The Development and Validation of a Chiral High Performance Liquid Chromatography Method for the Identification and Quantification of (<i>R</i>)-Enantiomer in 10-Hydroxycamptothecin

Venkateshwarlu, A.; Rao, A. V. Rama; Mukkanti, K.; Reddy, S. V. Subba

doi:10.5935/0103-5053.20130271

Cited by 1 publication

(1 citation statement)

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“…have also been determined, especially in commercial products or biological samples (pharmaceutical formulations, human urine, human or animal blood, human plasma, animal serum, etc.). Another heterogeneous group of analytes, including connectors for building metal-organic frameworks [116,117,124], intermediates for the synthesis of pharmaceuticals [111], natural and synthetic compounds [39,113,121,120], biological compounds [82,112,58,71,78,86,[61][62][63]77,75], natural alkaloids [121], biomolecules [115,54], organometallic compounds [119] and chiral metabolites [103,108,100,97,102,59,63,52] has been enantioseparated with these immobilized polysaccharides CSPs (see Table 2-4). Fig.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

State-of-the-art and recent developments of immobilized polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid chromatography (2013–2017)

Padró

Keunchkarian

2018

Microchemical Journal

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Please cite this article as: Juan M. Padró, Sonia Keunchkarian , State-of-the-art and recent developments of immobilized polysaccharide-based chiral stationary phases for enantioseparations by high-performance liquid chromatography (2013)(2014)(2015)(2016)(2017). AbstractPolysaccharide-based chiral stationary phases have been recognized as one of the most powerful ones for high performance liquid chromatography (HPLC) separations of chiral compounds in analytical and also in preparative scale.Immobilized polysaccharide-based chiral stationary phases constitute a remarkable achievement due to their stable nature on working with standard or common solvents and also with those prohibited for using with coated phases.This review is mainly focused on the i. applications of these chiral stationary phases in numerous fields of HPLC separations; ii. comparative aspects between immobilized vs. coated polysaccharide-derived phases, and iii. revision of several theoretical studies such as enantiorecognition mechanism, mobile phase composition and column temperature effects.

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