ASYMMETRIC SULFOXIDATION OF ALBENDAZOLE TO RICOBENDAZOLE BY FUNGI: EFFECT OF pH

Overview of the Impacts of Microbial Biotransformation Bioprocesses – A Review

“…Still in the laboratory context, in addition to the food area, this biotechnology has been explored in clinical and pharmacological issues, as a promising technique in the search for biological routes in the identification of pathogenic microorganisms in exams (SOUZA; COBERLLINI, 2019) or playing a role as a method of obtaining metabolites that may act as potential new drugs, such as, for example, in the biotransformation processes of antiasthmatic drugs (AHMAD et al, 2014), anthelmintics (BARTH et al, 2015), antidepressants (OLIVEIRA et al, 2015(OLIVEIRA et al, ) al., 2015 or compounds with antimicrobial activity (GRABARCZYK et al, 2013). This biotechnology has also been linked to genetic and biochemical issues, evaluating the alterations that secondary metabolites, dispersed in the environment, It must be mentioned that concomitant biotransformation has also been addressed at the intersection of activities in the food industry and industrial innovations.…”

“…Aspergillusniger are fungi that, through fermentation processes, can hydrolyze steroid compounds, transforming them into interesting metabolites for further studies (AHMAD et al, 2014). such as Penicillium crustosum, Aspergillus fumigatus, Nigrospora sphaerica, Papulaspora immerse, Papulaspora immera Hotson and Mucor rouxii demonstrate that microorganisms can be used as biocatalytic agents in obtaining new drugs (BARTH et al, 2015;OLIVEIRA et al, 2015). Source: Own authorship.…”

“…The processes involving microbial biotransformation demonstrate the efficiency brought about by the use of this technology, both in time and quality, as well as in environmental issues. From a chemical point of view, processes that involve numerous steps for the chemical synthesis of new compounds can be reduced in number of steps, procedures, reagents and drastic conditions when using microbial biotransformation (BARTH et al, 2015). Thus, a reduction in the amount of hazardous substances involved or even their complete elimination from the synthesis processes of new metabolites can be observed, calling biotransformation green chemistry (AHMAD et al 2014).…”

Biotechnological Methods of Sulfoxidation: Yesterday, Today, Tomorrow

“…The costs associated with the purification of enzymes also disappear. It is also extremely important that some microorganisms can simulate the metabolism of mammalian cytochrome P450 monooxygenases (CYPs) [13][14][15][16][17].…”