Physicochemical Analyses of Modified Chondroitin Sulfate Biofilms

Bunhak, Élcio José; Mendes, Elisabete Scolin; Pereira, Nehemias Curvelo; Pineda, Edgardo Alfonso Gómez; Hechenleitner, Ana Adelina Winkler; Cavalcanti, Osvaldo Albuquerque

doi:10.5935/0100-4042.20150030

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were also reported by Bunhak et al . when they studied the influence of chondroitin sulfate on films prepared from isolated ethyl cellulose.…”

Section: Resultssupporting

confidence: 90%

See 1 more Smart Citation

Influence of hyaluronic acid on the formation of isolated poly(vinyl acetate) films for oral solid coatings

Zanin

Bunhak

Santos

et al. 2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

This article presents a preformulation study of isolated poly(vinyl acetate) films with the addition of hyaluronic acid (HA). The films were prepared with the solvent evaporation method and evaluated according to macroscopic, morphologic, structural, water vapor transmission (WVT), swelling index (Si%), and thickness measurements and thermal analyses. The addition of HA resulted proportional reductions in the thickness, transparency, and flexibility and increased WVT rates and Si%. Fourier transform infrared spectra demonstrated that only physical mixing occurred, whereas the thermogravimetric analysis and differential scanning calorimetry curves indicated that the films were thermally stable because the initial decomposition temperature was above 200 °C. The electron micrographs showed modifications in the structure of the polymeric mesh after imersion of films in simulated gastric or intestinal fluids. The prepared films have potential for application in pharmaceutical modification of drug release. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44815.

show abstract

“…Similar results were also reported by Bunhak et al . when they studied the influence of chondroitin sulfate on films prepared from isolated ethyl cellulose.…”

Section: Resultssupporting

confidence: 90%

“…Therefore, they have been used extensively for the development of new therapeutic delivery systems that effectively control drug release . Over the last 4 decades, various filmogenic polymers have been evaluated for use as coatings for oral solid drug dosage forms …”

Section: Introductionmentioning

confidence: 99%

Influence of hyaluronic acid on the formation of isolated poly(vinyl acetate) films for oral solid coatings

Zanin

Bunhak

Santos

et al. 2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…For decades, natural and synthetic polymers have been used in the research and development of new polymeric materials for coating that are candidates for application in oral solid systems capable of delivering drugs only in specific regions of the gastrointestinal tract [3, 4, 5, 6, 7].…”

Section: Introductionmentioning

confidence: 99%

α-Gluco-oligosaccharide in the research and development of a polymeric material for modified drug delivery

Oliveira

Bunhak

Santos

et al. 2019

Heliyon

View full text Add to dashboard Cite

This research aimed to analyse the influence of the incorporation of α-gluco-oligosaccharide (GOS-α) in the formation of isolated films of different combinations of polymethyl by applying physicochemical analyses such as Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), thermogravimetry (TG) and scanning electron microscopy (SEM). Polymer films were prepared by evaporation associating Eudragit® RS30D with α-GOS. FTIR results confirmed the incorporation of α-GOS. The intermolecular interaction involving carbonyl and hydroxyl groups of Eudragit® with α-GOS was not detected. By TG and DSC, it was possible to detect that there were no changes in the thermal properties between the proposed combinations and the standard film. Upon SEM analysis, the appearance of pores for the association 90:10 was evidenced. Possibly, these pores act as output ports for the drug. These results sharpen the perspective of applying this material to the coating of pharmaceutical formulations of modified drug delivery.

show abstract

Physicochemical Analyses of Modified Chondroitin Sulfate Biofilms

Cited by 2 publications

References 0 publications

Influence of hyaluronic acid on the formation of isolated poly(vinyl acetate) films for oral solid coatings

Influence of hyaluronic acid on the formation of isolated poly(vinyl acetate) films for oral solid coatings

α-Gluco-oligosaccharide in the research and development of a polymeric material for modified drug delivery

Contact Info

Product

Resources

About