Corneal endothelial cell density and pterygium: a cross-sectional study

Sousa, Hugo Coelho Carvalho; Silva, Ludmila Nascimento Pinto; Tzelikis, Patrick Frensel

doi:10.5935/0004-2749.20170077

Cited by 11 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 Theoretically, these mediators and UV light may also damage deeper corneal endothelial cells (ECC) and thus corneal endothelial cell density (ECD) may be decreased in eyes with pterygium. 10 Although results from previous clinical studies were consistent with this theory, [11][12][13] we found that ECD was not significantly decreased in eyes seen in our clinics with primary pterygium. We thus speculated that the development of pterygium might not be associated with ECD decrease.…”

Section: -4supporting

confidence: 76%

Primary pterygium is not associated with corneal endothelial cell decrease in a rural Chinese population

Atik

et al. 2019

Preprint

View full text Add to dashboard Cite

Purpose: To investigate corneal endothelial cell density (ECD) in eyes with primary pterygium. Methods: We first conducted a retrospective study to compare the ECD between 1670 eyes with primary pterygium and 4060 eyes without pterygium. Then we designed a prospective study to confirm the findings of our retrospective study in 95 patients with unilateral primary pterygium. Results: In the retrospective study, the mean ECD in eyes with primary pterygium (2453±306 cells/mm2) was significantly lower than those in eyes without pterygium (2529±313 cells/mm2, P<0.0001). However, the difference was not as high as previously reported (76 cells/mm2, 3.1%). In the prospective study, there was no significant difference in mean ECD in eyes with unilateral primary pterygium (2480±263 cells/mm2) and the contralateral eyes with no pterygium (2527±277 cells/mm2, P=0.20). There was also no significant difference in hexagonality (P=0.10) or coefficient of variation of size (P=0.15) of corneal endothelial cells between eyes with pterygium and the contralateral eyes with no pterygium. Conclusion: Primary pterygium may not be associated with a decrease in ECD in our study population of rural Chinese patients.

show abstract

Section: -4supporting

confidence: 76%

Primary pterygium is not associated with corneal endothelial cell decrease in a rural Chinese population

Atik

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…9 Theoretically, these mediators and ultraviolet light may also damage deeper corneal endothelial cells (ECC) and thus corneal endothelial cell density (ECD) may be decreased in eyes with pterygium. 10 Although results from previous clinical studies were consistent with this theory, [11][12][13] it was noticed that ECD was not significantly decreased in eyes seen in our clinics with primary pterygium. Thus, an investigation was conducted to determine whether the development of pterygium was associated with ECD decrease in the local population.…”

supporting

confidence: 74%

“…5,6,19 Studies have also shown that pterygium may be associated with changes in deeper corneal layers. [11][12][13] Mootha et al first described changes in the corneal endothelium and Descemet membrane underlying or directly adjacent to pterygium. 13 In their study the mean ECD decrease was 367 cells/ mm 2 in eyes with unilateral pterygium.…”

Section: Discussionmentioning

confidence: 99%

“…Pterygium has been found to have a significant impact on the corneal surface, reducing the spherical power and surface regularity index while increasing astigmatism and the surface asymmetry index 2000. Studies have also shown that pterygium may be associated with changes in deeper corneal layers 2004. Mootha et al first described changes in the corneal endothelium and Descemet membrane underlying or directly adjacent to pterygium 2004.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The association between primary pterygium and corneal endothelial cell density

Atik

et al. 2020

Clinical and Experimental Optometry

View full text Add to dashboard Cite

Background: To investigate corneal endothelial cell density in eyes with primary pterygium. Methods: A retrospective study was conducted to compare endothelial cell density between 1,565 patients with primary pterygium and 3,448 patients without pterygium. Then a prospective study was designed to confirm the findings of the retrospective study in 95 patients with unilateral primary pterygium. Results: In the retrospective study, the mean endothelial cell density in eyes with primary pterygium was significantly lower (2,454 AE 303 cells/mm 2) than those in eyes without pterygium (2,525 AE 312 cells/mm 2 , p < 0.0001). However, the difference was not as high as previously reported (71 cells/mm 2 , 2.9 per cent). In the prospective study, there was no significant difference in mean endothelial cell density in eyes with unilateral primary pterygium (2,480 AE 263 cells/mm 2) and the contralateral eyes with no pterygium (2,527 AE 277 cells/mm 2 , p = 0.20). There was also no significant difference in hexagonality (p = 0.10) or coefficient of variation of size (p = 0.15) of corneal endothelial cells between eyes with pterygium and the contralateral eyes with no pterygium. Conclusion: Primary pterygium may not be associated with a decrease in endothelial cell density in our study population of rural Chinese patients.

show abstract

“…Yang et al [15] suggested that pterygium cells invading the anterior elastic layer could activate the expression of matrix metalloproteinases such as MMP-1, MMP-2, and MMP-9, thus affecting the connection of hemidesmosomes, which may lead to damage to corneal endothelial cells. In regard to corneal endothelial cells in pterygium, some studies noted [16][17][18][19] that the ECD was lower in the central or peripheral cornea of eyes with pterygium than in that of control eyes, whereas other studies [10] did not find any difference between eyes with pterygium and healthy eyes. Different results may be caused by different observation points.…”

Section: Discussionmentioning

confidence: 96%

In Vivo Confocal Microscopy Observation of Cell and Nerve Density in Different Corneal Regions with Monocular Pterygium

Shen

Sun

2020

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose. To investigate the effects of pterygium on corneal cell and nerve density in patients with unilateral pterygium using in vivo laser scanning confocal microscopy (LSCM). Methods. In this cross-sectional study, 24 patients with unilateral pterygium who were treated in the Department of Ophthalmology of the Second People’s Hospital of Wuxi City from April 2018 to July 2018 were analyzed. Each eye with pterygium and its fellow eye were imaged by LSCM. The density of basal corneal epithelial cells, anterior stromal cells, posterior stromal cells, dendritic cells, and endothelial cells in pterygium and adjacent clear cornea was measured. In the fellow eyes, the central cornea, nasal cornea, nasal mid-peripheral cornea, and temporal cornea were imaged. The difference in the density of cells and subepithelial nerve fibers in different corneal regions of eyes with pterygium was analyzed. The cell and nerve density of the fellow cornea were also measured to exclude the influencing factors. Results. The density of corneal basal epithelial cells in the central corneas of eyes with pterygium was 6497 ± 1776 cells/mm2, which was higher than that in the area near the head of pterygium (5580 ± 1294 cells/mm2, P<0.001), the region above pterygium (6097 ± 1281 cells/mm2, P=0.049), and the region below pterygium (5463 ± 1007 cells/mm2, P=0.001). The density of anterior stromal cells in the central cornea was 742 ± 243 cells/mm2, which was higher than that in the area near the head of pterygium (587 ± 189 cells/mm2, P=0.005), the region below pterygium (492 ± 159 cells/mm2, P=0.005), and the temporal cornea (574 ± 164 cells/mm2, P=0.003). The density of endothelial cells in the central cornea was 2398 ± 260 cells/mm2, which was higher than that in the area near the head of pterygium (2296 ± 231 cells/mm2, P=0.011) and the region below pterygium (2272 ± 400 cells/mm2, P=0.020). The density of dendritic cells in the central cornea was 53 ± 48 cells/mm2, which was lower than that in the area near the head of pterygium (250 ± 224 cells/mm2, P=0.001), the upper region (103 ± 47 cells/mm2, P=0.006), and the lower region (90 ± 48 cells/mm2, P=0.023). The corneal nerve fiber length (CNFL) in the center was higher than that in the area near the head of pterygium, the upper region, and the lower region. Compared with fellow eyes, eyes with pterygium had a significantly higher mean corneal power (KM) (P<0.001). There was a significant positive linear relationship between the corneal area invaded by pterygium of pterygia and KM (r = 0.609, P=0.009). Conclusion. Basal epithelial cells, stromal cells, endothelial cells, dendritic cells, and subepithelial nerve fibers in the central cornea of eyes with pterygium were different from those of pterygium and adjacent clear cornea. LSCM is effective for observing the morphology and quantity of corneal cells in pterygium.

show abstract

Corneal endothelial cell density and pterygium: a cross-sectional study

Abstract: Compared with the contralateral eyes, those of patients with unilateral pterygium were associated with a decrease in corneal endothelial cell density.

Cited by 11 publications

References 0 publications

Primary pterygium is not associated with corneal endothelial cell decrease in a rural Chinese population

Primary pterygium is not associated with corneal endothelial cell decrease in a rural Chinese population

The association between primary pterygium and corneal endothelial cell density

In Vivo Confocal Microscopy Observation of Cell and Nerve Density in Different Corneal Regions with Monocular Pterygium

Contact Info

Product

Resources

About