Ocular manifestations of psoriasis

Cruz, Natasha Ferreira Santos da; Brandão, Larissa Silva; Cruz, Sérgio Ferreira Santos da; Cruz, Sergio A.; Pires, Carla Andréa Avelar; Carneiro, Francisca Regina Oliveira

doi:10.5935/0004-2749.20180044

Cited by 27 publications

(20 citation statements)

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“…The most common clinical ocular change associated with psoriasis is keratoconjunctivitis sicca (dry eye syndrome), which is present in 18.75% of patients, and blepharitis (2,12,13). Other changes include conjunctivitis, uveitis, punctate keratitis, pinguecula, cataracts, glaucoma, corneal abscesses, pterygium, or abnormalities of retinal vascularization (5,14).…”

Section: Ophthalmological Changesmentioning

confidence: 99%

“…Several studies on patients with psoriasis have demonstrated an association between Psoriasis Area and Severity Index (PASI) scores and the presence of ocular manifestations. Patients with blepharitis tend to have low PASI scores, whilst patients with keratitis have moderate-to-severe PASI scores (2,14). Paradoxically, a study performed in 2013 on 100 patients with psoriasis concluded that there is no significant association between severe cases of psoriasis and eye lesions; therefore, all patients should be evaluated ophthalmologically to establish an accurate diagnosis (12).…”

Section: Ophthalmological Changesmentioning

confidence: 99%

“…Dry eye syndrome occurs in patients with psoriasis due to an obstructive dysfunction of the excretory ducts of the meibomian glands. Although their secretory function is normal, the dysfunction results from epithelial keratinization of the glandular ducts (1,2). The patients experience a feeling of dry eyes, foreign body sensation, blurry vision and photophobia, with symptoms worsening throughout the day (6).…”

Section: Ophthalmological Changesmentioning

confidence: 99%

“…Psoriasis affects 1-3% of the adult population, has a negative impact on the quality of life of the patients (1), and it is no longer considered as a disease exclusively affecting the skin, as it is associated with several systemic complications, including cardiovascular, metabolic, cerebrovascular, articular, hepatic, autoimmune and ocular damage. Currently, ophthalmological manifestations have an occurrence rate of 10-12% among patients with psoriasis (2,3). However, these figures do not reflect the true magnitude of how significantly this organ is affected.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Psoriasis beyond the skin: Ophthalmological changes (Review)

et al. 2021

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Psoriasis is a chronic, immune-mediated inflammatory disease of unknown etiology that may be associated with abnormal T-lymphocyte function. Ocular manifestations associated with psoriasis, particularly artropathic or pustular psoriasis, usually affect men, often during exacerbations of the disease. It has been reported that eye damage tends to occur later compared with cutaneous or joint manifestations, blindness being the most disabling complication. Previous studies have focused on ophthalmic manifestations and identified several etiopathogenic mechanisms. Psoriasis may be associated with eye complications such as lesions of the eyelids, conjunctiva and others, with systemic inflammation being the main contributor. In addition, the treatment used for psoriasis may cause ocular changes. The main ophthalmic manifestations associated with psoriasis are keratoconjunctivitis sicca, blepharitis, conjunctivitis and uveitis. The treatment of uveitis, perceived as one of the most serious eye conditions, is controversial and has yet to be clearly determined. Thus, the aim of the present review was to emphasize the importance of regular eye examination for patients with psoriasis, either those receiving biological treatment or those not receiving treatment, in order to diagnose and manage the disease appropriately.

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Section: Ophthalmological Changesmentioning

confidence: 99%

Section: Ophthalmological Changesmentioning

confidence: 99%

Section: Ophthalmological Changesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Psoriasis beyond the skin: Ophthalmological changes (Review)

et al. 2021

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“…As in most systemic, inflammatory, chronic diseases, ocular manifestations can occur (35). The incidence of ocular involvement in psoriasis largely varies in the literature between 12 and 58% (36,37) and even up to 81.4% in more recent studies (38). The eyelid manifestations include blepharitis, which is the most frequent one, together with erythema, psoriatic plaques, and edema leading to eyelid abnormalities such as ectropion, trichiasis, and madarosis.…”

Section: Comorbiditiesmentioning

confidence: 99%

Management of psoriasis in children (Review)

et al. 2021

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Psoriasis is a common long-lasting, inflammatory disease that mainly affects the skin. The incidence of this condition has increased significantly over time and at this point, it affects approximately 1% of children. Psoriasis can appear at any age, including childhood and adolescence, with a higher frequency in girls, an earlier onset being associated with severe psoriasis. The pathology is the result of the interaction between genetics and trigger factors such as infections, stress, diet, obesity, and chemical irritants. Paradoxically, tumor necrosis factor (TNF)-α inhibitors (infliximab, adalimumab) may induce psoriasis in children. Psoriasis is a long-term condition with periods of exacerbation; thus, the quality of life can be affected and patients should receive psychosocial support. Although most children have mild disease and topical treatment is efficient, some cases are challenging to treat. The aim of this review was to provide an overview of the current knowledge concerning the epidemiology, etiology, pathogenesis, clinical features, comorbidities, and treatment of psoriasis in children and also to emphasize the need for a multidisciplinary approach to this complex pathology.

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Ocular manifestations of psoriasis: An inflammatory disease beyond the skin

Aryanian

Shirzadian

Hatami

et al. 2022

J of Gen and Family Med

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Background Psoriasis is a chronic inflammatory disorder, mainly involves skin. Aims To evaluate the prevalence of ocular manifestations in Iranian patients with psoriasis, compared to healthy controls. Materials and methods Forty psoriasis patients and 40 age‐ and gender‐matched healthy controls were enrolled in the study and underwent a comprehensive ophthalmologic assessment. Results Only meibomian gland dysfunction was significantly more common among patients with psoriasis, compared to control group ( p value: 0.011). Regarding intraocular pressure (IOP), the mean values for both patients and healthy controls were within the normal range and mean IOP in patients was even lower than normal controls, although this difference was significant only for left eye ( p value: 0.049). A strong positive correlation between PASI and tear meniscus height for both right and left eyes ( p value: 0.005, r : 0.44 for OD and p value: 0.003, r : 0.46 for OS.) was noted. Meibomian gland dysfunction was also positively correlated with disease duration for right and left palpebras ( p : 0.04, r : 0.31 for both). Conclusion Psoriasis can lead to meibomian gland dysfunction, especially in patients with long‐lasting disease. Hence, dermatologists and general practitioners should be vigilant in this regard when visiting psoriasis patients, especially those who have higher PASI values or long‐lasting disease.

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Ocular manifestations of psoriasis

Abstract: Patients with psoriasis should undergo regular eye exams, regardless of risk factors, to monitor for the progression of symptomatic or asymptomatic ocular manifestations.

Cited by 27 publications

References 0 publications

Psoriasis beyond the skin: Ophthalmological changes (Review)

Psoriasis beyond the skin: Ophthalmological changes (Review)

Management of psoriasis in children (Review)

Ocular manifestations of psoriasis: An inflammatory disease beyond the skin

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