A case of recurrent keratitis caused by Paecilomyces lilacinus and treated by
            voriconazole

Gracitelli, Carolina P. B.; Ferrar, Pedro Vanalle; Pereira, Carlos Alberto Pires; Hirai, Flávio E.; Freitas, Denise de

doi:10.5935/0004-2749.20190031

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…Other issues regarding clinically unrecognized factors might include amphotericin B-resistance of P. lilacinum , similar to that of azoles such as fluconazole or itraconazole. Many authors have suggested that even appropriate fungal drugs might not provide the desired therapeutic benefits in a short period of time, resulting in their early exclusion or treatment changes [ 50 , 51 , 52 , 53 , 54 ]. Such phenomena might also be attributed to previous steroid therapy.…”

Section: Discussionmentioning

confidence: 99%

First Report of a Case of Ocular Infection Caused by Purpureocillium lilacinum in Poland

et al. 2021

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This report describes the first case of an ocular infection induced by Purpureocillium lilacinum in Poland. The patient was a 51-year-old immunocompetent contact lens user who suffered from subacute keratitis and progressive granulomatous uveitis. He underwent penetrating keratoplasty for corneal perforation, followed by cataract surgery due to rapid uveitic cataract. A few weeks later, intraocular lens removal and pars plana vitrectomy were necessary due to endophthalmitis. The patient was treated with topical, systemic, and intravitreal voriconazole with improvement; however, the visual outcome was poor. The pathogen was identified by MALDI-TOF MS.

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Section: Discussionmentioning

confidence: 99%

First Report of a Case of Ocular Infection Caused by Purpureocillium lilacinum in Poland

et al. 2021

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“…Voriconazole has been reported to be effective in the treatment of fungal keratitis caused by different species and in cases not responding to other antifungal like natamycin and amphotericin [79][80][81][82][83][84][85]. Voriconazole has good intraocular penetration following oral administration.…”

Section: Voriconazolementioning

confidence: 99%

Fungal Keratitis: Recent Advances in Diagnosis and Treatment

Suman¹,

Kumar²,

Saxena³

et al. 2021

Infectious Eye Diseases - Recent Advances in Diagnosis and Treatment

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Fungal keratitis or fungal corneal ulcer is potentially blinding infection of cornea, is considered one of the major cause of ocular morbidity, particularly in developing countries. It is a common cause of infectious keratitis, especially in tropical and subtropical countries. Fungal keratitis is notoriously challenging to diagnosis and difficult to treat. Delay in diagnosis may result in irreversible sequelae of corneal fungal infections, which can be preventable. Fungal keratitis often have worse treatment outcomes than bacterial keratitis, Delayed diagnosis and scarcity of effective antifungal agents are the major factors for poor outcome. In the recent years considerable advancement in the diagnosis and treatment has been occurred. In this chapter, we will discuss the recent advances in diagnosis and management of fungal keratitis with a brief discussion on pathogenesis and future therapeutic models.

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A case of recurrent keratitis caused by Paecilomyces lilacinus and treated by voriconazole

Cited by 6 publications

References 9 publications

First Report of a Case of Ocular Infection Caused by Purpureocillium lilacinum in Poland

First Report of a Case of Ocular Infection Caused by Purpureocillium lilacinum in Poland

Fungal Keratitis: Recent Advances in Diagnosis and Treatment

Dexamethasone/prednisolone

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