Optical coherence tomography angiography artifactual choroidal neovascularization
            in optic disc pit maculopathy

Roizenblatt, Marina; Müller, Léo; Lobos, Claudio Zett; Saraiva, V.S.; Magalhães, Octaviano; Maia, André

doi:10.5935/0004-2749.20170062

Cited by 3 publications

(1 citation statement)

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“…Optical coherence tomography angiography should be used in further studies of ODP and other optic nerve anomalies to improve the understanding of the anatomical and functional impacts of these diseases. Other reports have shown the utility of using OCTA to monitor optic nerve capillary dropout 17 and evaluate for the presence of choroidal neovascularization 18 in ODP eyes. Additional research evaluating the impact of peripapillary vascular dropout on nerve fiber layer structure and visual field function would be beneficial in elucidating the pathophysiology of ODP.…”

Section: Discussionmentioning

confidence: 99%

Vascular Perfusion Density Mapping Using Optical Coherence Tomography Angiography Comparing Normal and Optic Disk Pit Eyes

Jiang

Turco

Choudhry

2019

RETINAL Cases &Amp; Brief Reports

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Purpose: Optic disk pits (ODPs) are typically detected incidentally as small, gray, unilateral, oval-shaped excavation in the temporal optic disk on routine fundus examination. In this cross-sectional retrospective case series, we report optical coherence tomography angiography findings in patients with unilateral ODPs and describe changes in vessel perfusion associated with ODP.Methods: A total of eight eyes (four with ODP and four normal contralateral) were included in this study. Patients were excluded if any other optic disk abnormalities were present. Spectral-domain optical coherence tomography angiography (AngioVue; Optovue, Fremont, CA) imaging was conducted to map the vascularization of three layers in the optic nerve over a 4.5-mm • 4.5-mm region. The radial peripapillary capillaries, the nerve head capillaries, and the choriocapillaris were automatically segmented based on the OCT system software, and the capillary perfusion density (CPD) was quantified for each layer. Kruskal-Wallis one-way analysis of variance was used to compare CPD in normal and ODP eyes of four patients with monocular ODP.Results: Overall, CPD was lower in eyes with ODP compared with the contralateral normal eye in the radial peripapillary capillary (0.4521 ± 0.08 vs. 0.5505 ± 0.03, P = 0.08) and nerve head capillary layers (0.5461 ± 0.08 vs. 0.5989 ± 0.01, P = 0.08). Significantly lower CPD values were associated with ODP eyes in the radial peripapillary capillary layer within the disk (P = 0.04), inferior nasal (P = 0.04), and temporal (P = 0.02) regions and in the nerve head vessel layer within the disk region (P = 0.04). Significantly higher CPD values were associated with ODP eyes in the choriocapillaris layer within the nasal (P = 0.02), superior temporal (P = 0.02), and inferior temporal (P = 0.02) regions. Visual acuity was also decreased in ODP eyes at 0.4 ± 0.3 logarithm of the minimum angle of resolution units (20/50) compared with normal eyes at 0.1 ± 0.1 logarithm of the minimum angle of resolution units (20/25) (P = 0.12).Conclusion: This study demonstrated that the presence of an ODP is associated with decreased vascular density in some regions of the optic disk and reduced visual acuity.

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Section: Discussionmentioning

confidence: 99%

Vascular Perfusion Density Mapping Using Optical Coherence Tomography Angiography Comparing Normal and Optic Disk Pit Eyes

Jiang

Turco

Choudhry

2019

RETINAL Cases &Amp; Brief Reports

View full text Add to dashboard Cite

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Central visual field defects and optical coherence tomography angiography changes following congenital optic disc pit without maculopathy

Venkatesh

Sharief

Arora

et al. 2022

Clinical and Experimental Optometry

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Changes in Outcomes of Macular Optical Coherence Tomography Angiography Following Surgery for Optic Disc Pit Maculopathy

Akıdan,

Erol,

Gedik

et al. 2024

Diagnostics

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Purpose: we aimed to report on the optical coherence tomography angiography (OCTA) outcomes of eight patients with optic disc pit maculopathy (ODP-M) who were treated with 23-gauge pars plana vitrectomy (PPV). Methods: We examined sixteen eyes of eight patients—eight eyes with ODP-M and eight healthy fellow eyes. Fundus color photography, fundus autofluorescence, fundus fluorescein angiography, optical coherence tomography (OCT), and OCTA were performed. The vascular density, choriocapillaris blood flow (CCBF), and foveal avascular zone (FAZ) were analyzed using OCTA. Moreover, the correlation between the best-corrected visual acuity (BCVA) and macular OCTA parameters was assessed. Results: Compared with the healthy fellow eyes, the eyes with ODP-M preoperatively were found to have decreased BCVA, superficial capillary plexus (SCP) vascular density (i.e., total, foveal, parafoveal, and perifoveal), deep capillary plexus (DCP) vascular density (i.e., total, parafoveal, and perifoveal), and CCBF but a significantly increased FAZ (p < 0.05). When the eyes with ODP-M were analyzed pre- and postoperatively at month 12 after surgery, the BCVA, SCP vascular density (i.e., perifoveal), and CCBF had significantly increased, and the FAZ had significantly decreased (p < 0.05). When the eyes with ODP-M were compared with the healthy fellow eyes postoperatively at month 12, the BCVA, SCP, and DCP vascular density parameters had increased, along with CCBF, and the FAZ had decreased in eyes with ODP-M, though not to the levels of the healthy fellow eyes (p < 0.05). Moreover, a positive correlation was found between the postoperative BCVA and SCP total vascular density (p < 0.05). Conclusion: The BCVA and macular OCTA parameters improved in eyes with ODP-M at month 12 following surgery. However, the BCVA and OCTA of the eyes operated on did not reach the levels of the healthy fellow eyes, possibly due to impaired choroidal blood flow (CBF) recovery and the presence of a larger FAZ. In summary, OCTA seems to be useful for assessing qualitative and quantitative perioperative microvascular changes.

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Optical coherence tomography angiography artifactual choroidal neovascularization in optic disc pit maculopathy

Cited by 3 publications

References 0 publications

Vascular Perfusion Density Mapping Using Optical Coherence Tomography Angiography Comparing Normal and Optic Disk Pit Eyes

Vascular Perfusion Density Mapping Using Optical Coherence Tomography Angiography Comparing Normal and Optic Disk Pit Eyes

Central visual field defects and optical coherence tomography angiography changes following congenital optic disc pit without maculopathy

Changes in Outcomes of Macular Optical Coherence Tomography Angiography Following Surgery for Optic Disc Pit Maculopathy

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