Green and Selective Synthesis ofN-Substituted Amides using Water Soluble Porphyrazinato Copper(II) Catalyst

A novel 3-acetoxy-2-methyl-N-(4-methoxyphenyl)benzamide: Molecular structural describe, antioxidant activity with use X-ray diffractions and DFT calculations

“…A C C E P T E D ACCEPTED MANUSCRIPT 3 A novel 3-acetoxy-2-methyl-N-(4-methoxyphenyl) benzamide was synthesized starting from 3-acetoxy-2-methylbenzoic acid and 4-methoxyaniline. In the determination of the structure of this synthesized compound by FT-IR spectroscopy and single crystal-XRD elemental analysis techniques have been used.…”

“…peptides and proteins) [1][2][3][4][5][6][7][8][9] and potential drug compounds that contain an amide bond [10][11][12][13], such as acetaminophen (analgesic), lidocaine (Xylocaine, local anaesthetic) loperamide (Imodium AD, anti-diarrheal) [1,2], atorvastatin (cholesterollowering) [14], lisinopril (inhibitor of angiotensin converting enzyme) [15], valsartan (blockade of angiotensin-II receptors) [16], and diltiazem (calcium channel blocker used in the treatment of angina and hypertension) [17]. Amides represent an important class of compounds found in numerous bioactive products such as sorafenib [18], lipitor [19] and vyvanse [20], which have been widely used for the treatment of cancer, hypercholesterolemia, and juvenile hyperactivity, respectively [21].…”

Ruthenium-Catalyzed Amide-Bond Formation

“…Mechanistic studies by Duchateau and co-workers, employing the [RuH 2 (PPh 3 ) 4 ]-catalyzed hydrolytic amidation of pentanenitrile with n-hexylamine as model reaction, pointed out that the process proceeds through the initial hydration of the nitrile to form an intermediate primary amide, which subsequently reacts with the amine to give the final N-substituted amide product (parth (a) in Scheme 14) [79]. This reaction pathway contrasts with that commonly proposed for other homogeneous metal catalysts (Pt-, Cu-Zn-or Fe-based systems) where an amidine intermediate, which evolves into the final amide product by hydrolysis, is initially formed (parth (b) in Scheme 14) [71,73,[75][76][77]. …”

“…In this context, although little studied, the catalytic amidation of nitriles with amines in the presence of water has emerged in recent years as a useful tool for the straightforward generation of secondary and tertiary amides (Scheme 10) [71][72][73][74][75][76][77]. This amidation reaction was reported for the first time by Murahashi and coworkers in 1986 using the unique ruthenium catalyst described so far for this catalytic transformation [78].…”

Copper immobilized on aminated ferrite nanoparticles by 2‐aminoethyl dihydrogen phosphate (Fe3O4@AEPH2‐CuII) catalyses the conversion of aldoximes to nitriles

“…In continuation of our recent studies of the application of Cu II in organic reactions, after preparation and characterization of Fe 3 O 4 @AEPH 2 ‐Cu II , its catalytic activity as a new magnetic nanocatalyst was investigated in the preparation of a library of nitriles through dehydration of aldoximes by acetonitrile (Scheme ).…”