Artificial cornea transplantation and visual rehabilitation: an integrative review

Abstract

Due to the development of complications and the biocompatibility and scarcity of transplant donor tissues, artificial corneas, which can be used for the rehabilitation of optical functions, have been developed. The current study aimed to analyze the visual rehabilitation effects of the Boston type I keratoprosthesis, Boston type II keratoprosthesis, Aurolab keratoprosthesis, osteo-odonto-keratoprosthesis, and tibial bone keratoprosthesis. Results showed that the Boston type I keratoprosthesis was the most effective for visual rehabilitation in patients with moist ocular surfaces. The Aurolab keratoprosthesis had a lower efficacy for visual rehabilitation. Nevertheless, it is still a viable option for individuals in economically restricted countries. In patients with dry eyes, the Boston type II keratoprosthesis was associated with the best visual rehabilitation. However, the final visual acuity of patients who received osteo-odonto-keratoprosthesis and tibial bone keratoprosthesis implantation was not evaluated as the necessary information was not available.

A global bibliometric and visualized analysis in the status and trends of corneal tissue engineering research from 1991 to 2021

“…At least 1 billion of these patients are visually impaired, 4.2 million of which are owing to unresolved corneal opacity. 3 …”

“…At least 1 billion of these patients are visually impaired, 4.2 million of which are owing to unresolved corneal opacity. 3 At present, keratoplasty was the only approved therapeutic strategy for corneal injury. 2,4 In 2012, it is estimated that 12.7 million people around the world are waiting for corneal transplants.…”