Interactions of Chitosan/Genipin Hydrogels During Drug Delivery: A QSPR Approach

Delgadillo-Armendariz, Nancy; Rangel-Vázquez, Norma Aurea; Márquez, Edgar; Gáscue, Blanca Rojas de

doi:10.5935/0100-4042.20140243

Cited by 11 publications

(12 citation statements)

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“…A similar effect of plasma treatment can be appreciated also on comparing the absorption spectra of GG and GG_10 (Fig. 5b), although in this case the difference between the relative intensity of the Amide III bands is less evident, most likely due to the genipin contribution to the absorption spectra36. Since the 1300–1180 cm −1 range of the infrared spectrum of collagenous material includes C-O stretching and N-H bending vibrations of Amide III, the observed increase of intensity observed on plasma treated mats supports the hypothesis of formation of H bonds among the reactive species created by plasma treatment.…”

Section: Resultssupporting

confidence: 60%

Atmospheric Pressure Non-Equilibrium Plasma as a Green Tool to Crosslink Gelatin Nanofibers

Liguori

Bigi

Colombo

et al. 2016

Sci Rep

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Electrospun gelatin nanofibers attract great interest as a natural biomaterial for cartilage and tendon repair despite their high solubility in aqueous solution, which makes them also difficult to crosslink by means of chemical agents. In this work, we explore the efficiency of non-equilibrium atmospheric pressure plasma in stabilizing gelatin nanofibers. We demonstrate that plasma represents an innovative, easy and environmentally friendly approach to successfully crosslink gelatin electrospun mats directly in the solid state. Plasma treated gelatin mats display increased structural stability and excellent retention of fibrous morphology after immersion in aqueous solution. This method can be successfully applied to induce crosslinking both in pure gelatin and genipin-containing gelatin electrospun nanofibers, the latter requiring an even shorter plasma exposure time. A complete characterization of the crosslinked nanofibres, including mechanical properties, morphological observations, stability in physiological solution and structural modifications, has been carried out in order to get insights on the occurring reactions triggered by plasma.

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Section: Resultssupporting

confidence: 60%

Atmospheric Pressure Non-Equilibrium Plasma as a Green Tool to Crosslink Gelatin Nanofibers

Liguori

Bigi

Colombo

et al. 2016

Sci Rep

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“…[56] GB shows two characteristic peaks at 3365 and 3309 cm -1 that correspond to the amide stretching bands, CH=CH band at 2929 cm -1 , C=O stretching vibration at 1713 cm -1 , C=O stretching at 1615 cm -1, C=C stretching bands at 1591 and 1519 cm -1 , symmetric and asymmetric S=O2 stretching at 1340 and 1155 cm -1 , respectively. [57,58] When compared, the spectrum of drug-loaded fibrous scaffolds samples to V3S, new peaks at 3145, 1621 and 1545 cm −1 are assigned to MET for M3S and PM3S samples and new peaks at 1741, 1509, and 1242 cm −1 belong to PHR for P3S and PM3S samples. For the V3S sample, peaks at 1149, 1023, and 894 cm −1 characterize CS and peaks at 1627, 1525 and 1234 cm -1 characterize GEL and peaks at 2945, 2866, and 1720 cm -1 characterize PCL (Figure 3a).…”

Section: Fiber Compositionmentioning

confidence: 99%

Accelerated diabetic wound healing by topical application of combination oral antidiabetic agents-loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study

Çam

Ertaş

Alenezi

et al. 2021

Materials Science and Engineering: C

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The combination of oral antidiabetic drugs, pioglitazone, metformin, and glibenclamide, which also exhibit the strongest anti-inflammatory action among oral antidiabetic drugs, were loaded into chitosan/gelatin/polycaprolactone (PCL) by electrospinning and polyvinyl pyrrolidone (PVP)/PCL composite nanofibrous scaffolds by pressurized gyration to compare the diabetic wound healing effect. The combination therapies significantly accelerated diabetic wound healing in type-1 diabetic rats and organized densely packed collagen fibers in the dermis, it also showed better regeneration of the dermis and epidermis than single drug-loaded scaffolds with less inflammatory cell infiltration and edema. The formation of the hair follicles started in 14 days only in the combination therapy and lower proinflammatory cytokine levels were observed compared to single drug-loaded treatment groups. The combination therapy increased the wettability and hydrophilicity of scaffolds, demonstrated sustained drug release over 14 days, has high tensile strength and suitable cytocompatibility on L929 (mouse fibroblast) cell and created a suitable area for the proliferation of fibroblast cells. Consequently, the application of metformin and pioglitazone-loaded chitosan/gelatin/PCL nanofibrous scaffolds to a diabetic wound area offer high bioavailability, fewer systemic side effects, and reduced frequency of dosage and amount of drug.

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“…The addition of a suitable crosslinker changes a hydrogel’s structure, while improving its mechanical properties. The inclusion of a naturally-occurring crosslinker is of interest due to its inherent biocompatibility and reduced cytotoxicity [ 3 ]. One such compound which has attracted increased research activity over recent years is genipin ( Figure 1 ), a naturally-occurring iridoid which can be extracted from the fruit of Gardenia jasminoides Ellis, an evergreen bush which is found in India, China, Japan, Vietnam, and South America [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Fluorescence Imaging in Genipin Crosslinked Chitosan–Poly(vinyl pyrrolidone) Hydrogels

Matcham

Novakovic

2016

Polymers

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Recent research has identified genipin as a promising natural crosslinking agent for biocompatible hydrogels as genipin is significantly less cytotoxic than current synthetic crosslinking agents, such as glutaraldehyde. Conveniently, fluorophores can be produced when genipin crosslinks. In this study, fluorescence intensity measurements of genipin crosslinked chitosan-poly(vinyl pyrrolidone) hydrogels have been explored as a dynamic, in situ method for tracing sol-gel transition. These pH-responsive smart materials have a future in medical applications, in particular in tissue engineering and drug delivery, where methods to follow the process in situ and in real-time are crucial for future advancement. Samples were prepared using deionised water, pH 4, and pH 10 solutions, and studied at 24 and 37 • C over a 24 h period. Both temperature and pH have been found to affect sol-gel transition in the hydrogels studied. The transition from acidic (pH 4) to basic (pH 10) solution resulted in reduced fluorescence intensity suggesting that, under more basic conditions, genipin molecules self-polymerise, reducing the number of molecules available for reaction with the amino groups of chitosan. Three-dimensional representations of the fluorescence present in a hydrogel sample have also been produced from the data, enabling the visualisation of variation in fluorescence with time at the surface of the hydrogel.

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Interactions of Chitosan/Genipin Hydrogels During Drug Delivery: A QSPR Approach

Cited by 11 publications

References 1 publication

Atmospheric Pressure Non-Equilibrium Plasma as a Green Tool to Crosslink Gelatin Nanofibers

Atmospheric Pressure Non-Equilibrium Plasma as a Green Tool to Crosslink Gelatin Nanofibers

Accelerated diabetic wound healing by topical application of combination oral antidiabetic agents-loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study

Fluorescence Imaging in Genipin Crosslinked Chitosan–Poly(vinyl pyrrolidone) Hydrogels

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