol triglycoside, named kaempferol-3-O-β-D-glucopyranosyl-(1→4)-a-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside, was isolated from flowers of Aristolochia trulliformis (Aristolochiaceae) together with 15 known compounds, including six flavonoids and four lignans. The structures of the compounds were determined by spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) techniques and high-resolution mass spectrometry (HRMS).

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A New Flavonoid Derivative from Leaves ofOxandra sessilifloraR. E. Fries

Cited by 6 publications

References 0 publications

Chemical composition and antioxidant activity of Astragalus monspessulanus L. growing in semiarid areas of Algeria

Chemical composition and antioxidant activity of Astragalus monspessulanus L. growing in semiarid areas of Algeria

Bioactive metabolites from the leaves of Withania adpressa

Flavonol Tri-O-glycoside and Other Chemical Constituents from Flowers of Aristolochia trulliformis

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