Novel Bioactive Dibenzocyclooctadiene Lignans from<i>Schisandra neglecta</i>

Niu, De‐Yun; Meng, Chunyang; Yao, Fu-Quan; Zhou, Bin; Wang, Ruirui; Yang, Liu‐Meng; Zheng, Yong‐Tang; Hu, Qiu‐Fen; Sun, Han‐Dong; Xiao, Wei‐Lie

doi:10.5935/0103-5053.20130253

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Journal Of Asian Natural Products Research1

Cytotoxicity Assay1

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2014

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“…The cytotoxicities of 1 -9 were tested using a previously reported procedure [19]. All treatments were performed in triplicate.…”

Section: Journal Of Asian Natural Products Researchmentioning

confidence: 99%

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Isoflavanones from Desmodium oxyphyllum and their cytotoxicity

et al. 2014

Journal of Asian Natural Products Research

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Two new isoflavanones, (3R)-7-hydroxy-4'-methoxy-5-methoxycarbonyl-isoflavanone (1) and (3R)-8-hydroxy-4'-methoxy-7-methoxycarbonyl-isoflavanone (2), together with seven known isoflavanones (3-9) were isolated from Desmodium oxyphyllum of the Leguminosae family. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 1 showed good cytotoxicity against NB4 and SHSY5Y cell lines with IC50 values of 3.1 and 2.5 μM; compound 2 exhibited cytotoxicity against PC3 cell lines with a IC50 value of 3.6 μM; compound 4 showed cytotoxicity against A549 and SHSY5Y cell lines with IC50 values of 3.6 and 2.8 μM; and compound 5 displayed cytotoxicity against NB4, SHSY5Y, and MCF7 cell lines with IC50 values of 2.6, 3.8, and 2.8 μM, respectively. Other compounds also showed moderate cytotoxicity for some tested cell lines with IC50 values between 5.4 and 8.8 μM.

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“…The cytotoxicities of 1 -9 were tested using a previously reported procedure [19]. All treatments were performed in triplicate.…”

Section: Journal Of Asian Natural Products Researchmentioning

confidence: 99%

“…The cytotoxicity tests for the isolates were carried out by MTT assay (with taxol as the positive control) against NB4, A549, SHSY5Y, PC3, and MCF7 tumor cell lines [19].…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Isoflavanones from Desmodium oxyphyllum and their cytotoxicity

et al. 2014

Journal of Asian Natural Products Research

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Novel Bioactive Dibenzocyclooctadiene Lignans fromSchisandra neglecta

Cited by 1 publication

References 1 publication

Isoflavanones from Desmodium oxyphyllum and their cytotoxicity

Isoflavanones from Desmodium oxyphyllum and their cytotoxicity

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