Are PTH levels related to oxidative stress and inflammation in chronic kidney disease patients on hemodialysis?

Jaqueto, Marcel; Delfino, Vinícius Daher Alvares; Bortolasci, Chiara C.; Barbosa, Décio Sabbatini; Morimoto, Helena Kaminami; Frange, Raquel Ferreira Nassar; Guimarães, Fernanda Burle dos Santos

doi:10.5935/0101-2800.20160045

Cited by 15 publications

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“…This progressive pathophysiological process is attributed to uremia, which leads to a decrease in the proportion of contractile tissue in the sarcomere and, consequently, contractile inefficiency [4,8,28]. In the present study, the PF parameters of dialysis patients declined by more than 10% when compared to predicted values reported in the literature (Table 2), corroborating prior research [19,29].…”

Section: Discussionsupporting

confidence: 91%

“…The parameters assessed were distance walked, respiratory rate (RR), blood pressure (BP), heart rate (HR), oxygen saturation (SpO2) and degree of dyspnea and fatigue by the Modified Borg Scale. The vital signs were measured before the test and in the first and second minute after its completion [18,19]. The predicted distance walked (%) in the 6MWT was calculated using the equation for the Brazilian population developed by Britto [20].…”

Section: Methodsmentioning

confidence: 99%

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Effect of parathyroid hormone levels on the functional capacity and pulmonary function of patients on dialysis

2020

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Introduction: Chronic kidney disease is characterized as the gradual loss of kidney function, with patients on dialysis experiencing a decline in functional capacity and pulmonary function. One of the non-traditional risk factors is parathyroid hormone (PTH), which influences metabolism and the status of the disease. Objective: Assess the effect of parathyroid hormone levels on functional capacity and pulmonary function in patients on dialysis. Method: Cross-sectional study with hemodynamically stable dialysis patients of both sexes, aged 18 to 59 years, who did not gain more than 2.5kg between dialysis sessions. Two groups were created according to PTH blood levels: PTH (A), with values outside the normal range, and PTH (C), who exhibited normal levels of the hormone. Pulmonary function (PF) was assessed by spirometry and functional capacity (FC) via the six-minute walk test (6MWT). Results: The PTH A group displayed a negative association between PTH levels and PF, based on the values obtained for the spirometric variables forced expiratory volume in 1 second (FEV1) (r = -0.54) and forced vital capacity (FVC) (r= -0.69). The average distance walked by the PTH (C) group was 343.85 ± 98.14 meters. Conclusion: The results suggest that high PTH levels have a negative effect on the PF of patients on dialysis.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Effect of parathyroid hormone levels on the functional capacity and pulmonary function of patients on dialysis

2020

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“…Therefore, the reduction in inflammation in HD patients after calcitriol oral administration is unlikely to be due to improvement in PTH level. However, the results of another descriptive study suggested that the oxidative stress and inflammation of HD patients might have arisen from mechanisms other than SHPT [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Patients at the end-stage renal disease have higher levels of oxidative stress and inflammation than the normal population. Several factors contributed to these issues, wherein the parathyroid hormone is also implicated [ 33 ]. Consistent with these studies, higher levels of inflammatory markers ( i.e.…”

Section: Discussionmentioning

confidence: 99%

Redox State of Human Serum Albumin and Inflammatory Biomarkers in Hemodialysis Patients with Secondary Hyperparathyroidism During Oral Calcitriol Supplementation for Vitamin D

Nasif¹,

Mukhtar²,

El-Emshaty³

et al. 2018

TOMCJ

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Background:Hemodialysis (HD) patients with secondary Hyperparathyroidism (s-HPT) are exposed to increased inflammation and oxidative stress. In HD patients, oxidized albumin is a reliable marker of oxidative stress and its clinical significance has been rarely studied.Objective:The objective of this study was to evaluate Cys34 Human Serum Albumin (HSA) as oxidative stress biomarker in HD patients with s-HPT and its relationship with inflammation on bone turnover markers during oral calcitriol supplementation for vitamin D.Patients and Methods:Fifteen stable hemodialysis patients with s-HPT (mean age 48.67±8.15, 11 males and 4 females) were used in the experiment to receive calcitriol treatment for 16 weeks (0.25mcg or 0.5 mcg once a day according to serum level of Ca and P for each). The changes in the serum biochemical parameters (Ca, P, ALP, and iPTH), inflammatory markers (CRP and IL-6 levels) and serum oxidative stress condition (SOD, IS and albumin ratio HNA/HMA) were evaluated before and at 8 and 16 weeks of calcitriol treatment. The correlations between those factors were studied.Results:All patients responded to oral calcitriol therapy, with a significant decrease in the serum iPTH. The results showed that calcitriol could effectively suppress iPTH secretion with a significant elevation of serum Ca and P but ALP remained unchanged during the study. It can also effectively reduce the inflammatory markers (CRP and IL-6), while increasing the oxidative markers (SOD and IS). Oxidative albumin ratio HNA/HMA showed a significant (p=0.001) reduction after 16 weeks of calcitriol treatment and the redox state of HSA showed a positive prediction for hyperparathyroidism and for inflammation.Conclusion:The redox state of HSA could be used as a predictor for monitoring hyperparathyroidism and inflammation during calcitriol treatment by retarding albumin oxidation in HD patients with secondary hyperparathyroidism.

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“…Para as análises de No entanto foi observerdo que os níveis de PTH causaram um efeito negativo sobre a função musculoesquelética. Em relação a capacidade funcional física a distância média percorrida e a % do previsto obtida pelo grupo PTH (C) foram de 343,85 ± 98,14 metros e 42,35% enquanto as obtidas pelo grupo PTH (A) foram de 385,60 ± 94,14 metros e 47,04 %, respectivamente.No nosso estudo, a distância percorrida em metros pelos voluntários de ambos os grupos foi inferior a distância predita e ao limite inferior de normalidade da referência brasileira para o TC6, o que pode ser justificado pelo fato dos integrantes de ambos os grupos independentemente dos níveis séricos de PTH estarem em tratamento hemodialítico(JAQUETO et al, 2016).Dentre as limitações da nossa investigação podemos citar o tamanho amostral e a inexistência de um grupo controle sem a DRC. Entretanto, foram avaliados todos os pacientes elegíveis do Centro de Hemodiálise e os grupos foram pareados de acordo com as variáveis antropométricas, sexo e idade.Além disso, nossos achados evidenciam uma importante consequência do aumento dos níveis de PTH, que ainda não havia sido observada na literatura.O presente estudo demonstrou que os níveis de PTH não interferiram na capacidade física.Entretanto, os pacientes dialíticos mostraram importante comprometimento da capacidade funcional física.REFERÊNCIASATS -Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories.ATS statement: guidelines for the six-minute walk test.…”

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Efeito dos níveis de paratormônio sobre a capacidade funcional física de pacientes dialíticos

Franco

Lovatto

Ferreira

et al. 2019

BJD

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Are PTH levels related to oxidative stress and inflammation in chronic kidney disease patients on hemodialysis?

Abstract: Neste estudo descritivo, os resultados sugerem que a inflamação e o estresse oxidativo em pacientes em hemodiálise provavelmente tem origem em mecanismos que não incluem o hiperparatireoidismo secundário.

Cited by 15 publications

References 0 publications

Effect of parathyroid hormone levels on the functional capacity and pulmonary function of patients on dialysis

Effect of parathyroid hormone levels on the functional capacity and pulmonary function of patients on dialysis

Redox State of Human Serum Albumin and Inflammatory Biomarkers in Hemodialysis Patients with Secondary Hyperparathyroidism During Oral Calcitriol Supplementation for Vitamin D

Efeito dos níveis de paratormônio sobre a capacidade funcional física de pacientes dialíticos

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