An update on pathology of IgA nephropathy

Soares, Maria Fernanda

doi:10.5935/0101-2800.20160069

Cited by 10 publications

(11 citation statements)

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“…Polymeric IgA1 deposited in the mesangial of kidney leads to IgA nephropathy (IgAN). This is one of the most common cause of glomerulonephritis all around the world . Studies showed that IgAN was associated with an increase in B cells number and the incompletely galactosylation of O‐glycans in IgA1.…”

Section: The Role Of Mir‐374 In Kidney Diseasementioning

confidence: 99%

The latest progress on miR‐374 and its functional implications in physiological and pathological processes

Bian

Zhou

et al. 2019

J Cellular Molecular Medi

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Non‐coding RNAs (ncRNAs) have been emerging players in cell development, differentiation, proliferation and apoptosis. Based on their differences in length and structure, they are subdivided into several categories including long non‐coding RNAs (lncRNAs >200nt), stable non‐coding RNAs (60‐300nt), microRNAs (miRs or miRNAs, 18‐24nt), circular RNAs, piwi‐interacting RNAs (26‐31nt) and small interfering RNAs (about 21nt). Therein, miRNAs not only directly regulate gene expression through pairing of nucleotide bases between the miRNA sequence and a specific mRNA that leads to the translational repression or degradation of the target mRNA, but also indirectly affect the function of downstream genes through interactions with lncRNAs and circRNAs. The latest studies have highlighted their importance in physiological and pathological processes. MiR‐374 family member are located at the X‐chromosome inactivation center. In recent years, numerous researches have uncovered that miR‐374 family members play an indispensable regulatory role, such as in reproductive disorders, cell growth and differentiation, calcium handling in the kidney, various cancers and epilepsy. In this review, we mainly focus on the role of miR‐374 family members in multiple physiological and pathological processes. More specifically, we also summarize their promising potential as novel prognostic biomarkers and therapeutic targets from bench to bedside.

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Section: The Role Of Mir‐374 In Kidney Diseasementioning

confidence: 99%

The latest progress on miR‐374 and its functional implications in physiological and pathological processes

Bian

Zhou

et al. 2019

J Cellular Molecular Medi

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“…IgAN is characterized by codominance or dominance of polymeric IgA1 in mesangial deposition that originates from circulating IgA1‐containing polymeric IgA1 or immune complexes . However, IgAN was considered as one complex multifactorial disease, immunology and genetics mechanisms were proved to play critical roles in the development and pathogenesis of IgAN . Growing evidences suggested that B lymphocytes were increased in cases with high concentration of the IgA in the serum .…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8] Growing evidences suggested that B lymphocytes were increased in cases with high concentration of the IgA in the serum. 6,9 IgA1 in the serum is abnormally O-glycosylated, which causes IgA1 mesangial deposition and glomerular injury developing into IgAN. 10,11 MicroRNAs (miRNAs) are a group of single-stranded, noncoding, and short (21 to 23 nucleotides) RNA molecules that regulate gene expression through binding to 3′UTR of mRNAs of the protein coding genes.…”

Section: Introductionmentioning

confidence: 99%

MiR‐320 promotes B cell proliferation and the production of aberrant glycosylated IgA1 in IgA nephropathy

Shi

Zhao

2018

J of Cellular Biochemistry

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IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. However, the etiology of this disease is complex and the pathogenesis of IgAN is still unknown. MicroRNAs (miRNAs) play important roles in a lot of pathological and physiological processes. In this study, we showed that the expression of miR-320 was significantly upregulated in renal tissues and urinary of IgAN patients. Moreover, the intra-renal expression level of miR-320 had significant correlation with miR-320 expression in the urinary of IgAN patients. Overexpression of miR-320 increased B cell proliferation and promoted cyclin D1 expression. Furthermore, we identified that PTEN was direct target gene of miR-320 in the B cell. Ectopic expression of miR-320 suppressed PTEN expression. Overexpression of miR-320 decreased Cosmc expression in the B cell. In addition, we demonstrated that Cosmc expression was significantly downregulated in the renal tissues and urinary of IgAN patients. The intra-renal expression level of Cosmc had significant correlation with Cosmc expression of urinary in IgAN patients. We proved that the expression level of Cosmc was negatively correlated with the expression of miR-320 in the renal tissues of IgAN patients. Overexpression of miR-320 promoted the B cell proliferation through suppressing PTEN expression. Taken together, these data suggested that miR-320 acted an important role in the development of IgAN.

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“…The combined maximal score of this classification (MEST score) was 5 points (M1+E1+S1+T2) and renal lesions with a sum score of two or higher were accepted as having an independent risk factor for progression to ESRD for IgAN patients [7]. In addition, each of these 4 separate lesions was proposed as having an independent value as a risk factor for progression to ESRD [8]. S1 lesion was found to be associated with the presence of higher proteinuria levels and better response to immunosuppressive treatment [9].…”

Section: Introductionmentioning

confidence: 99%

Combining clinical features and MEST-C score in IgA nephropathy may be a better determinant of kidney survival

Yeter

Gönül

Güz

et al. 2020

Romanian Journal of Internal Medicine

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Introduction: IgA nephropathy (IgAN) is a heterogeneous disease with highly variable clinical and histopathological features. We investigated the effects of Oxford classification and clinical features on renal survival in patients with IgAN.Methods: This retrospective observational study conducted from 2013 to 2017. Ninety-seven patients who were followed up more than six months were examined.Results: A total of 97 patients (68% male and median age 40 years) were enrolled in this study. 13% of patients developed end stage renal disease (ESRD) within the median of 37 months of follow-up. Need for renal replacement therapy at the time of diagnosis, serum creatinine level of higher than 1.97 mg/dl, serum albumin level less than 3.5 gr/dl, 24-hour urine protein level of higher than>3.5 g/day, the percentage of glomerulosclerosis higher than 53%, T2 score and total MEST-C score higher than two were found to be significant predictors of development of ESRD. None of the clinical or histopathological features were found to be significant predictor of steroid treatment sensitivity except T1-2 scores.Conclusion: We think that IgA nephropathy is a heterogeneous disease that requires clinical and histopathological features to be evaluated together, but not individually, to determine renal survival.

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An update on pathology of IgA nephropathy

Cited by 10 publications

References 0 publications

The latest progress on miR‐374 and its functional implications in physiological and pathological processes

The latest progress on miR‐374 and its functional implications in physiological and pathological processes

MiR‐320 promotes B cell proliferation and the production of aberrant glycosylated IgA1 in IgA nephropathy

Combining clinical features and MEST-C score in IgA nephropathy may be a better determinant of kidney survival

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