Collapsing variant of focal segmental glomerulosclerosis by parvovirus B19: Case report

Freitas, Geraldo Rubens Ramos de; Praxedes, Marcel Rodrigues Gurgel; Malheiros, Denise; Testagrossa, Leonardo; Dias, Cristiane Bitencourt; Woronik, Viktoria

doi:10.5935/0101-2800.20150017

Cited by 4 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Renal afflictions of B19V have been reported in a variety of clinical situations with pathological lesions73 such as acute thrombotic microangiopathy48, focal segmental glomerulosclerosis or collapsing glomerulopathy4950, post-infectious glomerulonephritis51, endocapillary proliferative glomerulonephritis52 and anaemia in renal transplant recipients53. Mechanisms involved in these renal pathologies, which are associated with B19V may include causation of vasculitic changes in intra-renal small- and medium-sized blood vessels, production of cytopathic effects on glomerular epithelial or endothelial cells and massive deposition of immune complexes on subendothelial cells which is seen as electron-dense deposits on electron microscopy and all these pathological lesions result clinically in impaired immune responses, deficient production of erythropoietin besides decrease in erythrocyte survival475152.…”

Section: Multiorgan Afflictions By Human Parvovirus B19 (B19v) and Itmentioning

confidence: 99%

Clinical impact & pathogenic mechanisms of human parvovirus B19: A multiorgan disease inflictor incognito

Kishore

2018

Indian J Med Res

View full text Add to dashboard Cite

Human parvovirus B19 (B19V) causes myriads of clinical diseases; however, owing to lack of awareness and undetermined clinical impact, it has failed to become a virus pathogen of global concern. Cryptically, B19V causes significant morbidity and mortality. Half of the world population and 60 per cent of Indians are known to be serologically naive and are at risk of acquiring B19V infections. Cumulatively, our data showed 21.3 per cent B19V-infected patients with juvenile chronic arthropathy, recurrent abortions, multi-transfused thalassaemia and leukaemia. In addition, B19V-infected cases that ended fatally included patients with pure red cell aplasia, fulminant hepatitis and haemophagocytic syndrome. Novel clinical associations of B19V observed were amegakaryocytic thrombocytopaenia, myositis and non-occlusive ischaemic gangrene of bowel. B19V possesses multiple receptors which are distributed widely in human tissues. Vascular endothelial cell infection by B19V causes endothelialitis and vasculitic injuries besides antibody-dependent enhancement which empowered B19V to cause multiorgan diseases. Owing to lack of suitable animal model for B19V, true causal role remains to be determined, but numerous reports on B19V infections substantiate a causal role in multiorgan diseases. Hence, B19V infections need to be recognized, investigated and treated besides making efforts on vaccine developments.

show abstract

Section: Multiorgan Afflictions By Human Parvovirus B19 (B19v) and Itmentioning

confidence: 99%

Clinical impact & pathogenic mechanisms of human parvovirus B19: A multiorgan disease inflictor incognito

Kishore

2018

Indian J Med Res

View full text Add to dashboard Cite

show abstract

“…Parvovirus B19 has been associated with CG for over 15 years, with several case reports demonstrating temporal relationship between infection and CG in both native and transplanted kidneys, but without definitive evidence of causality or explanation of its pathogenic role [8, 19, 20]. Parvoviral DNA was detected in archived kidney biopsies with a diagnosis of non-HIV related CG significantly more often than in biopsies of other kidney lesions [7, 8].…”

Section: Introductionmentioning

confidence: 99%

Collapsing glomerulopathy in a young woman with APOL1 risk alleles following acute parvovirus B19 infection: a case report investigation

et al. 2016

View full text Add to dashboard Cite

BackgroundCollapsing Glomerulopathy (CG), also known as the collapsing variant of Focal Segmental Glomerulosclerosis (FSGS), is distinct in both its clinical severity and its pathophysiologic characteristics from other forms of FSGS. This lesion occurs disproportionally in patients carrying two APOL1 risk alleles, and is the classic histologic lesion resulting from Human Immunodeficiency Virus (HIV) infection of podocytes. Other viral infections, including parvovirus B19, and drugs such as interferon that perturb the immune system, have also been associated with CG. Despite significant advances, explaining such genetic and immune/infectious associations with causative mechanisms and supporting evidence has proven challenging.Case presentationWe report the case of a healthy (HIV-negative) pregnant 36 year-old Caribbean-American woman who presented with nephrotic syndrome and fetal demise in the setting of acute parvovirus B19 infection. A series of three renal biopsies and rapid clinical course showed progression from significant podocyte injury with mild light microscopy findings to classic viral-associated CG to ESRD in less than 3 months. Genetic analysis revealed two APOL1 G1 risk alleles.ConclusionsThis is the first published case report of CG in the setting of acute parvovirus infection in a patient with two APOL1 risk allelles, and parvoviral proteins identified in renal epithelium on kidney biopsy. These findings support the causative role of parvovirus B19 infection in the development of CG on the background of APOL1 genetic risk.Electronic supplementary materialThe online version of this article (doi:10.1186/s12882-016-0330-7) contains supplementary material, which is available to authorized users.

show abstract

“…Cytomegalovirus infection is associated with immunosuppression, but it can also occur in immunocompetent patients and progress to CG, even in the acute phase of the disease. Specific treatment is associated with several benefits for prognosis in this population (37,(39)(40)(41).…”

Section: Etiologiesmentioning

confidence: 99%

Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium

et al. 2022

View full text Add to dashboard Cite

Collapsing glomerulopathy (CG) is a clinicopathologic entity characterized by segmentar or global collapse of the glomerulus and hypertrophy and hyperplasia of podocytes. The Columbia classification of 2004 classified CG as a histological subtype of focal segmental glomerulosclerosis (FSGS). A growing number of studies have demonstrated a high prevalence of CG in many countries, especially among populations with a higher proportion of people with African descent. The present study is a narrative review of articles extracted from PubMed, Medline, and Scielo databases from September 1, 2020 to December 31, 2021. We have focused on populational studies (specially cross-sectional and cohort articles). CG is defined as a podocytopathy with a distinct pathogenesis characterized by strong podocyte proliferative activity. The most significant risk factors for CG include APOL1 gene mutations and infections with human immunodeficiency virus and severe acute respiratory syndrome coronavirus 2. CG typically presents with more severe symptoms and greater renal damage. The prognosis is notably worse than that of other FSGS subtypes.

show abstract

Collapsing variant of focal segmental glomerulosclerosis by parvovirus B19: Case report

Cited by 4 publications

References 16 publications

Clinical impact & pathogenic mechanisms of human parvovirus B19: A multiorgan disease inflictor incognito

Clinical impact & pathogenic mechanisms of human parvovirus B19: A multiorgan disease inflictor incognito

Collapsing glomerulopathy in a young woman with APOL1 risk alleles following acute parvovirus B19 infection: a case report investigation

Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium

Contact Info

Product

Resources

About