An Enhanced Electrochemical Sensing Platform Integrated with Graphene Oxide and Iron Hydroxide Colloid for Sensitive Determination of Phloroglucinol

Li, Junhua; Kuang, Dai‐Zhi; Ye, Feng; Liu, Mengqin; Zhang, Fuxing; Deng, Peihong

doi:10.5935/0103-5053.20130077

Cited by 3 publications

(3 citation statements)

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“…The relative standard deviation (RSD) value was found to be less than 3%, indicating that the sensing platform provides excellent performance in actual sample detection. 64 The selective biomolecular sensing is the most significant features in practical applications. The interference study was carried out to determine the selectivity of AChE/CSNPs/GCE (0.15 wt %) in detecting ACh in the presence of other biomolecules and inorganic salts such as AA, DA, UA, KCl, NaCl, and MgCl 2 by amperometric measurements, as shown in Figure S16.…”

Section: Resultsmentioning

confidence: 99%

“…As the data showed a satisfactory recovery range of 99–101.3% in blood serum samples, the present investigations demonstrate high throughput and accuracy in the detection of ACh. The relative standard deviation (RSD) value was found to be less than 3%, indicating that the sensing platform provides excellent performance in actual sample detection …”

Section: Results and Discussionmentioning

confidence: 99%

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Gradient Triple-Layered ZnS/ZnO/Ta₂O₅–SiO₂ Core–Shell Nanoparticles for Enzyme-Based Electrochemical Detection of Cancer Biomarkers

Murugan

Sundramoorthy

et al. 2020

ACS Appl. Nano Mater.

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We report a methodology to fabricate unique threelayered ZnS/ZnO/Ta 2 O 5 (core)−SiO 2 (shell) nanoparticles (CSNPs) with varying compositions of ZnS, ZnO, Ta 2 O 5 , and SiO 2 in their layers (i.e., gradient structures). An electrochemical approach with better specificity and detection limit for nonneurally secreted cancer biomarker, acetylcholine (ACh), by modifying the glassy carbon electrode surface with enzyme tagged ZnS/ZnO/Ta 2 O 5 −SiO 2 CSNPs is reported. The size, composition, porosity, and morphology of CSNPs were characterized by using scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, Brunauer−Emmett−Teller (BET) surface area analysis, X-ray diffraction technique, and Fourier-transform infrared spectroscopy. A detailed discussion on the mechanism of core−shell formation and the role of ZnCl 2 in the core−shell formation is reported. We also demonstrate that the detection limit of ACh could be significantly improved by controlling the thickness of outermost shell layer. Electrochemical investigations performed using differential pulse voltammetry and cyclic voltammetry techniques displayed that the oxidation current of ACh was higher for CSNPs synthesized at 0.15 wt % of ZnCl 2 concentration. The limit of detection of ACh was found to be 11.6 nM for CSNPs prepared at 0.15 wt % ZnCl 2 concentration. Thus, the CSNPs-based electrochemical sensor platform has high potential for developing a simple, cost-effective biosensor for early detection of cancer biomarker at nanomolar concentration.

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Section: Resultsmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Gradient Triple-Layered ZnS/ZnO/Ta₂O₅–SiO₂ Core–Shell Nanoparticles for Enzyme-Based Electrochemical Detection of Cancer Biomarkers

Murugan

Sundramoorthy

et al. 2020

ACS Appl. Nano Mater.

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“…Existing methods in analysing PL such as chemiluminescence, high-performance liquid chromatography (HPLC/MS), and thinlayer chromatography, ion chromatography [8][9][10][11], etc are time-consuming and costly techniques. Few electroanalytical methods were also reported previously such as graphene oxide and iron hydroxide colloid modified glassy carbon electrode [12], ZnO⎯N-(tri methoxy silyl propyl) ethylenediamine tri acetic acid modified glassy carbon electrode [13] Surfactant/MWCNTS/Glassy carbon [14].…”

Section: Introductionmentioning

confidence: 99%

Optimized Voltammetric Experiment for the Determination of Phloroglucinol at Surfactant Modified Carbon Nanotube Paste Electrode

Tigari

Manjunatha

2020

Instrum Exp Tech

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Present work describes the electrochemical sensing and determination of phenolic compound (Phloroglucinol) using non-ionic surfactant Octyl phenol ethoxylate modified carbon nanotube paste electrode (OPEMCNTPE) in PBS (0.1 mol, pH 6.0) by Voltammetric method. The developed electrode was characterized by field emission scanning electron microscope (FE-SEM) and cyclic voltammetric (CV) studies. The OPEMCNTPE shows an exceptional catalytic impact towards the electro-oxidation of Phloroglucinol (PL) in contrast to the bare carbon nanotube paste electrode (BCNTPE). The rise in the concentration of PL is directly proportional to PL anodic peak current in the linear working range 10-90 μmol with a small detection limit (LOD) 0.71 μmol. This method was utilized for the estimation of PL in the water and blood serum samples.

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Electrochemical and QSPR studies of several hydroxy- and amino-polysubstituted benzenes constituents of useful compounds

et al. 2020

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An Enhanced Electrochemical Sensing Platform Integrated with Graphene Oxide and Iron Hydroxide Colloid for Sensitive Determination of Phloroglucinol

Cited by 3 publications

References 0 publications

Gradient Triple-Layered ZnS/ZnO/Ta₂O₅–SiO₂ Core–Shell Nanoparticles for Enzyme-Based Electrochemical Detection of Cancer Biomarkers

Gradient Triple-Layered ZnS/ZnO/Ta₂O₅–SiO₂ Core–Shell Nanoparticles for Enzyme-Based Electrochemical Detection of Cancer Biomarkers

Optimized Voltammetric Experiment for the Determination of Phloroglucinol at Surfactant Modified Carbon Nanotube Paste Electrode

Electrochemical and QSPR studies of several hydroxy- and amino-polysubstituted benzenes constituents of useful compounds

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An Enhanced Electrochemical Sensing Platform Integrated with Graphene Oxide and Iron Hydroxide Colloid for Sensitive Determination of Phloroglucinol

Cited by 3 publications

References 0 publications

Gradient Triple-Layered ZnS/ZnO/Ta2O5–SiO2 Core–Shell Nanoparticles for Enzyme-Based Electrochemical Detection of Cancer Biomarkers

Gradient Triple-Layered ZnS/ZnO/Ta2O5–SiO2 Core–Shell Nanoparticles for Enzyme-Based Electrochemical Detection of Cancer Biomarkers

Optimized Voltammetric Experiment for the Determination of Phloroglucinol at Surfactant Modified Carbon Nanotube Paste Electrode

Electrochemical and QSPR studies of several hydroxy- and amino-polysubstituted benzenes constituents of useful compounds

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Product

Resources

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Gradient Triple-Layered ZnS/ZnO/Ta₂O₅–SiO₂ Core–Shell Nanoparticles for Enzyme-Based Electrochemical Detection of Cancer Biomarkers

Gradient Triple-Layered ZnS/ZnO/Ta₂O₅–SiO₂ Core–Shell Nanoparticles for Enzyme-Based Electrochemical Detection of Cancer Biomarkers