Dissociation of antihypertensive and metabolic response to losartan and spironolactone in experimental rats with metabolic sindrome

Abstract

The dissociation of the antihypertensive response to the blockades of Ang II receptors and mineralocorticoid indicates the involvement of Ang II in the pathogenesis of hypertension associated with obesity. Reduction of central obesity with Spironolactone suggests the presence of mineralocorticoid adipogenic effect.

AT1 receptor blockade alters nutritional and biometric development in obesity-resistant and obesity-prone rats submitted to a high fat diet

“…In line with previous findings (Machado et al, 2012; Sagae et al, 2013; Oliveira-Junior et al, 2014), we show that oral administration of losartan abolishes weight gain in DIO rats fed a HFD without influencing body weight in age-matched chow fed, animals. Our study, however, extends these findings to show that AT1R receptor blockade also prevents weight gain in animals fed a HFD but who were not obese (DR animals).…”

“…Blockade of AT1R by a variety of pharmacological agents have also been shown to prevent HFD induced body weight gain (Sharieh Hosseini et al, 2014) or to impair body weight gain in DIO animals (Machado et al, 2012; Miesel et al, 2012; Sagae et al, 2013; Oliveira-Junior et al, 2014). An interesting finding of the present study is that AT1R blockade had a similar effect on weight gain in the DR animals but not in age-matched chow fed controls suggesting a role for the RAS on body weight gain only in animals receiving a HFD regardless of body weight and adiposity.…”

Ganho de peso e alterações metabólicas em camundongos submetidos à dieta hiperlipídica

“…A partir desses dados foi calculado o ganho de peso semanal e o Coeficiente de Eficiência Alimentar (CEA), por meio da equação: CEA= ganho de peso (g) semanal/consumo alimentar (g) semanal 12 . Ao final das 12 semanas, foi realizado o Teste Oral de Tolerância à Glicose (TOTG) 13 . Oito horas antes do teste, os animais foram colocados em jejum.…”

Telmisartan is More Effective than Taurine in Protecting High Fat Diet Induced Obesity in Rats from Hypertension, Some Metabolic, Oxidative Stress and Vascular Complications

“…Therefore, there is increasing evidence linking the low PON-1 activity to an increased likelihood of cardiovascular diseases, so, enhancing PON-1 activity could be an important target for future pharmacological agents aimed at decreasing cardiovascular risk. In the present study, both telmisartan and taurine supplementation decreased MDA that could be explained on the bases of the direct anti-oxidant effects of either telmisartan or, taurine through scavenging hydroxyl radicals, hydrogen peroxide, singlet oxygen, superoxide radicals, and peroxyl radicals thereby preventing the free radicals-mediated lipid peroxidation [35,36]. Furthermore, because lipids are substrates for lipid peroxidation, the observed decrement in serum TAG levels in the current study could be another contributing factor to the reduced MDA levels.…”

“…Food and water were supplied ad libitum. All rats were fed a standard rat chow before beginning the study and continued to consume standard rat chow composed of (23.3% protein, 66.5% carbohydrate 10.2% fat, and 13.4 kJ/g) [36] for control group (G-I), taurine group (G-II) and telmisartan group (G-III). Following acclimatization, both G-IV, G-V and G-VI were given high-fat formulated diet 56% high-fat food (7.0% protein, 37% carbohydrate, and 56% fat, 21.8 kJ/g) and water as suggested by [13].…”