Undifferentiated pleomorphic sarcoma of the orbital region: a case report

Abstract

Undifferentiated pleomorphic sarcoma (UPS) is an extremely rare tumor that occurs in the head and neck region. Here, we report a unique case of a primary undifferentiated pleomorphic sarcoma in the orbital region. A 35-year-old woman presented with a progressive proptosis and periocular edema for 1 year. She had no previous history of surgery, skin malignancy, or radiation. Imaging tests showed an extraconal mass, not involving the muscles. The tumor was surgically removed and adjuvant radiotherapy was required after histological examination, which showed an undifferentiated pleomorphic sarcoma of the orbit. There was no recurrence after 1 year of follow-up. Though rare, undifferentiated pleomorphic sarcoma should be included in the differential diagnoses of orbital tumors.

Undifferentiated pleomorphic sarcoma of the lateral thigh with KRAS/NF1 co-mutation recurred after repetitive surgical resection: A case report and review of the literature

“…However, the relationship between tumor depth and mortality was insignificant. In reviewing relevant case reports and recent studies, we found that the prognosis and survival of UPS patients with deep tissue were different, which may also be related to the low sample size (11)(12)(13)(14)(15)(16).…”

“…(1) We noted that in some case reports, the excision of the tumor and area of tumor margins were not described in great detail (13)(14)(15). In such patients, more attention should be paid to the depth and size of tumor invasion during surgery, especially during surgical resection, more adequate tissue exposure and expanded resection are necessary, and we need to explore deeper tissue to find tumor tissue that might have been overlooked.…”

Giant pleomorphic sarcoma of the tongue base – a cured clinical case report and literature review

“…UPS histopathology includes marked nuclear pleomorphism, intense mitotic activity, and areas of necrosis. Although the histogenesis of this type of neoplasm remains debated, it is most commonly viewed as a primitive pleomorphic sarcoma with partial fibroblastic and histiocytic differentiation, reflected by the production of collagen and intratumorally phagocytosis [ 15 ].…”