TERPENOIDS AND COUMARINS FROM<i>Jatropha ribifolia</i>(Pohl) Baill

Batista, Pedro Henrique Jataí; Andrade, José Roberto M. de; Matos, Taynara Simão; Sousa, Thiciana da Silva; Pinto, Francisco das Chagas L.; Silveira, Edilberto R.; Loiola, Maria Iracema Bezerra; Pessoa, Otília Deusdênia Loiola

doi:10.5935/0100-4042.20140172

Cited by 5 publications

(3 citation statements)

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“…1993 ; Batista et al. 2014 ), although, recent studies have demonstrated results in which chemical shifts for carbons C-3 and C-5 of this compound were inverted (Fernandes et al. 2013 ; Sahidin et al.…”

Section: Resultsmentioning

confidence: 99%

Antinociceptive and anti-inflammatory activities of the Jatropha isabellei dichloromethane fraction and isolation and quantitative determination of jatrophone by UFLC-DAD

Frohlich

Stein

Silva

et al. 2017

Pharmaceutical Biology

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Context:Jatropha isabellei Müll. Arg. (Euphorbiaceae) has been used in the traditional medicine to treat arthritis.Objective: To evaluate the anti-inflammatory and antinociceptive activities of the dichloromethane fraction (DFJi) from underground parts of J. isabellei, and to develop an analytical method to quantify the diterpene jatrophone.Materials and methods: Anti-inflammatory and antinociceptive activities of the DFji were determined by an acute arthritis model through assessment of the paw elevation time (PET) and articular diameter (AD) of Wistar rats treated orally (50, 100 or 200 mg/kg in a single-dose), and intravenously (0.1, 1, 10, 25 or 50 mg/kg in a bolus administration). The isolation of jatrophone from the DFji was carried out and confirmed by spectroscopic techniques. A UFLC-DAD method was developed and validated.Results: When orally administered, the highest dose (200 mg/kg) of DFJi was able to significantly reduce the PET to 24.8 ± 1.4 s (p < 0.01), when compared with the control group (33.7 ± 1.8 s). The administration of the intravenous dose of 10 mg/kg reduced the PET to 14.8 ± 0.3 s (p < 0.001). The oral and intravenous administration of the DFJi at dose of 200 and 10 mg/kg significantly prevented the formation of edema, reducing the AD in 25.3% and 32.5% (p < 0.01), respectively. The UFLC-DAD method allowed the quantification of jatrophone, which was found to be around 90 μg/mg of fraction.Discussion and conclusion: The DFJi displayed antinociceptive and antiedematogenic activities, representing a promising plant product for the arthritis treatment.

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Section: Resultsmentioning

confidence: 99%

Antinociceptive and anti-inflammatory activities of the Jatropha isabellei dichloromethane fraction and isolation and quantitative determination of jatrophone by UFLC-DAD

Frohlich

Stein

Silva

et al. 2017

Pharmaceutical Biology

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“…Species of the genus Jatropha have been used in the treatment of diabetes [ 1 ], and malaria [ 2 ], as well as for their anti-plasmodial [ 3 ], anti-leishmanial, anti-bacterial, anti-microbial [ 4 ], anti-molluscicidal [ 5 ], anti-carcinogenic, anti-proliferative [ 6 ], gastroprotective [ 7 ], and anti-inflammatory [ 8 ] activities. Of the 21 species of the Jatropha genus studied, 175 known bioactive compounds have been found, such as cyclic peptides, lignans [ 9 ], flavonoids [ 1 ], coumarins [ 10 ], alkaloids [ 11 ], monoterpenes [ 7 ], sesquiterpenes [ 3 ], diterpenes [ 3 ], and triterpenes [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Characterization and In Vitro Anti-Inflammatory Evaluation in RAW 264.7 Cells of Jatropha cordata Bark Extracts

Jiménez-Nevárez

Angulo-Escalante

Montes‐Ávila

et al. 2023

Plants

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The inflammatory process, although beneficial, can produce tissue damage and systemic damage when uncontrolled. Effective therapeutic alternatives with little or no side effects are of great therapeutic interest. This study aimed to determine the phytochemical composition of bark extracts from J. cordata, an endemic plant from México, and evaluate their in vitro anti-inflammatory activity. Hexane, ethyl acetate, and methanol extracts were characterized by qualitative phytochemical tests, and their bioactive groups were identified by 1H NMR and gas chromatography coupled to mass spectrometry (GC–MS). The extract’s anti-inflammatory activity was evaluated as nitric oxide (NO) production and their cytotoxicity by an MTS cell proliferation assay in lipopolysaccharide (LPS)-activated RAW 264.7 cells at concentrations of 1–100 μg/mL. The hexane extract contained fatty acids, fatty esters, phytosterols, alkanes, vitamin E, and terpenoids; the ethyl acetate extract showed fatty acids, fatty esters, aromatic aldehyde, phytosterols, vitamin E, and terpenoids, while the methanolic extract showed fatty esters, fatty acid, aromatics aldehydes, and alcohol. The ethyl acetate extract showed the highest inhibition of NO production, followed by the methanolic extract and the hexane extract, without affecting the viability of RAW 264.7 macrophage cells. The results suggest that J. cordata extracts are a potential source of bioactive compounds with anti-inflammatory potential.

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“…In this sense, in folklore medicine the leaves, stems, roots, and seeds of different species from the genus Jatropha have gained popularity as anti-inflammatory and antioxidant agents. − Several studies have focused on identifying compounds in the genus Jatropha , including phenolics such as gadain, gossypidien, isogadain, isovitexin, vitexin, 2,3-bis(hydroxymethyl)-6,7-methylenedioxy-1-(3′4′-dimethoxyphenyl)naphthalene dihydroprasantalin, apigenin 7- O -neohespredoside, ferulic acid, quercetin, vicinin-II, isoorientin, and luteolin, among others . In addition, there are reports of the presence of lipophilic compounds, including terpenoids such as jatrophone, fatty acids such as linoleic and oleic acid, sterols such as lanosterol, β-sitosterol, and ζ-sitosterol, and others. In Mexico there are endemic nontoxic species of Jatropha , one of them being Jatropha platyphylla; this species grows along the Pacific coast, from the state of Sinaloa to Michoacán, where it is traditionally consumed by the local people as roasted seeds or pulp marmalades.…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Flavonoids and Lipophilic Compounds from Jatropha platyphylla on the Suppression of Lipopolysaccharide (LPS)-Induced Inflammation in Macrophage Cells

Ambriz-Pérez

Bang²,

Nair³

et al. 2016

J. Agric. Food Chem.

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Seventeen polyphenols (e.g, apigenin, genistein, and luteolin glycosides) and 11 lipophilic compounds (e.g., fatty acids, sterols, and terpenes) were detected by LC-MS/MS-ESI and GC-MS, respectively, in Jatropha platyphylla. Extracts from pulp, kernel, and leaves and fractions were studied to know their effect on some pro-inflammatory mediators. Phenolic and lipophilic extracts showed significant inhibitory effects on ROS and NO production while not affecting mitochondrial activity or superoxide generation rate in lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophage cells. In addition, NO production was also diminished by lipophilic leaf fractions F1 and F2 with the latter fraction showing a greater effect and composed mainly of sterols and terpene. Furthermore, total extracts showed nonselective inhibitions against cyclooxygenase COX-1 and COX-2 activities. All together, these results suggest that J. platyphylla extracts have potential in treating inflammatory diseases and their activity is mediated by flavonoids and lipophilic compounds.

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TERPENOIDS AND COUMARINS FROMJatropha ribifolia(Pohl) Baill

Cited by 5 publications

References 0 publications

Antinociceptive and anti-inflammatory activities of the Jatropha isabellei dichloromethane fraction and isolation and quantitative determination of jatrophone by UFLC-DAD

Antinociceptive and anti-inflammatory activities of the Jatropha isabellei dichloromethane fraction and isolation and quantitative determination of jatrophone by UFLC-DAD

Phytochemical Characterization and In Vitro Anti-Inflammatory Evaluation in RAW 264.7 Cells of Jatropha cordata Bark Extracts

Protective Role of Flavonoids and Lipophilic Compounds from Jatropha platyphylla on the Suppression of Lipopolysaccharide (LPS)-Induced Inflammation in Macrophage Cells

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