Carboplatin-loaded surface modified-PLGA nanoparticles confer sustained inhibitory effect against retinoblastoma cell in vitro

Zhuang, Hua; Xu, Yanan; Zheng, Honghua; Huan, Yu-Rong; Zheng, Ning-Xuan; Lin, Lin; Zhang, Wu-Zhen; Xu, Wei

doi:10.5935/0004-2749.20220075

Cited by 4 publications

(4 citation statements)

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“…31 Carboplatin-loaded PLGA and SA-PLGA were studied to investigate their antiproliferative effect on retinoblastoma cells. 32 Following 7 days after treatment in vitro, the authors observed significant intracellular uptake when compared to the control group. The study revealed an improved growth inhibitory effect when compared to native carboplatin.…”

Section: Effective Treatment Approachmentioning

confidence: 92%

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An Overview of Nanoparticles for Treatment of Retinoblastoma: Disease Characteristics and Experimental Approaches

Patel

Conte

Luo

et al. 2022

MRAJ

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Retinoblastoma is the most common type of eye cancer in infants and children. Probability of saving vision and survival depends upon two main factors: progression of the disease from unilateral to bilateral and severity of the disease. In order to effectively treat retinoblastoma and retain vision, it is crucial to focus treatment options on reducing toxicity and nonspecific targeting while enhancing drug delivery, cellular uptake, and accumulation of chemotherapeutic agents to their specific target sites. Rapid elimination from blood circulation is the greatest obstacle that conventional chemotherapeutic agents face on journey to their target sites. Target specific nanoparticles have proven to be a useful tool in efforts to overcome challenges typically encountered by targeting strategies. Development of nanoparticles loaded with chemotherapeutic agents can allow for more selective tumor targeting, extended drug circulation times, and reduced drug-associated toxicity. Nanoparticles can significantly improve the treatment efficacy in retinoblastoma. The purpose of this review is to discuss the important characteristics and differences of nano delivery systems used against cellular and in vivo models of retinoblastoma, particularly as they relate to the popular Y79 retinoblastoma cell line.

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Section: Effective Treatment Approachmentioning

confidence: 92%

“…The study revealed an improved growth inhibitory effect when compared to native carboplatin. 32 Nanoparticles offer interesting possible solutions for the treatment for retinoblastoma. For example, the anticancer drug nutlin-3a, activates the tumor suppressor gene p53.…”

Section: Effective Treatment Approachmentioning

confidence: 99%

An Overview of Nanoparticles for Treatment of Retinoblastoma: Disease Characteristics and Experimental Approaches

Patel

Conte

Luo

et al. 2022

MRAJ

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“…Advantageously, in vitro exposure to these nanoparticles in HepG2 and Caco-2, colon and hepatic cells, showed the absence of systemic toxicity, highlighting their potential as oral dosage forms [52]. Zhuang et al (2021) exposed carboplatin-loaded, sodium alginate (SA) surface-modified PLGA NPs to Y79 cells in vitro, which highlighted the benefits of SA when it comes to cellular uptake and the pace of drug delivery. The PLGA NPs were round, with a mean size of 253.94 ± 66.53 nm and a Zeta potential of around −43.1 ± 8.1 mV.…”

Section: Organic Nanoparticles 421 Polymeric Nanoparticlesmentioning

confidence: 99%

“…Analysis of the inhibitory effect on Y79 cell viability showed that PLGA NPs with SA exhibited higher effects at all concentrations and times compared to SA-absent PLGA NPs. Their future incentives include in vivo topical administration of their engineered NP as a treatment comparable to intravitreal drug delivery and its side effects [53]. Based on these studies, there exists an endless possibility of combinations of types of polymers, drugs, and surface modification.…”

Section: Organic Nanoparticles 421 Polymeric Nanoparticlesmentioning

confidence: 99%

Advancements in Nanosystems for Ocular Drug Delivery: A Focus on Pediatric Retinoblastoma

Wu,

Wang,

Anderson

et al. 2024

Molecules

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The eye’s complex anatomical structures present formidable barriers to effective drug delivery across a range of ocular diseases, from anterior to posterior segment pathologies. Emerging as a promising solution to these challenges, nanotechnology-based platforms—including but not limited to liposomes, dendrimers, and micelles—have shown the potential to revolutionize ophthalmic therapeutics. These nanocarriers enhance drug bioavailability, increase residence time in targeted ocular tissues, and offer precise, localized delivery, minimizing systemic side effects. Focusing on pediatric ophthalmology, particularly on retinoblastoma, this review delves into the recent advancements in functionalized nanosystems for drug delivery. Covering the literature from 2017 to 2023, it comprehensively examines these nanocarriers’ potential impact on transforming the treatment landscape for retinoblastoma. The review highlights the critical role of these platforms in overcoming the unique pediatric eye barriers, thus enhancing treatment efficacy. It underscores the necessity for ongoing research to realize the full clinical potential of these innovative drug delivery systems in pediatric ophthalmology.

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Weibull β value for the discernment of drug release mechanism of PLGA particles

Martín-Camacho

Rodríguez-Barajas

Sánchez-Burgos

et al. 2023

International Journal of Pharmaceutics

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Carboplatin-loaded surface modified-PLGA nanoparticles confer sustained inhibitory effect against retinoblastoma cell in vitro

Cited by 4 publications

References 0 publications

An Overview of Nanoparticles for Treatment of Retinoblastoma: Disease Characteristics and Experimental Approaches

An Overview of Nanoparticles for Treatment of Retinoblastoma: Disease Characteristics and Experimental Approaches

Advancements in Nanosystems for Ocular Drug Delivery: A Focus on Pediatric Retinoblastoma

Weibull β value for the discernment of drug release mechanism of PLGA particles

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