Physiology of fluid and solute transport across the peritoneal membrane

Aguirre, Anna Rita; Abensur, Hugo

doi:10.5935/0101-2800.20140013

Cited by 15 publications

(7 citation statements)

References 30 publications

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“…Together, our data indicate that while the larger aggregates are stable for extended periods of time at low salt concentrations, the larger structures disassemble at ionic concentrations found in the IP space, sodium concentrations in the IP space are similar or slightly lower than found in serum (136–145 × 10 −3 m ) . Even at the highest salt concentration measured however, CPMV‐G4 aggregates would still be too large to passively diffuse across blood vessels to enter systemic circulation from the intraperitoneal space (size limit < 100 nm) and would require disassembly or lymphatic drainage for eventual clearance .…”

Section: Resultsmentioning

confidence: 71%

Slow‐Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer

et al. 2018

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The plant viral nanoparticle cowpea mosaic virus (CPMV) is shown to be an effective immunotherapy for ovarian cancer when administered as in situ vaccine weekly, directly into the intraperitoneal (IP) space in mice with disseminated tumors. While the antitumor efficacy is promising, the required frequency of administration may pose challenges for clinical implementation. To overcome this, a slow release formulation is developed. CPMV and polyamidoamine generation 4 dendrimer form aggregates (CPMV‐G4) based on electrostatic interactions and as a function of salt concentration, allowing for tailoring of aggregate size and release of CPMV. The antitumor efficacy of a single administration of CPMV‐G4 is compared to weekly administration of soluble CPMV in a mouse model of peritoneal ovarian cancer and found to be as effective at reducing disease burden as more frequent administrations of soluble CPMV; a single injection of soluble CPMV, does not significantly slow cancer development. The ability of CPMV‐G4 to control tumor growth following a single injection is likely due to the continued presence of CPMV in the IP space leading to prolonged immune stimulation. This enhanced retention of CPMV and its antitumor efficacy demonstrates the potential for viral–dendrimer hybrids to be used for delayed release applications.

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Section: Resultsmentioning

confidence: 71%

Slow‐Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer

et al. 2018

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“…This property is provided by the peritoneal mesothelial cells (PMCs), which have the constitutive ability to produce and release surfactant-like proteoglycans and phospholipids [ 57 ]. Another basic function of the peritoneum is the filtration, as the peritoneum is a semipermeable membrane for the bidirectional passage of water and dissolved particles between the blood and the peritoneal cavity [ 60 ].…”

Section: The Peritoneal Cavity: a Brief Look At Structure And Functiomentioning

confidence: 99%

The peritoneal “soil” for a cancerous “seed”: a comprehensive review of the pathogenesis of intraperitoneal cancer metastases

Mikuła-Pietrasik

Uruski

Tykarski

et al. 2017

Cell. Mol. Life Sci.

138

128

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Various types of tumors, particularly those originating from the ovary and gastrointestinal tract, display a strong predilection for the peritoneal cavity as the site of metastasis. The intraperitoneal spread of a malignancy is orchestrated by a reciprocal interplay between invading cancer cells and resident normal peritoneal cells. In this review, we address the current state-of-art regarding colonization of the peritoneal cavity by ovarian, colorectal, pancreatic, and gastric tumors. Particular attention is paid to the pro-tumoral role of various kinds of peritoneal cells, including mesothelial cells, fibroblasts, adipocytes, macrophages, the vascular endothelium, and hospicells. Anatomo-histological considerations on the pro-metastatic environment of the peritoneal cavity are presented in the broader context of organ-specific development of distal metastases in accordance with Paget’s “seed and soil” theory of tumorigenesis. The activity of normal peritoneal cells during pivotal elements of cancer progression, i.e., adhesion, migration, invasion, proliferation, EMT, and angiogenesis, is discussed from the perspective of well-defined general knowledge on a hospitable tumor microenvironment created by the cellular elements of reactive stroma, such as cancer-associated fibroblasts and macrophages. Finally, the paper addresses the unique features of the peritoneal cavity that predispose this body compartment to be a niche for cancer metastases, presents issues that are topics of an ongoing debate, and points to areas that still require further in-depth investigations.

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“…Fluid absorption occurs directly and indirectly via the lymphatics. [4][5][6][7] An overview of the physics involved in RRT…”

Section: Fluid Absorptionmentioning

confidence: 99%

Renal replacement

Brannigan

2020

South Afr J Anaesth Analg

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There are few, if any, technological advancements in the field of medicine that have been able to transform a life-threatening condition, in this case, end-stage renal failure, from a certain and horrible death, just some 100 years ago, to a condition manageable within the confines of one’s home. This refresher course, by no means a comprehensive text on peritoneal or haemodialysis, aims to provide the reader (a pre-part one FCA candidate) with the following brief overview: * A short history of dialysis * The basic physiology of fluid and solute exchange employed in renal replacement therapy (RRT) * The physical principals of RRT * Modality

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Physiology of fluid and solute transport across the peritoneal membrane

Cited by 15 publications

References 30 publications

Slow‐Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer

Slow‐Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer

The peritoneal “soil” for a cancerous “seed”: a comprehensive review of the pathogenesis of intraperitoneal cancer metastases

Renal replacement

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