PHYTOCHEMICAL INVESTIGATION OF<i>Wissadula periplocifolia</i>(L.) C. Presl AND EVALUATION OF ITS ANTIBACTERIAL ACTIVITY

Teles, Yanna Carolina Ferreira; Gomes, Roosevelt Albuquerque; Oliveira, Micaelly da Silva; Lucena, Kaio L. de; Nascimento, José Soares do; Agra, Maria de Fátima; Igoli, John O.; Gray, Alexander I.; Souza, María de Fátima Vanderlei de

doi:10.5935/0100-4042.20140238

Cited by 10 publications

(13 citation statements)

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“…The 1 H- and 13 C-NMR indicated that the compounds are chlorophyll derivatives. When compared with the literature data, they were identified as 13 2 -hydroxyphaeophytin a ( 4 ) [26] and phaeophytin a ( 5 ) [27]. These porphyrinic compounds are derived from chlorophyll a and are widely present in the vegetable kingdom [28].…”

Section: Resultsmentioning

confidence: 99%

New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae)

et al. 2015

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Abstract:The Cactaceae family is composed by 124 genera and about 1438 species. Pilosocereus gounellei, popularly known in Brazil as xique-xique, is used in folk medicine to treat prostate inflammation, gastrointestinal and urinary diseases. The pioneering phytochemical study of P. gounellei was performed using column chromatography and HPLC, resulting in the isolation of 10 substances: pinostrobin (1), β-sitosterol (2), a mixture of sitosterol 3-O-β-D-glucopyranoside/stigmasterol 3-O-β-D-glucopyranoside (3a/3b), 13 2 -hydroxyphaeophytin a (4), phaeophytin a (5), a mixture of β-sitosterol and stigmasterol (6a/6b), kaempferol (7), quercetin (8), 7 I -ethoxy-trans-feruloyltyramine (mariannein, 9) and trans-feruloyl tyramine (10).Compound 9 is reported for the first time in the literature. The structural characterization of the compounds was performed by analyses of 1-D and 2-D NMR data. In addition, a phenolic and flavonol total content assay was carried out, and the anti-oxidant potential of P. gounellei was demonstrated.

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Section: Resultsmentioning

confidence: 99%

New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae)

et al. 2015

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“…Wissadula periplocifolia (L.) C. Presl (Malvaceae) is known in Brazil as “malva amarela” and is used to treat bee stings and as an antiseptic [20]. Previous studies have demonstrated its great antioxidant potential, thus justifying a phytochemical examination for phenolic compounds [4].…”

Section: Introductionmentioning

confidence: 99%

New Sulphated Flavonoids from Wissadula periplocifolia (L.) C. Presl (Malvaceae)

et al. 2015

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Wissadula periplocifolia (L.) C. Presl (Malvaceae) is commonly used in Brazil to treat bee stings and as an antiseptic. The antioxidant properties of its extracts have been previously demonstrated, thus justifying a phytochemical investigation for its bioactive phenolic constituents. This has yielded five new sulphated flavonoids: 8-O-sulphate isoscutellarein (yannin) (1a); 4 1 -O-methyl-7-O-sulphate isoscutellarein (beltraonin) (1b); 7-O-sulphate acacetin (wissadulin) (2a); 4 1 -O-methyl-8-O-sulphate isoscutellarein (caicoine) (2b) and 3 1 -O-methyl-8-O-sulphate hypolaetin (pedroin) (3b) along with the known flavonoids 7,4 1 -di-O-methyl-8-O-sulphate isoscutellarein (4), acacetin, apigenin, isoscutellarein, 4 1 -O-methyl isoscutellarein, 7,4 1 -di-O-methylisoscutellarein, astragalin and tiliroside. The compounds were isolated by column chromatography and identified by NMR ( 1 H, 13 C, HMQC, HMBC and COSY) and LC-HRMS. A cell based assay was carried out to evaluate the preliminary cytotoxic properties of the flavonoids against UVW glioma and PC-3M prostate cancer cells as well as non-tumour cell lines. The obtained results showed that acacetin, tiliroside, a mixture of acacetin + apigenin and the sulphated flavonoids 2a + 2b exhibited inhibitory activity against at least one of the cell lines tested. Among the tested flavonoids acacetin and tiliroside showed lower IC 50 values, presenting promising antitumor effects.

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“…3 which are characteristic of tetracyclic triterpene alcohols with di-unsaturated side chain and also a saturated skeleton [30]. The 1 H NMR data of compound 1 (Table 1), which were compared with those of the known compounds dammara-20,24-dien-3β-ol [31], dammaradienone [32] and 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic [33] showed the presence of a vinylic proton on a tri-substituted double bond at δ H 5.12 (d, J = 6.4 Hz), two proton doublets resonating at δ H 4.70 (J = 1.4 Hz) and 4.60 (J = 1.4 Hz) assignable to C-21 methylene protons and two vinylic methyl protons at δ H 1.68 (Me-26 and Me-27). The vinylic proton at δ H 5.12 was shown to allylically couple with the vinylic methyls by homonuclear decoupling experiments, thus authenticating the presence of a terminal -CH 2 -CH= C(CH 3 ) 2 group [31].…”

Section: Compoundmentioning

confidence: 99%

Chemical constituents of Ocimum kilimandscharicum Guerke acclimatized in Kakamega Forest, Kenya

Makenzi¹,

Manguro²,

Owuor³

et al. 2019

Bull. Chem. Soc. Eth.

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The genus Ocimum belongs to the Lamiaceae family and is made of almost 200 species of herbs and shrubs which have potential medicinal properties. The species are native to the tropical and temperate climate zones around the globe. Two new compounds with damarane skeleton namely 2α-hydroxy-3-oxodammara-20,24diene (1) and 2α,3β-dihydroxy dammara-20, 24-diene (2) together with apeginin7-O-neohespeiridoside (3), quercetin (4), turkesterone (5), fesitin (6), apeginin (7), chrysin (8), lupeol (9), stigmasterol (10), friedelin (11), αamyrin acetate (12) and n-octacosonoic acid (13) are reported here from the leaves of Ocimum kilimandscharicum. Their structures were established on the basis of physical and spectroscopic analyses and by comparison with the literature data. Crude extracts and isolated compounds were investigated for contact toxicity and anti-feedant activity against Sitophilus zeamais and Prostephanus truncatus.

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PHYTOCHEMICAL INVESTIGATION OFWissadula periplocifolia(L.) C. Presl AND EVALUATION OF ITS ANTIBACTERIAL ACTIVITY

Cited by 10 publications

References 0 publications

New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae)

New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae)

New Sulphated Flavonoids from Wissadula periplocifolia (L.) C. Presl (Malvaceae)

Chemical constituents of Ocimum kilimandscharicum Guerke acclimatized in Kakamega Forest, Kenya

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