Evaluation of choroidal perfusion changes in obese patients: ocular
                        effects of insulin resistance

Öner, Ramazan İlyas; Karadağ, Ayşe Sevgi

doi:10.5935/0004-2749.20180088

Cited by 11 publications

(16 citation statements)

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“…Of the 19 included studies in this meta-analysis, 5 measured macular thickness [ 9 , 20 , 26 – 28 ], 3 measured GC-IPL layer thickness [ 10 , 29 , 30 ], 5 measured RNFL thickness [ 12 , 27 , 28 , 31 , 32 ], and 7 studies measured peripapillary RNFL thickness [ 10 , 11 , 13 , 25 , 26 , 29 , 30 ], 5 measured cup to disc ratio [ 26 – 28 , 30 , 31 ], and 12 measured choroidal thickness [ 9 , 14 , 20 , 25 – 28 , 32 – 36 ]. All the studies reported their data as mean (SD), except one that reported some of the measurements in median (min-max) [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies matched the obesity and control groups in terms of age [ 9 , 11 , 27 – 30 , 32 , 34 , 35 ], and 8 others matched their sex [ 9 , 27 – 30 , 32 , 34 , 35 ]. Nine studies analyzed a single eye of the subjects [ 9 , 14 , 20 , 28 – 30 , 32 – 34 ], 6 investigated both eyes [ 10 , 12 , 13 , 25 , 26 , 35 ], 2 studies used a mixed approach (both single eyes and both eyes) [ 11 , 31 ], and 2 others did not state it clearly [ 27 , 36 ]. Nine utilized Zeiss Cirrus HD [ 9 , 10 , 13 , 26 – 31 ], 8 studies used Heidelberg spectralis [ 11 , 12 , 20 , 32 – 36 ], and 2 other studies benefited from other OCT models, including Topcon 3D-OCT [ 25 ] and Nidek RS-3000 [ 14 ], each in one study.…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies analyzed a single eye of the subjects [ 9 , 14 , 20 , 28 – 30 , 32 – 34 ], 6 investigated both eyes [ 10 , 12 , 13 , 25 , 26 , 35 ], 2 studies used a mixed approach (both single eyes and both eyes) [ 11 , 31 ], and 2 others did not state it clearly [ 27 , 36 ]. Nine utilized Zeiss Cirrus HD [ 9 , 10 , 13 , 26 – 31 ], 8 studies used Heidelberg spectralis [ 11 , 12 , 20 , 32 – 36 ], and 2 other studies benefited from other OCT models, including Topcon 3D-OCT [ 25 ] and Nidek RS-3000 [ 14 ], each in one study. 16 studies were from Turkey, and the remaining 3 originated from Portugal, Spain, and Thailand.…”

Section: Resultsmentioning

confidence: 99%

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Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis

2022

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Background Previous studies proposed possible applications of spectral-domain optical coherence tomography (SD-OCT) measurements in prognosticating pathologies observed in overweight/obesity, including ocular, vascular, and neurologic consequences. Therefore, we conducted a systematic review and meta-analysis to investigate the changes in the in SD-OCT measurements of the patients with higher body mass index (BMI) compared to normal weight individuals. Materials and methods We conducted a systematic search on PubMed, Scopus, and Embase. The search results underwent two-phase title/abstract and full-text screenings. We then analyzed SD-OCT measurements differences in patients with high BMI and controls, and performed meta-regression, sub-group analysis, quality assessment, and publication bias assessment. The measurements included macular thickness, cup to disc ratio, ganglion cell-inner plexiform layer (GC-IPL) and its sub-sectors, RNFL and peripapillary RNFL (pRNFL) and their sub-layers, and choroidal thickness and its sub-sectors. Results 19 studies were included in this meta-analysis accounting for 1813 individuals, 989 cases and 824 controls. There was an overall trend towards decreased thickness in high BMI patients, but only two measurements reached statistical significance: temporal retinal nerve fiber layer (RNFL) (Standardized mean difference (SMD): -0.33, 95% confidence interval (CI): -0.53 to -0.14, p<0.01) and the choroidal region 1.0 mm nasal to fovea (SMD: -0.38, 95% CI: -0.60 to -0.16, p<0.01). Conclusion Some ocular layers are thinner in patients with higher BMI than the controls. These SD-OCT measurements might correlate with adverse events related to increased body weight and have prognostic abilities. As SD-OCT is a robust, rapid and non-invasive tool, future guidelines and studies are needed to evaluate the possibility of their integration into care of the patients with obesity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis

2022

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“…30,31 A higher BMI was also associated with a reduction in CT in some of the locations, and this relation was previously reported. 32,33 In the multivariable regression analysis for the SLE group alone, in addition to age and axial length, anticoagulants presented a negative association with CT in some locations. This association may represent a subset of SLE patients in whom the ischemic and atrophic process of the choroidal vasculature is more advanced.…”

Section: Discussionmentioning

confidence: 94%

<p>Choroidal thickness changes in systemic lupus erythematosus patients</p>

Dias‐Santos

Ferreira

Pinheiro

et al. 2019

OPTH

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Purpose: To compare choroidal thickness (CT) between patients with systemic lupus erythematosus (SLE) without ophthalmologic manifestations and a control group. To study the effects in CT of disease duration, activity index, medication and systemic comorbidities. Methods: Cross-sectional study where spectral-domain optical coherence tomography with enhanced depth imaging was used to measure CT in 13 locations, subfoveally and at 500-µm intervals along a horizontal and a vertical section from the fovea. Linear regression models were used. Results: Sixty-eight SLE patients and fifty healthy controls were enrolled. CT multivariable analysis revealed lower values in SLE patients (12.93-26.73 µm thinner) in all locations, except the inferior quadrants (6.48-10.44 µm thicker); however, none of these results reached statistical significance. Contrary to the control group, the normal topographic variation in CT between macular quadrants and from the center to the periphery was not observed in the SLE group. Multivariable analysis in the SLE group alone revealed a significant negative association with anticoagulants (50.10-56.09 µm thinner) and lupus nephritis (40.79-58.63 µm thinner). Contrary to controls, the CT of SLE patients did not respond to changes in mean arterial pressure. Conclusion: CT in SLE appears to be thinner, particularly in the subset of patients with nephritis and taking anticoagulants, suggesting more advanced systemic vascular disease. Choroidal responses to hemodynamic changes may also be altered in SLE.

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“…However, other studies have found the opposite, reporting increased choroidal thickness in obese children compared to controls (using a similar imaging approach) (Bulus et al 2017). Significantly thinner choroidal thickness was also reported in morbidly obese adults compared to nonobese controls (Dogan et al 2016;Oner and Karadag 2018).…”

Section: Metabolic Risk Factorsmentioning

confidence: 96%

Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions

et al. 2019

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Aging of the microcirculatory network plays a central role in the pathogenesis of a wide range of agerelated diseases, from heart failure to Alzheimer's disease. In the eye, changes in the choroid and choroidal microcirculation (choriocapillaris) also occur with age, and these changes can play a critical role in the pathogenesis of age-related macular degeneration (AMD). In order to develop novel treatments for amelioration of choriocapillaris aging and prevention of AMD, it is essential to understand the cellular and functional changes that occur in the choroid and choriocapillaris during aging. In this review, recent advances in in vivo analysis of choroidal structure and function in AMD patients and patients at risk for AMD are discussed. The pathophysiological roles of fundamental cellular and molecular mechanisms of aging including oxidative GeroScience

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Evaluation of choroidal perfusion changes in obese patients: ocular effects of insulin resistance

Cited by 11 publications

References 0 publications

Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis

Spectral-domain OCT measurements in obesity: A systematic review and meta-analysis

<p>Choroidal thickness changes in systemic lupus erythematosus patients</p>

Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions

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