Nanoparticle Mediated Electron Transfer Across Organic Layers: From Current Understanding to Applications

Gooding, J. Justin; Alam, Muhammad Tanzirul; Barfidokht, Abbas; Carter, Lachlan

doi:10.5935/0103-5053.20130306

Cited by 17 publications

(31 citation statements)

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“…We have previously shown that gold electrodes coated with BSA/rGOx/GA maintain a higher current density (84.5%) than when coated with BSA or BSA/GA, which is likely due to electron transfer medicated by the conducting nanoparticles in the rGOx containing composite. 19 When CV was used to compare gold electrodes that were modified with various coatings (BSA alone, BSA/GA without conducting nanoparticles, and BSA/prGOx/GA) that were exposed to 1% BSA for 24h, we found that the electrodes exhibited reduced electrochemical performance when uncoated or coated with composites without conducting nanoparticles ( Fig. 1e ).…”

Section: Ultra-fast Deposition Of An Antifouling Coating On Ec Sensorsmentioning

confidence: 98%

Rapid antifouling nanocomposite coating enables highly sensitive multiplexed electrochemical detection of myocardial infarction and concussion markers

S¹,

Durr²,

Yafia³

et al. 2021

Preprint

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Here we describe an ultra-fast (< 1 min) method for coating electrochemical (EC) sensors with an anti-fouling nanocomposite layer that can be stored at room temperature for months, which provides unprecedented sensitivity and selectivity for diagnostic applications. We leveraged this method to develop a multiplexed diagnostic platform for detection of biomarkers that could potentially be used to triage patients with myocardial infarction and traumatic brain injury using only 15 microliters of blood. Single-digit pg/mL sensitivity was obtained within minutes for all the biomarkers tested in unprocessed human plasma samples and whole blood, which is much faster and at least 50 times more sensitive than traditional ELISA methods, and the signal was stable enough to be measured after one week of storage. The multiplexed EC sensor platform was validated by analyzing 22 patient samples, which demonstrated excellent correlation with reported clinical values.

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Section: Ultra-fast Deposition Of An Antifouling Coating On Ec Sensorsmentioning

confidence: 98%

Rapid antifouling nanocomposite coating enables highly sensitive multiplexed electrochemical detection of myocardial infarction and concussion markers

S¹,

Durr²,

Yafia³

et al. 2021

Preprint

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“…The other important precedents for our findings relate to NP-mediated eT across insulating layers. Although first reported by Natan and co-workers , and then more thoroughly studied by Schiffrin and co-workers, − the interest in NP-mediated eT across ultrathin organic insulating layers picked up momentum in 2008 and 2009 when Fermin − and Gooding , independently reported that this type of eT is independent of insulating film thickness . In these early publications, both groups used adsorbed AuNPs to switch on faradaic eT reactions following passivation of an electrode with self-assembled monolayers .…”

Section: Introductionmentioning

confidence: 99%

Electron Transfer Facilitated by Dendrimer-Encapsulated Pt Nanoparticles Across Ultrathin, Insulating Oxide Films

2016

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Electrocatalytic oxygen reduction at carbon electrodes fully passivated by Al2O3 is reported. Specifically, pyrolyzed polymer film (PPF) electrodes were prepared and then coated with pinhole-free Al2O3 layers ranging in thickness from 2.5 to 5.7 nm. All of these ultrathin oxide film thicknesses completely passivated the PPF electrodes, resulting in no faradaic current for either inner-sphere or outer-sphere electrochemical reactions. The electrodes could, however, be reactivated by immobilizing Pt dendrimer-encapsulated nanoparticles (DENs), containing an average of 55 atoms each, on the oxide surface. These PPF/Al2O3/Pt DEN electrodes were completely stable under a variety of electrochemical and solution conditions, and they are active for simple electron-transfer reactions and for more complex electrocatalytic processes. This approach for preparing well-defined oxide electrodes opens the door to a better understanding of the effect of oxide supports on reactions electrocatalyzed by metal nanoparticles.

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“…Recent development of novel biorecognition molecules, such as synthetic aptamers, DNA, proteins, and viruses has enabled considerable selectivity in food analysis. Moreover, parallel development in the immobilization of bioreceptors through robust attachment methods like electro-deposition and nanoparticle-bound entities at the working electrode interface is a significant step in the improved application of biosensors in food analysis [ 28 , 29 , 30 , 31 , 32 , 33 ]. Selection of robust and suitable immobilization methodology and precise selection of the bioreceptor molecule plays a great part in the better specificity, selectivity, and affinity for their target analytes in electrochemical biosensing [ 10 ].…”

Section: Attributes Of Electrochemical Biosensor In Food Safety Anmentioning

confidence: 99%

Food Safety Analysis Using Electrochemical Biosensors

Mishra

Barfidokht

Tehrani

et al. 2018

Foods

Self Cite

144

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Rapid and precise analytical tools are essential for monitoring food safety and screening of any undesirable contaminants, allergens, or pathogens, which may cause significant health risks upon consumption. Substantial developments in analytical techniques have empowered the analyses and quantitation of these contaminants. However, conventional techniques are limited by delayed analysis times, expensive and laborious sample preparation, and the necessity for highly-trained workers. Therefore, prompt advances in electrochemical biosensors have supported significant gains in quantitative detection and screening of food contaminants and showed incredible potential as a means of defying such limitations. Apart from indicating high specificity towards the target analytes, these biosensors have also addressed the challenge of food industry by providing high analytical accuracy within complex food matrices. Here, we discuss some of the recent advances in this area and analyze the role and contributions made by electrochemical biosensors in the food industry. This article also reviews the key challenges we believe biosensors need to overcome to become the industry standard.

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Nanoparticle Mediated Electron Transfer Across Organic Layers: From Current Understanding to Applications

Cited by 17 publications

References 0 publications

Rapid antifouling nanocomposite coating enables highly sensitive multiplexed electrochemical detection of myocardial infarction and concussion markers

Rapid antifouling nanocomposite coating enables highly sensitive multiplexed electrochemical detection of myocardial infarction and concussion markers

Electron Transfer Facilitated by Dendrimer-Encapsulated Pt Nanoparticles Across Ultrathin, Insulating Oxide Films

Food Safety Analysis Using Electrochemical Biosensors

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