Effect of vitamin D<sub>3</sub>overdose and calcium supplementation in experimental nephrolithiasis model

Ramos, Maria Fátima de Paula; Santana, Luciane Gomes de; Rasvickas, Clara Versolato; Teixeira, Vicente de Paulo Castro; Schor, Nestor

doi:10.5935/0101-2800.20140022

Cited by 9 publications

(6 citation statements)

References 38 publications

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“…Recent meta-analyses of studies examining the effect of vitamin D on type 2 diabetes and cardiovascular disease risk factors have produced largely negative results while some studies have suggested that improvements are only observed in vitamin D-deficient individuals and only with adequate vitamin D supplementation [73]. Furthermore, the side effects of long-term vitamin D administration including the hypercalcemia and hyperphosphatemia, which could potentially lead to kidney nephrolithiasis, should be considered [74]. Although several experimental data support the hypothesis of an active involvement of oxidative stress in diabetes development, the human studies are currently insufficient to support an effectiveness of antioxidant supplementation.…”

Section: Diabetesmentioning

confidence: 99%

Antioxidants and Cardiovascular Risk Factors

Pellegrino

2016

Diseases

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Cardiovascular disease (CVD), the world’s primary cause of death and disability, represents a global health problem and involves a great public financial commitment in terms of both inability to work and pharmaceutical costs. CVD is characterized by a cluster of disorders, associated with complex interactions between multiple risk factors. The early identification of high cardiovascular risk subjects is one of the main targets of primary prevention in order to reduce the adverse impact of modifiable factors, from lifestyle changes to pharmacological treatments. The cardioprotective effect of food antioxidants is well known. Indeed, a diet rich in fruits and vegetables results in an increase in serum antioxidant capacity and a decrease in oxidative stress. In contrast, studies on antioxidant supplementation, even those that are numerically significant, have revealed no clear benefit in prevention and therapy of CVD. Both short- and long-term clinical trials have failed to consistently support cardioprotective effects of supplemental antioxidant intake. The aim of this review is to evaluate the antioxidant effects on the main cardiovascular risk factors including hypertension, dyslipidemia, diabetes.

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Section: Diabetesmentioning

confidence: 99%

Antioxidants and Cardiovascular Risk Factors

Pellegrino

2016

Diseases

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“…Ramos et al, (11) concluded that calcium plus vitamin D supplements did not increase urinary stones, but played a role as a protective factor in the development of stones. According to the current study, vitamin D supplements may reduce development of urinary stones.…”

Section: Discussionmentioning

confidence: 99%

Serum Level of Vitamin D3 and Renal Stone in Children

et al. 2016

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Background: Due to high prevalence of vitamin D insufficiency in Iranian children, researchers found a low level of vitamin D among patients with nephrolithiasis. Objectives:Since previous studies showed hyper-vitaminosis D in patients with renal stone, the current study aimed to clarify this paradox. Materials and Methods:In this cross-sectional study, 100 pediatric patients with renal stone referred to Pediatric Urology and Nephrology Clinic of Baqiyatallah Hospital in Tehran, Iran, in 2014 were selected using a simple sampling method. The serum level of vitamin D3 was measured in a laboratory and the correlation between vitamin D3 and other variables were evaluated. Results:One-hundred pediatric patients, 64% male and 36% female, with renal stone were evaluated. The serum level of vitamin D and calcium had no significant difference between male and female patients. Four patients had vitamin D deficiency, 31 patients had vitamin D insufficiency and others had sufficient levels of vitamin D. There was a direct significant correlation between the level of vitamin D and calcium serum level. Family history of renal colic did not affect the serum levels of vitamin D and calcium. The serum level of vitamin D was significantly higher in patients with bilateral renal stone compared to patients with unilateral renal stone. Conclusions:Serum levels of vitamin D in children with urinary stones were low. The level of vitamin D deficiency was significantly correlated with disease severity and serum level of calcium.

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“…34 Interestingly, a recent study on animal models of nephrolithiasis shows that vitamin D and calcium supplementation may lead to a decrease rather than increase of urinary calcium suggesting that Vitamin D deficiency could actually play a role in stone formation. 35…”

Section: Methodsmentioning

confidence: 99%

Study of Idiopathic Calcium Nephrolithiasis and Vitamin D Deficiency

P¹,

Santhosh²,

Madhavan³

2016

jebmh

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BACKGROUND Vitamin D deficiency is a worldwide health concern. It prevails in epidemic proportions all over the Indian subcontinent with a prevalence of 70%-100% in the general population. Vitamin D is important in maintaining calcium and phosphorus homeostasis, but its role in kidney stone disease and its effect on stone formation are still not clear. AIMS AND OBJECTIVES In the present study, association between levels of Vitamin D and nephrolithiasis were studied. MATERIALS AND METHODS 50 patients with nephrolithiasis were selected and were compared with 50 controls matched in terms of age and sex. 25-OH Vitamin D levels were measured in both groups. RESULTS 25-OH Vitamin D levels were low in patients with nephrolithiasis when compared to controls.

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Effect of vitamin D₃overdose and calcium supplementation in experimental nephrolithiasis model

Abstract: The administration of the V associated with Ca significantly decreased the formation of stones and caused a significant reduction in urinary calcium, suggesting a protection in the lithogenic pathophysiology.

Cited by 9 publications

References 38 publications

Antioxidants and Cardiovascular Risk Factors

Antioxidants and Cardiovascular Risk Factors

Serum Level of Vitamin D3 and Renal Stone in Children

Study of Idiopathic Calcium Nephrolithiasis and Vitamin D Deficiency

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Effect of vitamin D3overdose and calcium supplementation in experimental nephrolithiasis model

Abstract: The administration of the V associated with Ca significantly decreased the formation of stones and caused a significant reduction in urinary calcium, suggesting a protection in the lithogenic pathophysiology.

Cited by 9 publications

References 38 publications

Antioxidants and Cardiovascular Risk Factors

Antioxidants and Cardiovascular Risk Factors

Serum Level of Vitamin D3 and Renal Stone in Children

Study of Idiopathic Calcium Nephrolithiasis and Vitamin D Deficiency

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Product

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Effect of vitamin D₃overdose and calcium supplementation in experimental nephrolithiasis model