Relationships between corneal biomechanics and the structural and functional
            parameters of glaucoma damage

Hocaoğlu, Mümin; Kara, Caner; Şen, Emine; Öztürk, Faruk

doi:10.5935/0004-2749.20200019

Cited by 7 publications

(6 citation statements)

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“…As shown in other publications, in our study, both CH and CRF values were lower in POAG patients than in OH patients and in NE [ 10 , 24 , 25 , 30 , 31 , 33 , 36 – 40 ], and a study that included both eyes of POAG patients revealed that the most affected eye had a lower CH compared to the other eye [ 16 ]. Moreover, studies revealed that a high CH has a protective role in OH patients [ 38 ].…”

Section: Discussionsupporting

confidence: 87%

“…Risk factors that need to be taken into consideration in every glaucoma suspect are already known, but recent studies show that, in addition to IOP, genetics, and CCT, CBP might be a new risk factor independent of IOP [ 2 – 6 , 8 , 9 , 24 – 29 ]. Park et al proved that in normal-tension glaucoma (NTG), low CH was associated with a thin pRNFL and a large cup/disc ratio, regardless of the IOP and CCT [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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The Relationship Between Corneal Hysteresis and Retinal Ganglion Cells – A Step Forward in Early Glaucoma Diagnosis

et al. 2020

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Background Glaucoma is a major cause of irreversible visual field (VF) loss across the world. Many studies have assessed the accuracy of glaucoma diagnostic tests for a more precise diagnosis to quickly identify patients with higher risk of progression. Material/Methods We conducted a study that included 214 eyes divided into 3 groups: 79 eyes from patients diagnosed with primary open-angle glaucoma (POAG), 68 eyes from patients diagnosed with ocular hypertension (OH), and 67 eyes from normal individuals (normal eyes, NE). All patients included in the study received a complete checkup. Results In POAG patients, means of central corneal thickness (CCT), corneal hysteresis (CH), corneal resistance factor (CRF), mean defect (MD), visual field index (VFI), peripapillary retinal nerve fiber layer (pRNFL), and ganglion cell complex (GCC) are lower than in OH patients, and in NE are higher than in both groups. Also, we found a statistically significant direct correlation between CH and GCC thickness. Further statistical analysis revealed that both pRNFL thickness and GCC thickness are significantly influenced by CH value in a precise manner. Conclusions The first cell type affected in glaucoma is the retinal ganglion cell. We found a positive correlation between GCC thickness and CH, suggesting that CH might be a parameter to consider in the evaluation of all glaucoma patients from their first examination. Moreover, both pRNFL thickness and GCC thickness are influenced by CH, suggesting the utility of monitoring the value of CH at every checkup to detect its decrease in glaucoma patients.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

The Relationship Between Corneal Hysteresis and Retinal Ganglion Cells – A Step Forward in Early Glaucoma Diagnosis

et al. 2020

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“…Аналогичные взаимосвязи CRF и параметров экскавации были продемонстрированы в исследовании M. Hocaoğlu c соавт. [29]…”

Section: Discussionunclassified

Relationship between corneal biomechanical indexes and optic disc morphometric indexes in patients with primary open angle glaucoma

Berdnikova

Тур

Kozhevnikova³

2023

jour

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Introduction. Glaucoma is a socially significant disease. With the advent of new technologies it has become possible to diagnose this disease at an earlier stage. The aim of the investigation was to reveal the relationships between biomechanical parameters of the optic nerve disc (OND) in patients with primary open-angle glaucoma (POAG) against the background of achieving the "target" intraocular pressure (IOP). Material and methods. A retrospective cohort study was conducted in which 51 patients with POAG were included. All patients underwent a standard ophthalmologic examination. Central corneal thickness and biomechanical parameters of the cornea were also evaluated. Optical coherence tomography (OCT) was performed to assess the state of the OND. Results and discussion. Goldman IOP levels had no differences depending on glaucoma stage, but corneal compensated IOP levels differed: the lowest IOP was detected in patients with advanced glaucoma, and the highest – in patients with far advanced glaucoma. Corneal hysteresis factor (CH) and corneal resistance factor (CRF) values also depended on the glaucoma stage: the highest – in initial, the lowest – in far advanced glaucoma. The coefficient of biomechanical tension of the fibrous membrane of the eye was the highest in the group of patients with advanced glaucoma. When assessing the correlation between corneal biomechanical properties and OND parameters, there was a positive correlation of CTR with the mean thickness of RNFL, RNFL thickness in the upper segment and neuroretinal band area (NRB), and a negative – with horizontal, vertical size and excavation area. Conclusion. This investigation demonstrated the correlation between corneal parameters (CCT, CH, CRF) and their derivatives: CH/CRF ratio, corneal biomechanical tension coefficient and corneal biomechanical coefficient characterizing IOP compensation degree and morphological parameters of the optic disk in POAG against the background of "target" IOP. Protective properties of a thicker cornea, higher indices of corneal hysteresis and corneal resistance factor to glaucoma progression were shown. Keywords: glaucoma, corneal hysteresis, opti

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“…Moreover, glaucoma with normal intraocular pressure was also studied. Chen et al [ 18 ] concluded that the optic nerve strain caused by axial extension is closely related to the unilateral normal-tension glaucoma pathological mechanism, similar to the cornea and sclera biomechanics. In patients with thin central cornea thickness, the correlation between central cornea thickness the strain rate of the optic nerve, and the strain rate of orbital fat were statistically significant [ 19 ].…”

Section: Biomechanical Analysis Of Ocular Diseasesmentioning

confidence: 99%

Biomechanical analysis of ocular diseases and its in vitro study methods

Zhao

Yan

et al. 2022

BioMed Eng OnLine

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Ocular diseases are closely related to the physiological changes in the eye sphere and its contents. Using biomechanical methods to explore the relationship between the structure and function of ocular tissue is beneficial to reveal the pathological processes. Studying the pathogenesis of various ocular diseases will be helpful for the diagnosis and treatment of ocular diseases. We provide a critical review of recent biomechanical analysis of ocular diseases including glaucoma, high myopia, and diabetes. And try to summarize the research about the biomechanical changes in ocular tissues (e.g., optic nerve head, sclera, cornea, etc.) associated with those diseases. The methods of ocular biomechanics research in vitro in recent years are also reviewed, including the measurement of biomechanics by ophthalmic equipment, finite element modeling, and biomechanical analysis methods. And the preparation and application of microfluidic eye chips that emerged in recent years were summarized. It provides new inspiration and opportunity for the pathogenesis of eye diseases and personalized and precise treatment.

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Relationships between corneal biomechanics and the structural and functional parameters of glaucoma damage

Cited by 7 publications

References 0 publications

The Relationship Between Corneal Hysteresis and Retinal Ganglion Cells – A Step Forward in Early Glaucoma Diagnosis

The Relationship Between Corneal Hysteresis and Retinal Ganglion Cells – A Step Forward in Early Glaucoma Diagnosis

Relationship between corneal biomechanical indexes and optic disc morphometric indexes in patients with primary open angle glaucoma

Biomechanical analysis of ocular diseases and its in vitro study methods

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