Total body water reduction in subjects with chronic kidney disease on peritoneal dialysis is associated with a better hypertension control

Júnior, José Resende de Castro; Fernandes, Natália; Lacet, Thiago Bento de Paiva; Maia, Fábio Simplício; Bonato, Glauco Resende; Nogueira, Cristianne; Barberato, Sílvio Henrique; Paula, Rogério Baumgratz de

doi:10.5935/0101-2800.20140069

Cited by 7 publications

(8 citation statements)

References 34 publications

(34 reference statements)

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“…These alterations in total body water were concordant with changes in blood pressure in each condition. Although a cause-effect relationship could not be predicated from results presented here, other investigators have shown that reduction in total body water may improve blood pressure in hemodialysis patients [23].…”

Section: Discussioncontrasting

confidence: 51%

“…Hypertension is one of medical problems in hemodialysis patients mostly originated from fluid overload [20]. Conversely, reduction of total body water in CKD could be associated with better blood pressure control [23]. In the current study, a significant difference was observed between PJ and control conditions in the amount of total body water.…”

Section: Discussionmentioning

confidence: 44%

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Effects of pomegranate juice on cardiometabolic risk factors and biomarkers of oxidative stress and inflammation in hemodialysis patients, a crossover controlled trial

Barati‐Boldaji

Akhlaghi

Sagheb

et al. 2019

Preprint

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Background: Pomegranate has antioxidant, cardioprotective, and anti-inflammatory properties. We questioned if pomegranate juice (PJ) benefits lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Methods: The study had a crossover design. Hemodialysis patients (n=41) were divided into two groups: PJ-treated group who received 100 ml natural PJ immediately after their dialysis session three times a week and the control group who received the usual care. After 8 weeks, a 4-week washout period was established and afterwards the role of the groups was exchanged. Lipid profile, blood pressure, and oxidative and inflammatory biomarkers were measured before and after each sequence. Comparisons between the two conditions were performed by ANCOVA with adjustments for potential confounders. Results: Based on results of intention-to-treat analysis, triglycerides were decreased in PJ condition and increased in the control. Conversely, high-density lipoprotein (HDL)-cholesterol was increased in PJ and decreased in control. There was a significant between-condition difference for both triglycerides and HDL-cholesterol (P<0.001). Total and low-density lipoprotein (LDL)-cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition and caused a significant difference between two conditions (P<0.001). Total antioxidant capacity increased in PJ condition (P<0.001) and decreased in control (P<0.001). Conversely, malondialdehyde and interleukin-6 decreased in PJ (P<0.001) and increased in the control (P≤0.001). The changes of these biomarkers were significantly different between two conditions. Conclusions: In conclusion, 8-week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, HDL cholesterol, oxidative stress, and inflammation in hemodialysis patients. The trial was registered at Iranian Registry of Clinical Trials (ID number: IRCT 2016070428797N1). Keywords: Pomegranate, hemodialysis, hypertension, oxidative stress, inflammation, lipid profile.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 44%

Effects of pomegranate juice on cardiometabolic risk factors and biomarkers of oxidative stress and inflammation in hemodialysis patients, a crossover controlled trial

Barati‐Boldaji

Akhlaghi

Sagheb

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Although a cause-effect relationship could not be predicted from the results presented here, other investigations suggested that reduction in the total body water may improve blood pressure in hemodialysis patients. 25 Previous studies have not examined the effect of pomegranate or polyphenols on the total body water content of hemodialysis patients; however, the blood pressure-lowering effect of PJ has been reported in previous trials on both normotensive 26 and hypertensive individuals, 27 patients with metabolic syndrome 28 and hemodialysis patients. 19 A meta-analysis of randomized controlled trials confirmed this effect independent of duration or dose of PJ.…”

Section: Discussionmentioning

confidence: 99%

Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

et al. 2019

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BACKGROUND Pomegranate has antioxidant, cardioprotective and anti‐inflammatory properties. We designed a crossover study aimed at determining if consumption of pomegranate juice (PJ) improves lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Forty‐one hemodialysis patients were randomly assigned to one of two groups: PJ‐treated group receiving 100 mL of natural PJ immediately after their dialysis session three times a week and the control group receiving the usual care. After 8 weeks, a 4‐week washout period was established and then the role of the groups was exchanged. Lipid profile, blood pressure and oxidative and inflammatory biomarkers were measured before and after each sequence. RESULTS Based on the results of intention‐to‐treat analysis, triglycerides were decreased in PJ condition and increased in the controls. Conversely, high‐density lipoprotein cholesterol was increased in PJ and decreased in the control group. Total and low‐density lipoprotein cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition. Total antioxidant capacity increased in PJ condition (P < 0.001) and decreased in the controls (P < 0.001). Conversely, malondialdehyde and interleukin‐6 decreased in PJ (P < 0.001) and increased in the control group (P ≤ 0.001). The changes of these biomarkers were significantly different between the two conditions. CONCLUSIONS Eight‐week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, high‐density lipoprotein cholesterol, oxidative stress and inflammation in hemodialysis patients. © 2019 Society of Chemical Industry

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“…Indicative factors that constitute pathophysiological mechanisms of hypertension (12) closely related to the development of sleep disorders are: hyperactivity of the sympathetic nervous system and the renin-angiotensin system (RAS); increase in the relative endotelina1/nitric oxide; the use of recombinant erythropoietin; the presence of secondary hyperparathyroidism; and especially, the increase in extracellular volume (13)(14) .…”

Section: Introductionmentioning

confidence: 99%

The quality and characteristics of sleep of hypertensive patients

Hanus

Amboni

Rosa

et al. 2015

Rev. esc. enferm. USP

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OBJECTIVEAnalyzing the quality of sleep of hypertensive patients registered in the national registration system and monitoring of hypertensive patients.METHODSA cross-sectional study of quantitative and descriptive analyses with 280 hypertensive patients registered in the National Program of Hypertension and Diabetes of the Federal Government in the months from August to October 2011. Questionnaires were used which allowed for tracking sociodemographic data on hypertension and Pittsburgh Sleep Quality Index (PSQI).RESULTSThe prevalence of poor sleep quality among respondents (156 hypertensive patients) and high rates of using medication for sleeping (106 hypertensive patients) was observed. Other relevant data refers to the quality of sleep among hypertensive patients using sleep medication compared to those who do not use it (p≤0.01).CONCLUSIONIndividuals with high blood pressure have a negative association with sleep quality.

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Total body water reduction in subjects with chronic kidney disease on peritoneal dialysis is associated with a better hypertension control

Abstract: Reduction of the volemia of patients on peritoneal dialysis, with no signs of hypervolemia, was associated with a better blood pressure control and with a decrease of the final systolic left ventricular diameter.

Cited by 7 publications

References 34 publications

Effects of pomegranate juice on cardiometabolic risk factors and biomarkers of oxidative stress and inflammation in hemodialysis patients, a crossover controlled trial

Effects of pomegranate juice on cardiometabolic risk factors and biomarkers of oxidative stress and inflammation in hemodialysis patients, a crossover controlled trial

Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

The quality and characteristics of sleep of hypertensive patients

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