Frequency of conjunctival epithelial dysplasia in patients with pterygium

Lomelí-Linares, Daniel; García-Salgado, Lissete; Riancho-Sánchez, Gabriela; López-Star, Ellery; Lansingh, Van Charles; Corredor-Casas, Sonia

doi:10.5935/0004-2749.20200053

Cited by 4 publications

(1 citation statement)

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“…The thin line and overlapping characteristics to describe cellular reactions (i.e., atypia), cellular adaptations (i.e., hyperplasia and metaplasia) and preneoplastic lesions (i.e., dysplasia) complicates the molecular and histological classification of pterygium as a benign or potentially preneoplastic lesion. Based on the characteristics of dysplasia, numerous reports of unsuspected OSSN in patients with pterygium have appeared in the USA (Florida, 1% and 4.2%) [ 122 , 123 ], Thailand (1.8%) [ 124 ], Australia (New South Wales, 5%, mild to severe dysplasia [ 4 ]; Queensland, 9.8% [ 125 ]) and Mexico (11.29%), among others [ 126 ]. The changes observed in impression cytology that correspond to dysplasia are also of the utmost importance, as impression cytology removes the superficial layer of the ocular surface epithelia [ 127 ].…”

Section: Dysplasia and Ocular Surface Squamous Neoplasiamentioning

confidence: 99%

Pterygium—The Good, the Bad, and the Ugly

Acker

Bogerd

Haagdorens

et al. 2021

Cells

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Pterygium is a multifaceted pathology that displays apparent conflicting characteristics: benign (e.g., self-limiting and superficial), bad (e.g., proliferative and potentially recurrent) and ugly (e.g., signs of preneoplastic transformation). The natural successive question is: why are we lacking reports showing that pterygium lesions become life-threatening through metastasis, especially since pterygium has considerable similarities with UV-related malignancies on the molecular level? In this review, we consider how our pathophysiological understanding of the benign pterygium pathology overlaps with ocular surface squamous neoplasia and skin cancer. The three UV-related disorders share the same initial insult (i.e., UV radiation) and responsive repair mechanisms to the ensuing (in)direct DNA damage. Their downstream apoptotic regulators and other cellular adaptations are remarkably alike. However, a complicating factor in understanding the fine line between the self-limiting nature of pterygium and the malignant transformation in other UV-related diseases is the prominent ambiguity in the pathological evaluation of pterygium biopsies. Features of preneoplastic transformation (i.e., dysplasia) are used to define normal cellular reactions (i.e., atypia and metaplasia) and vice versa. A uniform grading system could help in unraveling the true nature of this ancient disease and potentially help in identifying the earliest intervention point possible regarding the cellular switch that drives a cell’s fate towards cancer.

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