Erythropoietin resistance in end-stage renal disease patient with gastric antral vascular ectasia

Lee, Desiree Ji Re; Fragata, Juliana; Pestana, José Osmar Medina; Draibe, Sérgio Antônio; Canziani, María Eugênia Fernandes; Cendoroglo, Miguel; Júnior, Miguel Ângelo de Góes

doi:10.5935/0101-2800.20150042

Cited by 4 publications

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“…Finally, regardless of the factors contributing to anemia in kidney disease 3 – 6 , 48 , some anemia-related factors were related to outcomes such as DGF, CAD, and death in deceased donor kidney transplantation. These findings can help the interpretation and management of those patients’ outcomes; consequently, the anemia tests could assist nephrologists with decision-making during treatment.…”

Section: Discussionmentioning

confidence: 95%

Relationship of hemoglobin levels with outcomes in deceased donor kidney transplant: a retrospective cohort study

Silva,

Macedo,

Hayano

et al. 2024

Braz. J. Nephrol.

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Introduction: Anemia is frequent in patients undergoing replacement therapy for kidney failure. Anemia in the pre- and post-transplantation period might be related to kidney transplant outcomes. The current study therefore sought to assess the relationship between anemia, delayed allograft function (DGF), chronic kidney allograft dysfunction (CAD), and death from any cause following kidney transplantation from a deceased donor. Methods: This was a retrospective study with 206 kidney transplant patients of deceased donors. We analyzed deceased donors’ and kidney transplant patients’ demographic data. Moreover, we compared biochemical parameters, anemia status, and medicines between DGF and non-DGF groups. Afterward, we performed a multivariate analysis. We also evaluated outcomes, such as CAD within one year and death in ten years. Results: We observed a lower frequency of pre-transplant hemoglobin concentration (Hb) but higher frequency of donor-serum creatinine and red blood transfusion within one week after transplantation in the group with DGF. In addition, there was an independent association between Hb concentration before transplantation and DGF [OR 0.252, 95%CI: 0.159–0.401; p < 0.001]. There was also an association between Hb concentration after six months of kidney transplantation and both CAD [OR 0.798, 95% CI: 0.687–0.926; p = 0.003] and death from any cause. Conclusion: An association was found between pre-transplantation anemia and DGF and between anemia six months after transplantation and both CAD and death by any cause. Thus, anemia before or after transplantation affects the outcomes for patients who have undergone kidney transplantation from a deceased donor.

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Section: Discussionmentioning

confidence: 95%

Relationship of hemoglobin levels with outcomes in deceased donor kidney transplant: a retrospective cohort study

Silva,

Macedo,

Hayano

et al. 2024

Braz. J. Nephrol.

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“…However, the absence of the characteristic watermelon appearance does not entirely exclude the presence of GAVE, as the literature review shows that many patients required more than 1 endoscopy to confirm the presence of GAVE. Moreover, 7 cases (22.5%) in the literature review did not report this finding and were diagnosed based on clinical picture [ 12 – 16 ].…”

Section: Discussionmentioning

confidence: 99%

Successful Surgical Management of Gastric Antral Vascular Ectasia in a Patient with End-Stage Renal Disease: A Case Report and Literature Review

et al. 2023

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Patient: Female, 54-year-old Final Diagnosis: Gastric antral vascular ectasia Symptoms: Anemia Clinical Procedure: Endoscopic argon plasma coagulation • laparoscopic subtotal gastrectomy Specialty: Gastroenterology and Hepatology • Surgery Objective: Unknown etiology Background: Gastric antral vascular ectasia (GAVE) is a rare clinical entity that presents with acute upper-gastrointestinal bleeding or chronic anemia. It is characterized by endoscopic watermelon appearance of the stomach. It is usually associated with other comorbidities; however, few articles have previously described GAVE in patients with end-stage renal disease. Its management is controversial, and endoscopic management is considered the treatment of choice. Case Report: A middle-age female patient, on regular hemodialysis for ESRD, was referred to the surgical out-patient clinic as a refractory GAVE after failure of endoscopic management as she became blood transfusion-dependent. She underwent laparoscopic subtotal gastrectomy with a Billroth II reconstruction of gastrojejunostomy. She had a smooth postoperative course and was followed up in the clinic for 12 months with no complications. Her hemoglobin level was stable at 9.4 g/dL without further blood transfusion. Conclusions: Gastric antral vascular ectasia is usually associated with other comorbidities; however, an association between GAVE and CKD is rare. Its management is controversial, and endoscopic management is considered the preferred method of treatment. Laparoscopic subtotal gastrectomy is an effective management modality for GAVE, with dramatic improvement and good outcomes in terms of bleeding, blood transfusion requirements, and nutritional status.

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“…Tai ypač svarbu nepavykus iš-gydyti anemijos geležies preparatais arba eritropoetinu, nes kraujuojant iš ektazijų, greitai netenkama geležies atsargų [4]. Fuccio ir kt.…”

Section: Atvejo Aptarimasunclassified

Skrandžio Urvo Kraujagyslių Ektazija Ir Lėtinė Inkstų Liga: Klinikinis Atvejis

Lavinskas

Jucaitis²,

Miglinas

et al. 2017

Medicinos Teorija Ir Praktika

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SANTRAUKAReikšminiai žodžiai: skrandžio urvo kraujagyslių ektazija, lėtinė inkstų liga, dializė. Skrandžio urvo kraujagyslių ektazija yra reta polietiologinė skrandžio gleivinės ir kraujagyslių patologija, neretai sukelianti gyvybei pavojingą kraujavimą. Ši liga dažnai pasitaiko pacientams, sergantiems sistemine skleroze, kepenų ciroze ar Sjogreno sindromu. Pastebėta, jog sergantieji lėtine inkstų liga dažniau susiduria su kraujavimu dėl skrandžio urvo kraujagyslių ektazijos. Šiame straipsnyje aprašomas klinikinis atvejis apie 66 metų pacientę, sergančią 5 stadijos lėtine inkstų liga bei skrandžio urvo kraujagyslių ektazija. Per vienerius metus pacientei dėl kraujavimo iš kraujagyslių ektazijų atliktos 4 argono plazmos koaguliacijos. Nepaisant hemodializių, pacientei atsinaujindavo kraujavimas iš viršutinio virškinamojo trakto. ABSTRACTKey words: gastric antral vascular ectasia, chronic kidney disease, dialysis. Gastric antral vascular ectasia is recognised as a rare cause of upper gastrointestinal bleeding. Gastric antral vascular ectasia is often found in patients with systemic sclerosis, cirrhosis of the liver or Sjogren's syndrome. Additionally, it was observed that patients with chronic renal diseases are more tend to have gastric antral vascular ectasia. We present a case of 66 year old woman with stage 5 of chronic renal disease, undergoing dialysis for 3 years and suffering from recurring gastrointestinal bleeding caused by Gastric antral vascular ectasia. The patient was treated with Argon plasma coagulation overall 4 times in 1 year period, the dialysis were proceeded on. Despite of dialysis treatment, the patient suffered from renewed Gastric antral vascular ectasia and upper gastrointestinal bleeding. ĮVADASSkrandžio urvo kraujagyslių ektazija (angl. "Gastric antral vascular ectasia", GAVE) -tai reta skrandžio gleivinės ir kraujagyslių liga, sukelianti ūmų arba lėtinį kraujavimą iš viršutinio virškinamojo trakto. Apskaičiuota, jog skrandžio urvo kraujagyslių ektazija gali lemti net 4 proc. retų kraujavimų iš viršutinio virškinamojo trakto. Statistiškai dažniau skrandžio urvo kraujagyslių ektazija serga vyresnės nei 70 metų moterys [1].Neretai skrandžio urvo kraujagyslių ektazija diagnozuojama pacientams, sergantiems cukriniu diabetu, sistemine skleroze, Sjogreno sindromu, pirmine biliarine ciroze arba Reynauld fenomenu. Manoma, jog skrandžio urvo krauja-

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Erythropoietin resistance in end-stage renal disease patient with gastric antral vascular ectasia

Cited by 4 publications

References 0 publications

Relationship of hemoglobin levels with outcomes in deceased donor kidney transplant: a retrospective cohort study

Relationship of hemoglobin levels with outcomes in deceased donor kidney transplant: a retrospective cohort study

Successful Surgical Management of Gastric Antral Vascular Ectasia in a Patient with End-Stage Renal Disease: A Case Report and Literature Review

Skrandžio Urvo Kraujagyslių Ektazija Ir Lėtinė Inkstų Liga: Klinikinis Atvejis

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