Effects of grape powder supplementation on inflammatory and antioxidant markers in hemodialysis patients: A randomized double-blind study

Janiques, Alessandra Grau de Paula Ramos; Leal, Viviane de Oliveira; Stockler‐Pinto, Milena Barcza; Moreira, Nara Xavier; Mafra, Denise

doi:10.5935/0101-2800.20140071

Cited by 26 publications

(37 citation statements)

References 18 publications

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“…Red grape seed extract, which contains antioxidant oligomeric proanthocyanidins, has been revealed to increase serum paraoxonase (PON) activity. Paraoxonase is an enzyme that protects against lipid oxidation in patients with mild to moderate hyperlipidemia [146] and in hemodialysis patients [147]. The red wine extract of onion, in particular, suppressed both the total cholesterol and LDL cholesterol levels, and also modulated inflammatory markers, such as factor VII [148].…”

Section: Cardiovascular Riskmentioning

confidence: 99%

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

Azzini²,

et al. 2020

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Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hundreds of biologically active constituents are present in each whole plant matrix, providing promissory bioactive effects for human beings. Indeed, the worldwide population has devoted increased attention and preference for the use of medicinal plants for healthy aging and longevity promotion. In fact, plant-derived bioactives present a broad spectrum of biological effects, and their antioxidant, anti-inflammatory, and, more recently, anti-aging effects, are considered to be a hot topic among the medical and scientific communities. Nonetheless, despite the numerous biological effects, it should not be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview of plant-derived bioactives in age-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion. Finally, an eye-opening look into the overall evidence of plant compounds related to longevity is presented.

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Section: Cardiovascular Riskmentioning

confidence: 99%

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

Azzini²,

et al. 2020

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“…In fact, increased uptake of food-based antioxidants can be a promising alternative measure to reduce oxidative cell damage and stress response (Weisel et al, 2006). In HD patients, few studies (Castilla et al, 2006(Castilla et al, , 2008Sportmann et al, 2008;Alipour et al, 2012;Janiques et al, 2014) have evaluated the effects of polyphenolic-rich fruit juices on antioxidant capacity, and oxidative stress. No previous studies have been carried out to determine its effect on the levels of genetic damage in such patients.…”

Section: Introductionmentioning

confidence: 98%

Unfermented grape juice reduce genomic damage on patients undergoing hemodialysis

Corredor

Rodríguez-Ribera

Coll

et al. 2016

Food and Chemical Toxicology

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“…44 In this study, the patients receiving grape powder displayed an increase in GSH-Px activity and did not exhibit increased C-reactive protein levels, as seen in placebo group, suggesting that grape powder could play a crucial role as an antioxidant and anti-inflammatory agent in non-diabetic HD patients. 44 …”

Section: Grape and Whole-grape Products For Better Healthmentioning

confidence: 48%

“…43 In another study, Janiques et al evaluated the effects of grape powder supplementation on inflammatory and antioxidant biomarkers in nondiabetic hemodialysis (HD) patients. 44 In this study, the patients receiving grape powder displayed an increase in GSH-Px activity and did not exhibit increased C-reactive protein levels, as seen in placebo group, suggesting that grape powder could play a crucial role as an antioxidant and antiinflammatory agent in non-diabetic HD patients. 44 Herrington et al evaluated the effect of muscadine grape seed supplementation on endothelial function and cardiovascular risk factors in subjects with increased cardiovascular risk.…”

Section: Evidence From Clinical Trialsmentioning

confidence: 49%

Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Singh

Liu

Ahmad

2015

Annals of the New York Academy of Sciences

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The grape antioxidant resveratrol has been a topic of intense research for the past three decades. Resveratrol and other grape ingredients, as well as whole-grape products, have shown considerable promise in health promotion and disease management. Phytochemically, whole grape represents a natural combination of resveratrol and other phytonutrients, as it contains several catechins, anthocyanins, polyphenols, and flavonols. Thus, the whole grape products or specific combinations of grape constituents provide us with the possibility of synergistic interactions leading to improved efficacy. Recent research has suggested that whole-grape products may help in maintaining heart health and protect against aging, aging-associated diseases, neurodegeneration, and some cancers. Based on the available recent literature, the grape or whole-grape products seem to be safer choices for better health and disease prevention. However, for advanced disease conditions, individual grape ingredients (such as resveratrol) or combinations of multiple ingredients together with existing therapies appear to be better approaches. Further clinical studies are needed to understand the benefits of grapes and their products in the prevention and management of specific diseases.

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Effects of grape powder supplementation on inflammatory and antioxidant markers in hemodialysis patients: A randomized double-blind study

Abstract: The use of grape powder as phenolic source could play an important role as an antioxidant and anti-inflammatory agent in non-diabetic HD patients.

Cited by 26 publications

References 18 publications

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

Unfermented grape juice reduce genomic damage on patients undergoing hemodialysis

Resveratrol, in its natural combination in whole grape, for health promotion and disease management

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