Analysis quantitative and qualitative of the tear film in patients undergoing PRK and LASIK with femtosecond

Leite, Rubens Amorim; Nosé, Ricardo Menon; Daga, Fábio B.; Lui, Tatiana Adarli Fioravanti; Lui, Giovana Arlene Fioravanti; Lui-Netto, Adamo

doi:10.5935/0034-7280.20140059

Cited by 1 publication

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“…Diagnostic tests for KCS should combine high precision, good sensitivity, and practicality (12)(13)(14)(15)(16) . Therefore, in humans, the need to develop a faster, less invasive, and easier-to-use method for the assessment of tear volume has led researchers to develop a simple and innovative method called the strip meniscometry test (SMT) (16)(17)(18) .…”

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confidence: 99%

“…2022 -Ahead of Print STT-1 has been used in both humans and animals as the gold standard for the quantitative diagnosis of KCS by measuring the volume of the aqueous portion of the tear film. However, the test requires patients to endure the discomfort caused by inserting the paper strip in the eye, which characterizes the technique as invasive (12)(13)(14)(15) . The SMT is a noninvasive diagnostic tool for KCS that can be performed in 5 sec without inducing the lacrimation reflex.…”

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confidence: 99%

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Comparison of strip meniscometry and Schirmer tear test results and tear film breakup time between healthy dogs and dogs with dry eye disease

Nascimento¹,

Passareli²,

Zulim³

et al. 2023

ABO

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To compare strip meniscometry and Schirmer tear test 1 results and tear film breakup time between dogs with normal eyes and dogs diagnosed with keratoconjunctivitis sicca. Methods: One-hundred fifty-six eyes of 78 dogs, 88 normal eyes, and 68 eyes diagnosed with keratoconjunctivitis sicca were included in the study. The tests were performed in the following sequence: Schirmer tear test 1 was used to allocate the dogs to the normal or keratoconjunctivitis sicca group, followed by the strip meniscometry test and tear film breakup time measurement. Results: The results (mean ± standard deviation) of the tests in the normal group were as follows: Schirmer tear test 1, 22.75 ± 3.88 mm/min; strip meniscometry test, 10.01 ± 2.35 mm/5 sec; and tear film breakup time, 25.82 ± 5.47 sec. In the keratoconjunctivitis sicca group, the results were as follows: Schirmer tear test 1, 6.10 ± 4.44 mm/min; strip meniscometry test, 3.03 ± 2.62 mm/5 sec; and tear film breakup time, 10.78 ± 4.23 sec. The Spearman correlation coefficient in the keratoconjunctivitis sicca group was very high, with a significant difference between the strip meniscometry test and Schirmer tear test 1 (r=0.848, p<0.001), and moderate and significant between the strip meniscometry test and tear film breakup time (r=0.773, p<0.001). The cutoff for the strip meniscometry test for keratoconjunctivitis sicca was 7.0 mm/5 sec. Keratoconjunctivitis sicca was suspected when the values were <10 mm/5 sec. Conclusions: This study provided strip meniscometry test values from dogs with normal eyes and eyes with keratoconjunctivitis sicca, with high sensitivity and specificity compared with those of the Schirmer tear test 1. In the future, the strip meniscometry test may be another important quantitative test and could complement the gold standard Schirmer tear test for the diagnosis of keratoconjunctivitis sicca in dogs, an excellent animal model for the study of the disease.

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