Tryptophan Determination at Carbon Fiber Ultramicroelectrodes by Fast-Scan Cyclic Voltammetry

Fiorucci, Antonio Rogério; Cervini, Priscila; Fatibello‐Filho, Orlando; Cavalheiro, Éder Tadeu Gomes

doi:10.5935/0103-5053.20130156

Cited by 1 publication

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“…Besides the aforesaid reports whose aim was mainly promoting the sensitivity of Trp sensors and, concurrently, addressing other critical issues, i.e., selectivity and electrode fouling, other reports are found in the literature that aimed at reducing the analysis time [ 201 , 217 ] and/or the cost [ 49 , 102 ] of the sensors. The reports on electrochemical Trp measurement, since 2010, were collected and tabulated and are presented in Table 4 .…”

Section: Electrochemical Analysis Of Amino Acidsmentioning

confidence: 99%

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Moulaee

Neri

2021

Biosensors

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The rapid growth of research in electrochemistry in the last decade has resulted in a significant advancement in exploiting electrochemical strategies for assessing biological substances. Among these, amino acids are of utmost interest due to their key role in human health. Indeed, an unbalanced amino acid level is the origin of several metabolic and genetic diseases, which has led to a great need for effective and reliable evaluation methods. This review is an effort to summarize and present both challenges and achievements in electrochemical amino acid sensing from the last decade (from 2010 onwards) to show where limitations and advantages stem from. In this review, we place special emphasis on five well-known electroactive amino acids, namely cysteine, tyrosine, tryptophan, methionine and histidine. The recent research and achievements in this area and significant performance metrics of the proposed electrochemical sensors, including the limit of detection, sensitivity, stability, linear dynamic range(s) and applicability in real sample analysis, are summarized and presented in separate sections. More than 400 recent scientific studies were included in this review to portray a rich set of ideas and exemplify the capabilities of the electrochemical strategies to detect these essential biomolecules at trace and even ultra-trace levels. Finally, we discuss, in the last section, the remaining issues and the opportunities to push the boundaries of our knowledge in amino acid electrochemistry even further.

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