Variations in adiponectin levels in patients with chronic kidney disease: a prospective study of 12 months

Kamimura, Maria Ayako; Canziani, María Eugênia Fernandes; Sanches, Fabiana M. R.; Velludo, Claudia Modesto; Carrero, Juan Jesús; Bazanelli, Ana Paula; Draibe, Sérgio Antônio; Cuppari, Lílian

doi:10.5935/0101-2800.20120007

Cited by 14 publications

(9 citation statements)

References 33 publications

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“…Moreover, our results indicated that serum adiponectin levels were positively correlated with age, and HDL-cholesterol, but negatively correlated with weight, BMI, eGFR, triglyceride, and waist and hip circumferences ( Table 2). These findings are consistent with the previous studies in healthy, obesity, type-2 diabetes, CKD, and end-stage kidney disease subjects, showing that serum adiponectin was negatively related with BMI, weight, triglyceride, eGFR, and waist and hip circumferences [12,14,35,36] and positively related with age [37] and HDL-cholesterol [5,38].…”

Section: Discussionsupporting

confidence: 93%

“…The present study revealed, for the first time, that serum adiponectin increased in individuals with mildly decreased eGFR (G2) compared to normal (G1) in all groups; normal weight, overweight, and obesity. This was consistent with previous studies showing that serum adiponectin levels increase in CKD patients [12][13][14]. The possible explanation was that inflammatory stimuli found in CKD induce adiponectin expression in renal tubular cells to trigger a feedback response [26], leading to increases in circulating adiponectin levels.…”

Section: Discussionsupporting

confidence: 92%

“…In addition, serum adiponectin is described as an independent (inverse) risk of cardiovascular events and mortality among individuals with endstage kidney disease [11]. Inversely, reports have shown that serum adiponectin increases in chronic kidney disease (CKD) [12][13][14], especially in individuals with end-stage kidney disease [15]. When the kidney is damaged or impaired, the glomerular filtration rate (GFR) decreases, resulting in an accumulation of adiponectin in blood circulation [11].…”

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confidence: 99%

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Elevation of serum adiponectin in mildly decreased glomerular filtration rate

et al. 2018

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Background: Adiponectin secreted by adipocytes plays a key role in insulin sensitivity, anti-inflammation, and antiatherosclerosis. It is involved in several conditions including obesity, type 2 diabetes mellitus, cardiovascular disease, and chronic kidney disease (CKD). Glomerular filtration rate is monitored to indicate the kidney function and CKD progression. Objective: To assess the serum adiponectin levels in individuals with normal and mildly decreased glomerular filtration rate, analyze the association of serum adiponectin with various physical and biological parameters, and test whether serum adiponectin is the risk factor of mildly decreased glomerular filtration rate. Methods: This cross-sectional study was conducted in 172 individuals with 35-60 years of age. Serum samples were collected and divided into two groups, based on estimated glomerular filtration rate (eGFR): 90 with normal eGFR (G1, eGFR ≥90 mL/min/1.73 m 2 ) and 82 with mildly decreased eGFR (G2, eGFR = 60-89 mL/min/1.73 m 2 ). Anthropometric data were recorded. Serum adiponectin was measured by enzyme-linked immunosorbent assay. Results: Serum adiponectin levels were significantly increased in individuals with mildly decreased eGFR (G2), compared to G1 (8.23 ± 3.26 mg/mL and 6.57 ± 3.24 mg/mL, respectively; P = 0.001). Serum adiponectin was positively associated with age and high-density lipoprotein cholesterol but negatively associated with weight, body mass index, triglyceride, and waist and hip circumferences. Univariate analysis showed that serum adiponectin was significantly correlated with mildly decreased eGFR; however, when adjusting for confounding factors, there were no correlations. Furthermore, multivariate regression analysis showed that individuals at the age of 46-55 years (4.0; 95% CI: 1.9-8.3) and > 55 years (11.4; 95% CI: 3.7-35.5) were significantly correlated with mildly decreased eGFR. Conclusions: Serum adiponectin was significantly elevated in individuals with mildly decreased eGFR and may be a modulation factor, but was not an independent risk factor for mildly kidney damage. Further study is needed to clarify its potential benefits as monitoring biomarker for CKD progression.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

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confidence: 99%

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Elevation of serum adiponectin in mildly decreased glomerular filtration rate

et al. 2018

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“…The clinical parameters including blood pressure, serum creatinin, total cholesterol, LDL-C and HDL-C were not significantly different in dipping tobacco users relative to those of age matched non-dipping control group (Table 1 ). The level of adiponectin is reported to increase in nephritic and renal failure [ 30 , 31 ]. Therefore, we measured serum creatinin in order to exclude any renal dysfunction in our study groups.…”

Section: Discussionmentioning

confidence: 99%

Association of hypoadiponectemia with smokeless/dipping tobacco use in young men

et al. 2015

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BackgroundLow levels of adiponectin, an adipocytokine with anti-diabetic, antiatherogenic and cardioprotective properties, is associated with increased risk of coronary disease in young men. Previous studies have demonstrated that smokeless tobacco is linked with a reduction of plasma adiponectin levels. However, the influence of smokeless tobacco (dipping tobacco) on plasma adiponectin levels still remains unknown. This study was conducted to assess the plasma adiponectin levels in young men who were using dipping tobacco.MethodsThis was a community based study, which consisted of 186 young lean healthy males aged 20 to 35 years. Among these, 96 men were dipping tobacco users (BMI = 23.07 ± 2.68) and 90 were non-dipping tobacco users (BMI = 23.67 ± 1.46). Serum adiponectin levels were assessed by Enzyme Linked ImmunoSorbent Assay (ELISA).ResultsA statistically significant difference in the mean adiponectin level between tobacco dipper and non-dipper groups was observed (p = 0.0001). A significant difference between the two groups was also observed in baseline parameters including triglyceride and random blood sugar levels (p < 0.05). However, no significant difference was observed between the two groups in other clinical parameters.ConclusionsFindings of this study suggest that dipping tobacco use was significantly associated with low level of adiponetin in community dwelling young males. This emphasizes the importance of developing community intervention to reduce the use of dipping tobacco, which will reduce the tobacco associated disease burden in the community and will improve public health.

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“…3 A number of clinical studies have observed that adiponectin levels in serum of CRF patients significantly increased with the progression of chronic kidney disease (CKD). 4 The reduction of degradability and scavenging ability was one of the main factors for the increase of adiponectin levels. Besides, adiponectin is associated with many risk factors for metabolic disorders, such as insulin sensitivity, triglycerides, high-density lipoprotein cholesterol, obesity, microalbuminuria and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Changes of adiponectin and its receptors in rats following chronic renal failure

Bao

Fan

et al. 2013

Renal Failure

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Objective: To investigate changes of adiponectin and its receptors (Adipo R) in rats following chronic renal failure. Methods: Male SD rats were randomly divided into two groups: control group and chronic renal failure (CRF) group. The CRF group were gavaged with adenine (300 mg/kg/d) for 4 weeks and the control group with drinking water. All rats were anesthetized at 2nd or 4th week and blood and urine samples were collected for detection of renal function, 24 h urine protein and adiponectin concentration. Renal tissues were also collected for HE staining, immunohistochemistry and RT-PCR screening. Results: Compared with control group, the serum concentrations of urea and creatinine, 24 h urine protein excretion in the CRF group were significantly higher at 2nd week and further increased at 4th week (p50.05). The adiponectin levels in serum and urine in the CRF group were significantly higher than those of control group (p50.01). The renal expressions of Adipo R1 and Adipo R2 in CRF group were also significantly increased compared to control group (p50.01). The increased expressions of Adipo R1 and Adipo R2 were positively related to the adiponectin levels in serum, urine, and 24 h urine protein. Conclusion: The significant changes in expression of adiponectin and its receptors in rat CRF model could be an adaptive response that may provide the basis to understand pathological changes in chronic kidney disease.

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Variations in adiponectin levels in patients with chronic kidney disease: a prospective study of 12 months

Abstract: Age, sex, renal function and visceral fat were independently associated with adiponectin levels in nondialyzed CKD patients. However, variation in visceral fat was the only predictor of variation in adiponectin levels over 12 months.

Cited by 14 publications

References 33 publications

Elevation of serum adiponectin in mildly decreased glomerular filtration rate

Elevation of serum adiponectin in mildly decreased glomerular filtration rate

Association of hypoadiponectemia with smokeless/dipping tobacco use in young men

Changes of adiponectin and its receptors in rats following chronic renal failure

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