HPLC-DAD BASED METHOD FOR THE QUANTIFICATION OF FLAVONOIDS IN THE HYDROETHANOLIC EXTRACT OF<i>Tonina fluviatilis</i>Aubl. (Eriocaulaceae) AND THEIR RADICAL SCAVENGING ACTIVITY

Amorim, Marcelo R. de; Rinaldo, Daniel; Amaral, Fabiano Pereira do; Vilegas, Wagner; Magenta, Mara Angelina Galvão; Vieira, Gerardo Magela; Santos, Lourdes Campaner dos

doi:10.5935/0100-4042.20140193

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…After obtaining the compounds and elucidating their structures, they were quantified in the extracts by using HPLC-DAD. The radical scavenging activity was also performed to extract and isolate compounds, showing a better result for compounds 30 and 35 [ 1 ].…”

Section: Resultsmentioning

confidence: 99%

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Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning

et al. 2022

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Eriocaulaceae is a pantropical family whose main center of biodiversity is in Brazil. In general, the family has about 1200 species, in which phytochemical and biological studies have shown a variety of structures and activities. The aim of this research is to compile the compounds isolated in the Eriocaulaceae family and carry out a computational study on their biological targets. The bibliographic research was carried out on six databases. Tables were built and organized according to the chemical class. In addition, a summary of the methods of isolating the compounds was also made. In the computational study were used ChEMBL platform, DRAGON 7.0, and the KNIME 4.4.0 software. Two hundred and twenty-two different compounds have been isolated in sixty-eight species, divided mainly into flavonoids and naphthopyranones, and minor compounds. The ligand-based virtual screening found promising molecules and molecules with multitarget potential, such as xanthones 194, 196, 200 and saponin 202, with xanthone 194 as the most promising. Several compounds with biological activities were isolated in the family, but the chemical profiles of many species are still unknown. The selected structures are a starting point for further studies to develop new antiparasitic and antiviral compounds based on natural products.

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Section: Resultsmentioning

confidence: 99%

“…Eriocaulaceae is a pantropical family, which comprises around 1200 species divided in ten genera [ 1 ]. It is easily distinguished from other families due to most of its species presenting short stems, leaves in a rosette form, and long scapes grouped in capitula [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning

et al. 2022

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“…Planifoliusin A (9) , H-10'), 9.74 (s, 1H, H-9) and 9.75 (s, 1H, H-9') were attributed to hydroxyl groups. The 13 C NMR spectrum of 9 presented 31 signals of which two peaks were assignable to the carbonyls of the lactone ring at d C 171.7 (C-1) and 168.4 (C-1') ( Table 3) and 16 signals correlated well with those of paepalantine.…”

Section: Elucidation Of Planifoliusin a (9)mentioning

confidence: 98%

“…4,5 Although Eriocaulaceae are used in the manufacture of ornamental products, literature reports studies with Eriocaulaceae species that have promising antimicrobial activity. 6,7 Other studies have previously demonstrated the importance of extract and isolated substances in the Eriocaulaceae family, mainly because they present a great biological potential, such as the already identified antioxidant activities, 8,9 cytotoxic, 10,11 antiulcerogenic, 12 antibacterial and vulvovaginal candidiasis treatment. 13,14 Thus, in search of new biological compounds we described the antimicrobial activity of ethyl acetate (EtOAc) extract of capitula from Paepalanthus planifolius and its phytochemical characterization.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Paepalanthus planifolius and its Major Components against Selected Human Pathogens

Amorim

Hilário

Sano

et al. 2017

J. Braz. Chem. Soc.

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The chemical investigation of ethyl acetate extract from Paepalanthus planifolius capitula resulted in the identification of 1H-naphtho [2,3-c],10-dihydroxy-5,7-dimethoxy-3-methyl, vioxanthin and paepalantine dimer, and also the isolation and identification of a new naphthopyranone dimer named planifoliusin A. The chemical structures of two compounds were elucidated by performing spectroscopic 1D and 2D nuclear magnetic resonance (NMR) experiments and spectrometric HRMS (high-resolution mass spectrometry) analysis. Other six naphthopyranone dimers were proposed by MS fragmentation patterns. The minimum inhibitory concentration (MIC) values for vioxanthin (7.8 µg mL

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Quantitative Evaluation of Various Preparations and Extracts of the Male Contraceptive Justicia gendarussa and Identification of a New Aminobenzyl Derivative

Mnatsakanyan

Queiroz

Marcourt

et al. 2018

PMIO

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Justicia gendarussa is a medicinal plant found in different regions of Indonesia and used in decoctions by Papuan tribes to reduce male fertility. An enriched ethanolic extract of this plant has been used in the frame of clinical trials in Indonesia to evaluate its male contraceptive activity. Previous studies have indicated that the flavonoid gendarusin A may have a role in the male contraception properties of this plant. In addition, the level of aminobenzyl derivatives was lowered as a safety precaution. In order to obtain a comprehensive chemical profile of the methanolic plant extract, it was analysed by HPLC-PDA-ESI-MS and UHPLC-TOF-HRMS. The same method was also applied to profile extracts of the same plant material from different Indonesian regions, a water decoction used traditionally, and the enriched extract used in clinical trials. This allowed for the dereplication of all previously known flavonoids and newly reported amides, and permitted highlighting the presence of the potentially new aminobenzyl derivative. Targeted isolation of this new amide was performed using medium-pressure liquid chromatography. NMR and HRMS allowed for the establishment of the identity of the novel compound. The same procedure was used to obtain pure standards for quantitative studies. Quantitation of the major compounds was performed for different extracts using HPLC-UV. Significant differences were observed between the samples. Although gendarusin A was the main compound in all samples, it occurred in different amounts in the batches of dried material obtained from different Indonesian regions. The enriched extract contained mainly gendarusin A, as did the traditional decoction, but the level of the aminobenzyl derivatives was significantly lower.

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HPLC-DAD BASED METHOD FOR THE QUANTIFICATION OF FLAVONOIDS IN THE HYDROETHANOLIC EXTRACT OFTonina fluviatilisAubl. (Eriocaulaceae) AND THEIR RADICAL SCAVENGING ACTIVITY

Cited by 5 publications

References 3 publications

Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning

Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning

Antimicrobial Activity of Paepalanthus planifolius and its Major Components against Selected Human Pathogens

Quantitative Evaluation of Various Preparations and Extracts of the Male Contraceptive Justicia gendarussa and Identification of a New Aminobenzyl Derivative

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