has lipid-lowering effects 12 19 . Other reports have, however, demonstrated no lipid-lowering effect for policosanol 20 23 . Direct comparisons of these divergent findings have been limited by differences in regional dietary patterns and by the unknown variability of the composition of the policosanol products that were tested 24 . Being lipophilic, policosanol was reported to have bioavailability between 5 to 12 25 . In this regard, we have developed and characterized the policosanol nanoemulsion from rice bran wax, which we found to be very stable 26 . In the present study, we focused on the effects of rice bran wax policosanol POL and its nanoemulsion NPOL on plasma homocysteine, heart and liver histology, and regulation of hepatic PPARG mRNA in hyperlipidemic Sprague Dawley rats.